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Published in: Current Nutrition Reports 2/2019

01-06-2019 | Nutrition | Nutrition and the Brain (J Nasser, Section Editor)

Micronutrients and Brain Development

Authors: Davide Mattei, Angelo Pietrobelli

Published in: Current Nutrition Reports | Issue 2/2019

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Abstract

Purpose of Review

This review summarizes the most recent evidence regarding the effects of micronutrients on brain development.

Recent Findings

Emerging evidence indicates that nutrition in the early life can profoundly influence neurodevelopment, affecting later life health outcomes, neurocognitive performances, and disease risks. Inadequate early life nutrition has been associated with some neuropsychiatric disorders. Epigenetic mechanisms could play a crucial role, imprinting the genomes in early life making the individual more susceptible to develop diseases later in life.

Summary

Children adequately nourished are more likely to reach their developmental potential in cognitive, motor, and socioemotional abilities, with positive societal repercussions. Data from further clinical trials are needed before more definitive conclusions can be drawn regarding the efficacy of dietary interventions for improving neurocognitive and social outcomes and preventing some neuropsychiatric illnesses. Nevertheless, it is reasonable to make recommendations to our patients to adopt certain dietary habits to optimize early life nutritional status in order to avoid long-term adverse consequences. Strategies of prevention should focus on ensuring more quality food to preconceptional, pregnant, lactating women and to children in their early life, not only in those areas where malnutrition is common but also in developed countries.
Literature
5.
go back to reference Levi RS, Sanderson IR. Dietary regulation of gene expression. Curr Opin Gastroenterol. 2004;20:139–42.CrossRefPubMed Levi RS, Sanderson IR. Dietary regulation of gene expression. Curr Opin Gastroenterol. 2004;20:139–42.CrossRefPubMed
14.
go back to reference Bornstein MH. Sensitive periods in development: structural characteristics and causal interpretations. Psychol Bull. 1989;105:179–97.CrossRefPubMed Bornstein MH. Sensitive periods in development: structural characteristics and causal interpretations. Psychol Bull. 1989;105:179–97.CrossRefPubMed
15.
go back to reference Colombo J. The critical period concept: research, methodology, and theoretical issues. Psychol Bull. 1982;91:260–75.CrossRefPubMed Colombo J. The critical period concept: research, methodology, and theoretical issues. Psychol Bull. 1982;91:260–75.CrossRefPubMed
22.
go back to reference Susser ES, Lin SP. Schizophrenia after prenatal exposure to the Dutch Hunger Winter of 1944-1945. Arch Gen Psychiatry. 1992;49:983–8.CrossRefPubMed Susser ES, Lin SP. Schizophrenia after prenatal exposure to the Dutch Hunger Winter of 1944-1945. Arch Gen Psychiatry. 1992;49:983–8.CrossRefPubMed
23.
go back to reference Susser E, Neugebauer R, Hoek HW, Brown AS, Lin S, Labovitz D, et al. Schizophrenia after prenatal famine. Further evidence. Arch Gen Psychiatry. 1996;53:25–31.CrossRefPubMed Susser E, Neugebauer R, Hoek HW, Brown AS, Lin S, Labovitz D, et al. Schizophrenia after prenatal famine. Further evidence. Arch Gen Psychiatry. 1996;53:25–31.CrossRefPubMed
26.
go back to reference Toledo-Rodriguez M, Lotfipour S, Leonard G, Perron M, Richer L, Veillette S, et al. Maternal smoking during pregnancy is associated with epigenetic modifications of the brain-derived neurotrophic factor-6 exon in adolescent offspring. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:1350–4. https://doi.org/10.1002/ajmg.b.31109.CrossRefPubMed Toledo-Rodriguez M, Lotfipour S, Leonard G, Perron M, Richer L, Veillette S, et al. Maternal smoking during pregnancy is associated with epigenetic modifications of the brain-derived neurotrophic factor-6 exon in adolescent offspring. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:1350–4. https://​doi.​org/​10.​1002/​ajmg.​b.​31109.CrossRefPubMed
31.
32.
go back to reference Società di Nutrizione Umana (SINU). LARN—Livelli di Assunzione di Riferimento di Nutrienti ed Energia per la Popolazione Italiana; IV Revisione. Milano: SICS; 2014. p. 1–655. Società di Nutrizione Umana (SINU). LARN—Livelli di Assunzione di Riferimento di Nutrienti ed Energia per la Popolazione Italiana; IV Revisione. Milano: SICS; 2014. p. 1–655.
33.
go back to reference Ross AC, Taylor CL, Yaktine AL, et al. Dietary reference intakes for calciumand vitaminD. Institute ofMedicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium. National Academies Press (US); 2011. Summary tables. Ross AC, Taylor CL, Yaktine AL, et al. Dietary reference intakes for calciumand vitaminD. Institute ofMedicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium. National Academies Press (US); 2011. Summary tables.
44.
go back to reference Nguyen PH, Gonzalez-Casanova I, Young MF, Truong TV, Hoang H, Nguyen H, et al. Preconception micronutrient supplementation with iron and folic acid compared with folic acid alone affects linear growth and fine motor development at 2 years of age: a randomized controlled trial in Vietnam. J Nutr. 2017;147:1593–601. https://doi.org/10.3945/jn.117.250597.CrossRefPubMed Nguyen PH, Gonzalez-Casanova I, Young MF, Truong TV, Hoang H, Nguyen H, et al. Preconception micronutrient supplementation with iron and folic acid compared with folic acid alone affects linear growth and fine motor development at 2 years of age: a randomized controlled trial in Vietnam. J Nutr. 2017;147:1593–601. https://​doi.​org/​10.​3945/​jn.​117.​250597.CrossRefPubMed
62.
73.
go back to reference AbelMH, Ystrom E, Caspersen IH, Meltzer HM, Aase H, Torheim LE, et al. Maternal iodine intake and offspring attention-deficit/hyperactivity disorder: results froma large prospective cohort study. Nutrients. 2017;9:1239. https://doi.org/10.3390/nu9111239. AbelMH, Ystrom E, Caspersen IH, Meltzer HM, Aase H, Torheim LE, et al. Maternal iodine intake and offspring attention-deficit/hyperactivity disorder: results froma large prospective cohort study. Nutrients. 2017;9:1239. https://​doi.​org/​10.​3390/​nu9111239.
75.
76.
go back to reference Sandstead HHWO. Atwater memorial lecture. Zinc: essentiality for brain development and function. Nutr Rev. 1985;43:129–37.CrossRefPubMed Sandstead HHWO. Atwater memorial lecture. Zinc: essentiality for brain development and function. Nutr Rev. 1985;43:129–37.CrossRefPubMed
78.
go back to reference Mathur NB, Agarwal DK. Zinc supplementation in preterm neonates and neurological development, a randomized controlled trial. Indian Pediatr. 2015;52:951–5.CrossRefPubMed Mathur NB, Agarwal DK. Zinc supplementation in preterm neonates and neurological development, a randomized controlled trial. Indian Pediatr. 2015;52:951–5.CrossRefPubMed
80.
go back to reference Siegel EH, Kordas K, Stoltzfus RJ, Katz J, Khatry SK, LeClerq SC, et al. Inconsistent effects of iron-folic acid and/or zinc supplementation on the cognitive development of infants. J Health Popul Nutr. 2011;29:593–604.PubMedPubMedCentral Siegel EH, Kordas K, Stoltzfus RJ, Katz J, Khatry SK, LeClerq SC, et al. Inconsistent effects of iron-folic acid and/or zinc supplementation on the cognitive development of infants. J Health Popul Nutr. 2011;29:593–604.PubMedPubMedCentral
81.
go back to reference Locks LM, Manji KP, McDonald CM, Kupka R, Kisenge R, Aboud S, et al. The effect of daily zinc and/or multivitamin supplements on early childhood development in Tanzania: results from a randomized controlled trial. Matern Child Nutr. 2017;13:e12306. https://doi.org/10.1111/mcn.12306. Locks LM, Manji KP, McDonald CM, Kupka R, Kisenge R, Aboud S, et al. The effect of daily zinc and/or multivitamin supplements on early childhood development in Tanzania: results from a randomized controlled trial. Matern Child Nutr. 2017;13:e12306. https://​doi.​org/​10.​1111/​mcn.​12306.
85.
go back to reference Elbaz F, Zahra S, Hanafy H. Magnesium, zinc and copper estimation in children with attention deficit hyperactivity disorder (ADHD). Egypt J Med Human Genet. 2017;18(2):153–63.CrossRef Elbaz F, Zahra S, Hanafy H. Magnesium, zinc and copper estimation in children with attention deficit hyperactivity disorder (ADHD). Egypt J Med Human Genet. 2017;18(2):153–63.CrossRef
Metadata
Title
Micronutrients and Brain Development
Authors
Davide Mattei
Angelo Pietrobelli
Publication date
01-06-2019
Publisher
Springer US
Published in
Current Nutrition Reports / Issue 2/2019
Electronic ISSN: 2161-3311
DOI
https://doi.org/10.1007/s13668-019-0268-z

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