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Clinical Pharmacokinetics
Published in: Clinical Pharmacokinetics 11/2020

01-11-2020 | Pharmacokinetics | Original Research Article

Prediction of Maternal and Fetal Pharmacokinetics of Dolutegravir and Raltegravir Using Physiologically Based Pharmacokinetic Modeling

Authors: Xiaomei I. Liu, Jeremiah D. Momper, Natella Y. Rakhmanina, Dionna J. Green, Gilbert J. Burckart, Tim R. Cressey, Mark Mirochnick, Brookie M. Best, John N. van den Anker, André Dallmann

Published in: Clinical Pharmacokinetics | Issue 11/2020

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Abstract

Background

Predicting drug pharmacokinetics in pregnant women including placental drug transfer remains challenging. This study aimed to develop and evaluate maternal–fetal physiologically based pharmacokinetic models for two antiretroviral drugs, dolutegravir and raltegravir.
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Metadata
Title
Prediction of Maternal and Fetal Pharmacokinetics of Dolutegravir and Raltegravir Using Physiologically Based Pharmacokinetic Modeling
Authors
Xiaomei I. Liu
Jeremiah D. Momper
Natella Y. Rakhmanina
Dionna J. Green
Gilbert J. Burckart
Tim R. Cressey
Mark Mirochnick
Brookie M. Best
John N. van den Anker
André Dallmann
Publication date
01-11-2020
Publisher
Springer International Publishing
Published in
Clinical Pharmacokinetics / Issue 11/2020
Print ISSN: 0312-5963
Electronic ISSN: 1179-1926
DOI
https://doi.org/10.1007/s40262-020-00897-9

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