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Molecular Diagnosis & Therapy
Published in: Molecular Diagnosis & Therapy 6/2012

01-12-2012 | Review Article

Biomarkers of Therapeutic Response to BCL2 Antagonists in Cancer

Authors: Lloyd T. Lam, Haichao Zhang, Brenda Chyla

Published in: Molecular Diagnosis & Therapy | Issue 6/2012

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Abstract

Cancer cells persist by resisting programmed cell death or apoptosis. In particular, an imbalance of proteins that regulate apoptosis leads to lack of response to apoptotic stimuli. Thus, restoring the ability of cancer cells to undergo apoptosis is highly desirable. One apoptosis pathway, the intrinsic pathway, involves perturbation of the mitochondria. The major players of this pathway are the members of the B cell CLL/lymphoma 2 (BCL2) family. Currently, three BCL2 antagonists are in clinical trials for cancer treatment. While these antagonists show various specificity and potency, the development of companion diagnostics is crucial for developing these compounds into viable cancer treatments. In this review we describe predictive and pharmacodynamic biomarkers for these agents. Future directions on biomarker development for this class of antagonist are also discussed.
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Metadata
Title
Biomarkers of Therapeutic Response to BCL2 Antagonists in Cancer
Authors
Lloyd T. Lam
Haichao Zhang
Brenda Chyla
Publication date
01-12-2012
Publisher
Springer International Publishing AG
Published in
Molecular Diagnosis & Therapy / Issue 6/2012
Print ISSN: 1177-1062
Electronic ISSN: 1179-2000
DOI
https://doi.org/10.1007/s40291-012-0003-6

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Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

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