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Infection
Published in: Infection 6/2020

01-12-2020 | Coronavirus | Case Report

Utility of CT scan in patients with initial negative PCR for SARS-CoV2: a report of three cases

Authors: Kevin Bouiller, Sébastien Humbert, Camille Payet-Revest, Anne-Sophie Brunel, Adrien Mareshal, Quentin Lepiller, Franck Grillet, Catherine Chirouze

Published in: Infection | Issue 6/2020

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Abstract

PCR-based viral RNA to confirm the diagnosis of SARS-CoV-2 infection has a sensitivity of around 70%. We report three cases of patients with negative initial PCR and CT scan lesions that led us to suspect COVID-19, but which one(s) are really COVID-19?
Literature
1.
Wang W, Xu Y, Gao R, Lu R, Han K, Wu G, et al. Detection of SARS-CoV-2 in different types of clinical specimens. JAMA. 2020;323:1843–4.PubMedPubMedCentral
2.
Fang Y, Zhang H, Xie J, Lin M, Ying L, Pang P, et al. Sensitivity of chest CT for COVID-19: comparison to RT-PCR. Radiology. 2020;200432.
3.
Waller JV, Kaur P, Tucker A, Lin KK, Diaz MJ, Henry TS, et al. Diagnostic tools for coronavirus disease (COVID-19): comparing CT and RT-PCR viral nucleic acid testing. Am J Roentgenol. American Roentgen Ray Society; 2020;1–5.
4.
5.
Chan JF-W, Yuan S, Kok K-H, To KK-W, Chu H, Yang J, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet Lond Engl. 2020;395:514–23.CrossRef
6.
Zou L, Ruan F, Huang M, Liang L, Huang H, Hong Z, et al. SARS-CoV-2 viral load in upper respiratory specimens of infected patients. N Engl J Med. 2020;382:1177–9.CrossRef
7.
Wang X, Fang J, Zhu Y, Chen L, Ding F, Zhou R, et al. Clinical characteristics of non-critically ill patients with novel coronavirus infection (COVID-19) in a Fangcang Hospital. Clin Microbiol Infect. 2020. 
8.
Xu Y-H, Dong J-H, An W-M, Lv X-Y, Yin X-P, Zhang J-Z, et al. Clinical and computed tomographic imaging features of novel coronavirus pneumonia caused by SARS-CoV-2. J Infect. 2020;80:394–400.CrossRef
9.
Yang W, Cao Q, Qin L, Wang X, Cheng Z, Pan A, et al. Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19): a multi-center study in Wenzhou city, Zhejiang. China J Infect. 2020;80:388–93.CrossRef
10.
Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323:1061–9.CrossRef
11.
Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med. 2020;
Metadata
Title
Utility of CT scan in patients with initial negative PCR for SARS-CoV2: a report of three cases
Authors
Kevin Bouiller
Sébastien Humbert
Camille Payet-Revest
Anne-Sophie Brunel
Adrien Mareshal
Quentin Lepiller
Franck Grillet
Catherine Chirouze
Publication date
01-12-2020
Publisher
Springer Berlin Heidelberg
Published in
Infection / Issue 6/2020
Print ISSN: 0300-8126
Electronic ISSN: 1439-0973
DOI
https://doi.org/10.1007/s15010-020-01467-8

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