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01-05-2016 | Review Article

Role of Exercise-Induced Oxidative Stress in Sickle Cell Trait and Disease

Authors: Erica N. Chirico, Camille Faës, Philippe Connes, Emmanuelle Canet-Soulas, Cyril Martin, Vincent Pialoux

Published in: Sports Medicine | Issue 5/2016

Abstract

Sickle cell disease is a class of hemoglobinopathy in humans, which is the most common inherited disease in the world. Although complications of sickle cell disease start from polymerization of red blood cells during its deoxygenating phase, the oxidative stress resulting from the biological processes associated with this disease (ischaemic and hypoxic injuries, hemolysis and inflammation) has been shown to contribute to its pathophysiology. It is widely known that chronic exercise reduces oxidative stress in healthy people, mainly via improvement of antioxidant enzyme efficiency. In addition, recent studies in other diseases, as well as in sickle cell trait carriers and in a mouse model of sickle cell disease, have shown that regular physical activity could decrease oxidative stress. The purpose of this review is to summarize the role of oxidative stress in sickle cell disease and the effects of acute and chronic exercise on the pro-oxidant/antioxidant balance in sickle cell trait and sickle cell disease.

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Title: Role of Exercise-Induced Oxidative Stress in Sickle Cell Trait and Disease
Authors: Erica N. Chirico
Camille Faës
Philippe Connes
Emmanuelle Canet-Soulas
Cyril Martin
Vincent Pialoux
Publication date: 01-05-2016
Publisher: Springer International Publishing
Published in: Sports Medicine / Issue 5/2016
Print ISSN: 0112-1642
Electronic ISSN: 1179-2035
DOI: https://doi.org/10.1007/s40279-015-0447-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Role of Exercise-Induced Oxidative Stress in Sickle Cell Trait and Disease

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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Gold Standard or Fool’s Gold? The Efficacy of Displacement Variables as Indicators of Energy Expenditure in Team Sports

Validity of Submaximal Step Tests to Estimate Maximal Oxygen Uptake in Healthy Adults

Challenges Establishing the Efficacy of Exercise as an Antidepressant Treatment: A Systematic Review and Meta-Analysis of Control Group Responses in Exercise Randomised Controlled Trials

Muscle Weakness Thresholds for Prediction of Diabetes in Adults

Training Monitoring for Resistance Exercise: Theory and Applications

Intramuscular Anabolic Signaling and Endocrine Response Following Resistance Exercise: Implications for Muscle Hypertrophy