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Respiratory Research
Published in: Respiratory Research 1/2011

Open Access 01-12-2011 | Review

The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer

Authors: Christian Herr, Timm Greulich, Rembert A Koczulla, Silke Meyer, Tetyana Zakharkina, Meret Branscheidt, Rebecca Eschmann, Robert Bals

Published in: Respiratory Research | Issue 1/2011

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Abstract

The role of vitamin D (VitD) in calcium and bone homeostasis is well described. In the last years, it has been recognized that in addition to this classical function, VitD modulates a variety of processes and regulatory systems including host defense, inflammation, immunity, and repair. VitD deficiency appears to be frequent in industrialized countries. Especially patients with lung diseases have often low VitD serum levels. Epidemiological data indicate that low levels of serum VitD is associated with impaired pulmonary function, increased incidence of inflammatory, infectious or neoplastic diseases. Several lung diseases, all inflammatory in nature, may be related to activities of VitD including asthma, COPD and cancer. The exact mechanisms underlying these data are unknown, however, VitD appears to impact on the function of inflammatory and structural cells, including dendritic cells, lymphocytes, monocytes, and epithelial cells. This review summarizes the knowledge on the classical and newly discovered functions of VitD, the molecular and cellular mechanism of action and the available data on the relationship between lung disease and VitD status.
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Metadata
Title
The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer
Authors
Christian Herr
Timm Greulich
Rembert A Koczulla
Silke Meyer
Tetyana Zakharkina
Meret Branscheidt
Rebecca Eschmann
Robert Bals
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2011
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/1465-9921-12-31

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