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01-09-2020 | Lung Cancer | Systematic Review

Occupational Physical Activity and Lung Cancer Risk: A Systematic Review and Meta-Analysis

Authors: Benny Rana, Liang Hu, Andrew Harper, Chao Cao, Cheryl Peters, Darren Brenner, Lin Yang

Published in: Sports Medicine | Issue 9/2020

Abstract

Objective

To deliver a systematic review of the literature synthesizing data on the association of occupational physical activity with lung cancer risk in observational studies.

Design

Systematic review with meta-analysis.

Data Source

A literature search was performed in the electronic databases of PubMed/Medline and Embase.

Eligibility Criteria for Selecting Studies

We screened peer-reviewed articles from prospective cohort and case–control studies assessing the association of occupational physical activity with lung cancer risk. A sex-specific meta-analysis assessed the association of high (compared to low/sedentary) level occupational physical activity with lung cancer risk, estimating the relative risk (RR) and odds ratio (OR) with a 95% confidence interval (CI).

Results

The systematic search identified 2065 articles, among which, eight journal articles met the inclusion criteria. The meta-analysis adjusted for age, smoking status and/or intensity, with a pooled sample size of 532,282 participants (men: 219,410; women: 312,872). A random-effect model of four prospective and four case–control studies indicated that men who engage in high-level occupational physical activity had a 15% higher risk (OR 1.15, 95% CI 1.04–1.28) of lung cancer than those engaging in low/sedentary-level occupational physical activity. There was no association observed among women (OR = 1.01, 95% CI 0.77–1.34) based on three available studies (prospective cohort: n = 2; case–control: n = 1).

Conclusions

Findings from the review suggest a higher risk of lung cancer among men reporting high-level occupational physical activity. Further prospective studies incorporating rigorous measures of domain-specific physical activity, detailed smoking status and intensity, and other occupational exposures are needed to elucidate this association.

PROSPERO Registration ID

CRD42019137911.

Available only for authorised users

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Title: Occupational Physical Activity and Lung Cancer Risk: A Systematic Review and Meta-Analysis
Authors: Benny Rana
Liang Hu
Andrew Harper
Chao Cao
Cheryl Peters
Darren Brenner
Lin Yang
Publication date: 01-09-2020
Publisher: Springer International Publishing
Keywords: Lung Cancer
Lung Cancer
Lung Cancer
Published in: Sports Medicine / Issue 9/2020
Print ISSN: 0112-1642
Electronic ISSN: 1179-2035
DOI: https://doi.org/10.1007/s40279-020-01312-w

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Occupational Physical Activity and Lung Cancer Risk: A Systematic Review and Meta-Analysis

Abstract

Objective

Design

Data Source

Eligibility Criteria for Selecting Studies

Results

Conclusions

PROSPERO Registration ID

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objective

Design

Data Source

Eligibility Criteria for Selecting Studies

Results

Conclusions

PROSPERO Registration ID

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