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Current Obesity Reports

Published in:

01-12-2017 | Metabolism (CJ Billington, Section Editor)

Brown Adipose Tissue: an Update on Recent Findings

Authors: Kara L. Marlatt, Eric Ravussin

Published in: Current Obesity Reports | Issue 4/2017

Abstract

Purpose of Review

New treatment approaches to weight loss and weight loss maintenance in humans are critical. Given its potential role in stimulating energy expenditure, brown adipose tissue (BAT) activation has become a trending topic as an anti-obesity treatment.

Recent Findings

Most studies on BAT stimulation have been conducted in rodents and used cold stimulation. To date, few human trials exist that tested the effect of cold exposure on BAT. Those studies show that BAT contributes a small amount to overall energy metabolism which is unlikely to cause weight loss. Nonetheless, improvements in glucose metabolism have been demonstrated in humans. While new pharmacological approaches demonstrate some contribution of BAT to overall energy expenditure, the potential cardiovascular risk (increased heart rate and blood pressure to sustain the extra energy expenditure) may preclude their use.

Summary

There is no convincing evidence yet to indicate that BAT may be a viable pharmaceutical target for body weight loss or even weight loss maintenance. More research is needed to confirm the relevance of BAT and beige tissue to whole-body energy metabolism in humans.

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Title: Brown Adipose Tissue: an Update on Recent Findings
Authors: Kara L. Marlatt
Eric Ravussin
Publication date: 01-12-2017
Publisher: Springer US
Published in: Current Obesity Reports / Issue 4/2017
Electronic ISSN: 2162-4968
DOI: https://doi.org/10.1007/s13679-017-0283-6

ACC 2024 Congress Coverage

Heart Failure Video

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Brown Adipose Tissue: an Update on Recent Findings

Abstract

Purpose of Review

Recent Findings

Summary

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Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

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At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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