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Infection
Published in: Infection 6/2014

01-12-2014 | Brief Report

Detection and quantification of EBV, HHV-6 and CMV DNA in the gastrointestinal tract of HIV-positive patients

Authors: F. Falasca, P. Maida, A. Gaeta, S. Verzaro, I. Mezzaroma, A. Fantauzzi, G. Donato, E. Bonci, C. Castilletti, G. Antonelli, O. Turriziani

Published in: Infection | Issue 6/2014

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Abstract

Human herpes viruses (HHVs) have been frequently detected in the gastrointestinal (GI) tract and may contribute to the development of gastric cancer. In the present study, the detection rate and viral load of Epstein Barr virus (EBV), HHV-6 and Cytomegalovirus (CMV) were assessed in the GI tract of human immunodeficiency virus (HIV) positive patients and of uninfected patients. The analysis revealed a significantly higher detection rate of EBV and HHV-6 in HIV-infected individuals than in uninfected subjects (88.5 vs 63 %; p = 0.03). Moreover, EBV DNA load was significantly higher in the stomach of HIV patients than in controls. These data suggest that the HIV infection status may increase the persistence of these viruses in the GI compartment. Intriguingly, CMV DNA was undetectable in all biopsy specimens analyzed.
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Metadata
Title
Detection and quantification of EBV, HHV-6 and CMV DNA in the gastrointestinal tract of HIV-positive patients
Authors
F. Falasca
P. Maida
A. Gaeta
S. Verzaro
I. Mezzaroma
A. Fantauzzi
G. Donato
E. Bonci
C. Castilletti
G. Antonelli
O. Turriziani
Publication date
01-12-2014
Publisher
Springer Berlin Heidelberg
Published in
Infection / Issue 6/2014
Print ISSN: 0300-8126
Electronic ISSN: 1439-0973
DOI
https://doi.org/10.1007/s15010-014-0690-5

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