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Pediatric Drugs
Published in: Pediatric Drugs 5/2019

01-10-2019 | Xanthine Alkaloid | Review Article

Drug-Induced Urolithiasis in Pediatric Patients

Authors: Maria Chiara Sighinolfi, Ahmed Eissa, Luigi Bevilacqua, Ahmed Zoeir, Silvia Ciarlariello, Elena Morini, Stefano Puliatti, Viviana Durante, Pier Luca Ceccarelli, Salvatore Micali, Giampaolo Bianchi, Bernardo Rocco

Published in: Pediatric Drugs | Issue 5/2019

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Abstract

Drug-induced nephrolithiasis is a rare condition in children. The involved drugs may be divided into two different categories according to the mechanism involved in calculi formation. The first one includes poorly soluble drugs that favor the crystallization and calculi formation. The second category includes drugs that enhance calculi formation through their metabolic effects. The diagnosis of these specific calculi depends on a detailed medical history, associated comorbidities and the patient’s history of drug consumption. There are several risk factors associated with drug-induced stones, such as high dose of consumed drugs and long duration of treatment. Moreover, there are some specific risk factors, including urinary pH and the amount of fluid consumed by children. There are limited data regarding pediatric lithogenic drugs, and hence, our aim was to perform a comprehensive review of the literature to summarize these drugs and identify the possible mechanisms involved in calculi formation and discuss the management and preventive measures for these calculi.
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Metadata
Title
Drug-Induced Urolithiasis in Pediatric Patients
Authors
Maria Chiara Sighinolfi
Ahmed Eissa
Luigi Bevilacqua
Ahmed Zoeir
Silvia Ciarlariello
Elena Morini
Stefano Puliatti
Viviana Durante
Pier Luca Ceccarelli
Salvatore Micali
Giampaolo Bianchi
Bernardo Rocco
Publication date
01-10-2019
Publisher
Springer International Publishing
Published in
Pediatric Drugs / Issue 5/2019
Print ISSN: 1174-5878
Electronic ISSN: 1179-2019
DOI
https://doi.org/10.1007/s40272-019-00355-5

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DTaP-IPV-HepB-Hib Vaccine (Hexyon®): An Updated Review of its Use in Primary and Booster Vaccination

Original Research Article

Canakinumab in Children with Familial Mediterranean Fever: A Single-Center, Retrospective Analysis

Commentary

Good Pharmacovigilance Practice in Paediatrics: An Overview of the Updated European Medicines Agency Guidelines

Review Article

Bullous Diseases in Children: A Review of Clinical Features and Treatment Options

Original Research Article

Triclofos Sodium for Pediatric Sedation in Non-Painful Neurodiagnostic Studies