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Respiratory Research
Published in: Respiratory Research 1/2013

Open Access 01-12-2013 | Letter to the Editor

Role of epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD)

Authors: Sukhwinder Singh Sohal, Eugene Haydn Walters

Published in: Respiratory Research | Issue 1/2013

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Abstract

Small airway fibrosis is the main contributor to physiological airway dysfunction in COPD. One potential mechanism contributing to small airway fibrosis is epithelial mesenchymal transition (EMT). When associated with angiogenesis (so called EMT-Type-3) it may well also be the link with the development of cancer, which is closely associated with COPD and predominantly in large airways. In a recent study published in Respiratory Research, Qin Wang and colleagues investigated the role of urokinase plasminogen activator receptor (uPAR) in EMT in small airway epithelium of COPD patients. However, there are some issues with the paper which we wish to comment on.
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Literature
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Metadata
Title
Role of epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD)
Authors
Sukhwinder Singh Sohal
Eugene Haydn Walters
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2013
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/1465-9921-14-120

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