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Journal of Endocrinological Investigation

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01-05-2018 | Original Article

The effect of vitamin D supplementation in combination with low-calorie diet on anthropometric indices and androgen hormones in women with polycystic ovary syndrome: a double-blind, randomized, placebo-controlled trial

Authors: S. Jafari-Sfidvajani, R. Ahangari, M. Hozoori, H. Mozaffari-Khosravi, H. Fallahzadeh, A. Nadjarzadeh

Published in: Journal of Endocrinological Investigation | Issue 5/2018

Abstract

Purpose

Polycystic ovary syndrome (PCOS) is known as the most common endocrine disorder in reproductive age women. The aim of this studywas to evaluate the effects of vitamin D supplementation in combination with low-calorie diet on anthropometric indices, reproductive hormones and menstrual regularity in overweight and obese PCOS women.

Methods

In this randomized controlled clinical trial, 60 PCOS women with vitamin D insufficiency were randomly assigned to 12 weeks of either (1) weight-loss intervention + 50,000 IU/week oral vitamin D3 or (2) weight-loss intervention + placebo. At the beginning and end of the study, the anthropometric indices, body composition, 25-hydroxyvitamin D, total testosterone, dehydroepiandrosterone sulfate (DHEAS), sex hormone-binding globulin (SHBG) and free androgen index (FAI) were measured and regularity of menses was compared among the two groups.

Result

After 12-week intervention, median of serum 25-hydroxyvitamin D3 significantly increased from 18.5 (10.75–20) ng/ml to 42.69 (34–53.25) ng/ml in vitamin D group compared to placebo group (p < 001). Moreover, there was a significant improvement in frequency regular menstrual cycle (p = 0.01). Mean of weight, body mass index, fat mass, waist and hip circumference and waist-to-hip ratio significantly decreased in both groups, but was not different between two groups. Mean of total testosterone insignificantly decreased from 0.7 to 0.5 ng/ml in vitamin D group (p = 0.18). In addition, we did not observe significant differences regarding DHEAS, FAI and SHBG between two groups.

Conclusions

In women with PCOS, androgen profile did not change with vitamin D supplementation when combined with low-calorie diet, but menstrual frequency significantly improved.

Clinical Trial Registration Number

IRCT2016062710826N19.

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Title: The effect of vitamin D supplementation in combination with low-calorie diet on anthropometric indices and androgen hormones in women with polycystic ovary syndrome: a double-blind, randomized, placebo-controlled trial
Authors: S. Jafari-Sfidvajani
R. Ahangari
M. Hozoori
H. Mozaffari-Khosravi
H. Fallahzadeh
A. Nadjarzadeh
Publication date: 01-05-2018
Publisher: Springer International Publishing
Published in: Journal of Endocrinological Investigation / Issue 5/2018
Electronic ISSN: 1720-8386
DOI: https://doi.org/10.1007/s40618-017-0785-9

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