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Drugs & Aging
Published in: Drugs & Aging 11/2019

01-11-2019 | Giant Cell Arteritis | Review Article

Pathogenesis, Diagnosis and Management of Polymyalgia Rheumatica

Authors: Dario Camellino, Andrea Giusti, Giuseppe Girasole, Gerolamo Bianchi, Christian Dejaco

Published in: Drugs & Aging | Issue 11/2019

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Abstract

Polymyalgia rheumatica is an inflammatory rheumatic disease of the elderly characterised by pain and stiffness in the neck and pelvic girdle, and is the second most common inflammatory rheumatic condition in this age group, after rheumatoid arthritis. Polymyalgia rheumatica can occur independently or in association with giant cell arteritis, which is the most common form of primary vasculitis. The diagnosis of polymyalgia rheumatica is usually based on clinical presentation and increase of inflammatory markers. There are no pathognomonic findings that can confirm the diagnosis. However, different imaging techniques, especially ultrasonography, can assist in the identification of polymyalgia rheumatica. Glucocorticoids are the cornerstone of the treatment of polymyalgia rheumatica, but they might be associated with different adverse events. A subgroup of patients presents with a refractory disease course and, in these cases, adding methotrexate as a steroid-sparing agent could be useful. In this review, we summarise the latest findings regarding the pathogenesis, diagnosis and management of polymyalgia rheumatica and try to highlight the possible pitfalls, especially in elderly patients.
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Metadata
Title
Pathogenesis, Diagnosis and Management of Polymyalgia Rheumatica
Authors
Dario Camellino
Andrea Giusti
Giuseppe Girasole
Gerolamo Bianchi
Christian Dejaco
Publication date
01-11-2019
Publisher
Springer International Publishing
Published in
Drugs & Aging / Issue 11/2019
Print ISSN: 1170-229X
Electronic ISSN: 1179-1969
DOI
https://doi.org/10.1007/s40266-019-00705-5

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