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Published in: Drugs & Aging 2/2019

01-02-2019 | Leading Article

Parkinson’s Disease in the Era of Personalised Medicine: One Size Does Not Fit All

Authors: Lauren E. Ryden, Simon J. G. Lewis

Published in: Drugs & Aging | Issue 2/2019

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Abstract

The concept of personalised medicine in Parkinson’s disease has arrived where the implications of findings made in research are certain to have an increasing impact upon clinical practice. Disease heterogeneity in Parkinson’s disease has been well described and lends itself to the construct of personalised medicine where it is hypothesised that a greater understanding of genetic and pathophysiological contributions may underpin the sub-groups described. This in turn has driven the development of potentially individualised disease-modifying therapies where, for example, we are beginning to see treatments that target patients with Parkinson’s disease with specific genetic mutations. Furthermore, clinicians are increasingly recognising the need to tailor their management approach to patients depending on their age of presentation, acknowledging differential side-effect profiles and responses especially when considering the use of device-assisted technologies such as infusion or surgery. Clearly, individualising the treatment of both motor and non-motor symptoms will remain imperative but, in the future, personalised medicine may provide clearer insights into various aspects of a patient’s symptomatology, disease course and thus the best therapeutic approaches.
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Metadata
Title
Parkinson’s Disease in the Era of Personalised Medicine: One Size Does Not Fit All
Authors
Lauren E. Ryden
Simon J. G. Lewis
Publication date
01-02-2019
Publisher
Springer International Publishing
Published in
Drugs & Aging / Issue 2/2019
Print ISSN: 1170-229X
Electronic ISSN: 1179-1969
DOI
https://doi.org/10.1007/s40266-018-0624-5

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