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01-07-2019 | Breast Cancer | Review Article

Advances in Targeted Therapies for Triple-Negative Breast Cancer

Authors: Kelly E. McCann, Sara A. Hurvitz, Nicholas McAndrew

Published in: Drugs | Issue 11/2019

Abstract

While the outcomes for patients diagnosed with hormone receptor positive (HR+) and/or human epidermal growth factor receptor 2-positive (HER2+) breast cancers have continued to improve with the development of targeted therapies, the same cannot be said yet for those affected with triple-negative breast cancer (TNBC). Currently, the mainstay of treatment for the 10–15% of patients diagnosed with TNBC remains cytotoxic chemotherapy, but it is hoped that through an enhanced characterization of TNBC biology, this disease will be molecularly delineated into subgroups with targetable oncogenic drivers. This review will focus on recent therapeutic innovations for TNBC, including poly-ADP-ribosyl polymerase (PARP) inhibitors, phosphoinositide 3-kinase (PI3K) pathway inhibitors, immune checkpoint inhibitors, and cyclin-dependent kinase (CDK) inhibitors.

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Title: Advances in Targeted Therapies for Triple-Negative Breast Cancer
Authors: Kelly E. McCann
Sara A. Hurvitz
Nicholas McAndrew
Publication date: 01-07-2019
Publisher: Springer International Publishing
Keywords: Breast Cancer
Breast Cancer
Targeted Therapy
Cytostatic Therapy
Published in: Drugs / Issue 11/2019
Print ISSN: 0012-6667
Electronic ISSN: 1179-1950
DOI: https://doi.org/10.1007/s40265-019-01155-4

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Advances in Targeted Therapies for Triple-Negative Breast Cancer

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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