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Infection
Published in: Infection 1/2011

01-02-2011 | Clinical and Epidemiological Study

Causes of death and risk factors among HIV-infected persons in the HAART era: analysis of a large urban cohort

Published in: Infection | Issue 1/2011

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Abstract

Objective

We aimed to examine the clinical outcome in HIV-1-infected patients after more than 10 years of highly active antiretroviral therapy (HAART).

Methods

We analyzed data from 1,236 treatment-naïve adults who had started HAART. The primary endpoint was the yearly prevalence of death for AIDS-related causes (ARC) or for non-AIDS related causes (non-ARC). The data from our cohort were compared with that of the general population (GP) of our region.

Results

We observed that 116 patients died, and 58.6% of deaths were non-ARC. The death incidence decreased from 18.8% in 1998–1999 to 1.2% in 2008–2009. The leading causes of death were malignancies (35.3%), infections (21.6%), end-stage liver diseases (18.1%), and cardiovascular diseases (CVD) (6.9%). Yearly death rates were similar in the HIV-infected cohort and in the crude GP (odds ratio [OR] 1.1, 95% confidence interval [CI] 0.5–2.5), but when adjusted for age, HIV-infected patients showed a greater risk (OR 7.4, 95% CI 4.1–13.4). The difference was still highly significant when the analysis was restricted to non-ARCs (OR 4.3, 95% CI 2.07–9.2). Overall, malignancies (OR 5.7, 95% CI 2.6–12.8) and end-stage liver diseases (OR 35.0, 95% CI 15.5–78.8) were significantly more frequent than in the age-adjusted GP.

Conclusions

Despite HAART, HIV-infected patients are at greater risk of death compared to a reference uninfected population.
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Metadata
Title
Causes of death and risk factors among HIV-infected persons in the HAART era: analysis of a large urban cohort
Publication date
01-02-2011
Published in
Infection / Issue 1/2011
Print ISSN: 0300-8126
Electronic ISSN: 1439-0973
DOI
https://doi.org/10.1007/s15010-010-0079-z

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