Skip to main content
Top
Published in: Current Nutrition Reports 3/2016

01-09-2016 | Gastroenterology, Critical Care, and Lifestyle Medicine (SA McClave, Section Editor)

The Health Benefits of Exercise and Physical Activity

Authors: Keith R. Miller, Stephen A. McClave, Melina B. Jampolis, Ryan T. Hurt, Kristine Krueger, Sarah Landes, Bryan Collier

Published in: Current Nutrition Reports | Issue 3/2016

Login to get access

Abstract

Physical inactivity is a modifiable risk factor (similar to dyslipidemia and hypertension) for a variety of chronic diseases, including cancer and cardiovascular disease. Exercise provides a clear health benefit, which serves in the primary and secondary prevention of these disease processes (the most important being a reduction in cardiovascular disease and premature death). The physiologic mechanisms for such a benefit occur at both a cellular and multisystem level. Prolonged periods of occupational or leisure-time sitting have adverse health effects independent of exercise performed before or after. Almost any form of physical activity (PA) is beneficial, whether part of a regular exercise program or as a series of intermittent, incidental, non-purposeful, lifestyle-embedded activity (causing non-exercise activity thermogenesis or NEAT). The health benefits of exercise appear to be dose-dependent. Physicians should recommend near daily exercise which includes at various times strength training, stretching, and aerobic activity in addition to emphasizing adjustments that allow for reduced sitting and increased activity during daily routines. Patients should understand that for optimal health, exercise is no longer optional.
Literature
1.
go back to reference Rezende LF, Rey Lopez JP, Matsudo VK, Luiz OD. Sedentary behavior and health outcomes among older adults: a systematic review. BMC Public Health. 2014;14(1):333.CrossRefPubMedPubMedCentral Rezende LF, Rey Lopez JP, Matsudo VK, Luiz OD. Sedentary behavior and health outcomes among older adults: a systematic review. BMC Public Health. 2014;14(1):333.CrossRefPubMedPubMedCentral
5.•
go back to reference Garatachea N, Pareja-Galeano H, Sanchis-Gomar F, Santos-Lozano A, Fiuza-Luces C, Morán M, et al. Exercise attenuates the major hallmarks of aging. Rejuvenation Res. 2015;18(1):57–89. Discussion regarding the exercise mediated attenuation of physical fitness and functional decline in aging. Garatachea N, Pareja-Galeano H, Sanchis-Gomar F, Santos-Lozano A, Fiuza-Luces C, Morán M, et al. Exercise attenuates the major hallmarks of aging. Rejuvenation Res. 2015;18(1):57–89. Discussion regarding the exercise mediated attenuation of physical fitness and functional decline in aging.
7.
go back to reference Blumenthal JA, Babyak MA, Moore KA, Craighead WE, Herman S, Khatri P, et al. Effects of exercise training on older patients with major depression. Arch Intern Med. 1999;159(19):2349–56.CrossRefPubMed Blumenthal JA, Babyak MA, Moore KA, Craighead WE, Herman S, Khatri P, et al. Effects of exercise training on older patients with major depression. Arch Intern Med. 1999;159(19):2349–56.CrossRefPubMed
8.
go back to reference Byrne A, Byrne DG. The effect of exercise on depression, anxiety and other mood states: a review. J Psychosom Res. 1993;37(6):565–74.CrossRefPubMed Byrne A, Byrne DG. The effect of exercise on depression, anxiety and other mood states: a review. J Psychosom Res. 1993;37(6):565–74.CrossRefPubMed
9.
go back to reference Macera CA, Hootman JM, Sniezek JE. Major public health benefits of physical activity. Arthritis Rheum. 2003;49(1):122–8.CrossRefPubMed Macera CA, Hootman JM, Sniezek JE. Major public health benefits of physical activity. Arthritis Rheum. 2003;49(1):122–8.CrossRefPubMed
10.
go back to reference Blair SN, Kohl 3rd HW, Paffenbarger Jr RS, Clark DG, Cooper KH, Gibbons LW. Physical fitness and all-cause mortality. A prospective study of healthy men and women. JAMA. 1989;262(17):2395–401.CrossRefPubMed Blair SN, Kohl 3rd HW, Paffenbarger Jr RS, Clark DG, Cooper KH, Gibbons LW. Physical fitness and all-cause mortality. A prospective study of healthy men and women. JAMA. 1989;262(17):2395–401.CrossRefPubMed
11.
go back to reference Hu FB, Willett WC, Li T, Stampfer MJ, Colditz GA, Manson JE. Adiposity as compared with physical activity in predicting mortality among women. N Engl J Med. 2004;351(26):2694–703.CrossRefPubMed Hu FB, Willett WC, Li T, Stampfer MJ, Colditz GA, Manson JE. Adiposity as compared with physical activity in predicting mortality among women. N Engl J Med. 2004;351(26):2694–703.CrossRefPubMed
12.
go back to reference Taylor RS, Brown A, Ebrahim S, Jolliffe J, Noorani H, Rees K, et al. Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials. Am J Med. 2004;116(10):682–92.CrossRefPubMed Taylor RS, Brown A, Ebrahim S, Jolliffe J, Noorani H, Rees K, et al. Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials. Am J Med. 2004;116(10):682–92.CrossRefPubMed
13.
go back to reference Hambrecht R, Niebauer J, Marburger C, Grunze M, Kälberer B, Hauer K, et al. Various intensities of leisure time physical activity in patients with coronary artery disease: effects on cardiorespiratory fitness and progression of coronary atherosclerotic lesions. J Am Coll Cardiol. 1993;22(2):468–77.CrossRefPubMed Hambrecht R, Niebauer J, Marburger C, Grunze M, Kälberer B, Hauer K, et al. Various intensities of leisure time physical activity in patients with coronary artery disease: effects on cardiorespiratory fitness and progression of coronary atherosclerotic lesions. J Am Coll Cardiol. 1993;22(2):468–77.CrossRefPubMed
14.
go back to reference Sarzynski MA1, Burton J2, Rankinen T2, Blair SN3, Church TS2, Després JP4, et al. The effects of exercise on the lipoprotein subclass profile: a meta-analysis of 10 interventions. Atherosclerosis. 2015;243(2):364–72.CrossRefPubMed Sarzynski MA1, Burton J2, Rankinen T2, Blair SN3, Church TS2, Després JP4, et al. The effects of exercise on the lipoprotein subclass profile: a meta-analysis of 10 interventions. Atherosclerosis. 2015;243(2):364–72.CrossRefPubMed
15.
go back to reference Hu FB, Stampfer MJ, Colditz GA, Ascherio A, Rexrode KM, Willett WC, et al. Physical activity and risk of stroke in women. JAMA. 2000;283(22):2961–7.CrossRefPubMed Hu FB, Stampfer MJ, Colditz GA, Ascherio A, Rexrode KM, Willett WC, et al. Physical activity and risk of stroke in women. JAMA. 2000;283(22):2961–7.CrossRefPubMed
16.
go back to reference Helmrich SP, Ragland DR, Leung RW, Paffenbarger Jr RS. Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N Engl J Med. 1991;325(3):147–52.CrossRefPubMed Helmrich SP, Ragland DR, Leung RW, Paffenbarger Jr RS. Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N Engl J Med. 1991;325(3):147–52.CrossRefPubMed
17.
go back to reference Gregg EW, Gerzoff RB, Caspersen CJ, Williamson DF, Narayan KM. Relationship of walking to mortality among US adults with diabetes. Arch Intern Med. 2003;163(12):1440–7.CrossRefPubMed Gregg EW, Gerzoff RB, Caspersen CJ, Williamson DF, Narayan KM. Relationship of walking to mortality among US adults with diabetes. Arch Intern Med. 2003;163(12):1440–7.CrossRefPubMed
18.
go back to reference Boulé NG, Haddad E, Kenny GP, Wells GA, Sigal RJ. Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials. JAMA. 2001;286(10):1218–27.CrossRefPubMed Boulé NG, Haddad E, Kenny GP, Wells GA, Sigal RJ. Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials. JAMA. 2001;286(10):1218–27.CrossRefPubMed
19.
go back to reference Thune I, Furberg AS. Physical activity and cancer risk: dose-response and cancer, all sites and site-specific. Med Sci Sports Exerc. 2001;33(6 Suppl):S530–50. discussion S609-10.CrossRefPubMed Thune I, Furberg AS. Physical activity and cancer risk: dose-response and cancer, all sites and site-specific. Med Sci Sports Exerc. 2001;33(6 Suppl):S530–50. discussion S609-10.CrossRefPubMed
20.
go back to reference Lee IM. Physical activity and cancer prevention—data from epidemiologic studies. Med Sci Sports Exerc. 2003;35(11):1823–7.CrossRefPubMed Lee IM. Physical activity and cancer prevention—data from epidemiologic studies. Med Sci Sports Exerc. 2003;35(11):1823–7.CrossRefPubMed
21.
go back to reference Holmes MD, Chen WY, Feskanich D, Kroenke CH, Colditz GA. Physical activity and survival after breast cancer diagnosis. JAMA. 2005;293(20):2479–86.CrossRefPubMed Holmes MD, Chen WY, Feskanich D, Kroenke CH, Colditz GA. Physical activity and survival after breast cancer diagnosis. JAMA. 2005;293(20):2479–86.CrossRefPubMed
22.
go back to reference Wolff I, van Croonenborg JJ, Kemper HC, Kostense PJ, Twisk JW. The effect of exercise training programs on bone mass: a meta-analysis of published controlled trials in pre- and postmenopausal women. Osteoporos Int. 1999;9(1):1–12.CrossRefPubMed Wolff I, van Croonenborg JJ, Kemper HC, Kostense PJ, Twisk JW. The effect of exercise training programs on bone mass: a meta-analysis of published controlled trials in pre- and postmenopausal women. Osteoporos Int. 1999;9(1):1–12.CrossRefPubMed
23.
go back to reference Kujala UM, Kaprio J, Kannus P, Sarna S, Koskenvuo M. Physical activity and osteoporotic hip fracture risk in men. Arch Intern Med. 2000;160(5):705–8.CrossRefPubMed Kujala UM, Kaprio J, Kannus P, Sarna S, Koskenvuo M. Physical activity and osteoporotic hip fracture risk in men. Arch Intern Med. 2000;160(5):705–8.CrossRefPubMed
24.
go back to reference Liu-Ambrose TY, Khan KM, Eng JJ, Heinonen A, McKay HA. Both resistance and agility training increase cortical bone density in 75- to 85-year-old women with low bone mass: a 6-month randomized controlled trial. J Clin Densitom. 2004;7(4):390–8.CrossRefPubMed Liu-Ambrose TY, Khan KM, Eng JJ, Heinonen A, McKay HA. Both resistance and agility training increase cortical bone density in 75- to 85-year-old women with low bone mass: a 6-month randomized controlled trial. J Clin Densitom. 2004;7(4):390–8.CrossRefPubMed
25.
go back to reference Feskanich D, Willett W, Colditz G. Walking and leisure-time activity and risk of hip fracture in postmenopausal women. JAMA. 2002;288(18):2300–6.CrossRefPubMed Feskanich D, Willett W, Colditz G. Walking and leisure-time activity and risk of hip fracture in postmenopausal women. JAMA. 2002;288(18):2300–6.CrossRefPubMed
26.
go back to reference Ranjbar E, Memari AH, Hafizi S, Shayestehfar M, Mirfazeli FS. Eshghi MA. J Sports Med. 2015;6(2):e24055. Ranjbar E, Memari AH, Hafizi S, Shayestehfar M, Mirfazeli FS. Eshghi MA. J Sports Med. 2015;6(2):e24055.
27.
go back to reference Cloud J. Why exercise won’t make you thin. Time. 2009;174(6):49–51. Cloud J. Why exercise won’t make you thin. Time. 2009;174(6):49–51.
28.
go back to reference Swift DL, Johannsen NM, Lavie CJ, Earnest CP, Church TS. The role of exercise and physical activity in weight loss and maintenance. Prog Cardiovasc Dis. 2014;56(4):441–7.CrossRefPubMed Swift DL, Johannsen NM, Lavie CJ, Earnest CP, Church TS. The role of exercise and physical activity in weight loss and maintenance. Prog Cardiovasc Dis. 2014;56(4):441–7.CrossRefPubMed
29.
go back to reference Donnelly JE, Blair SN, Jakicic JM, Manore MM, Rankin JW, Smith BK. American College of Sports Medicine. American College of Sports Medicine Position Stand. Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults. Med Sci Sports Exerc. 2009;41(2):459–71.CrossRefPubMed Donnelly JE, Blair SN, Jakicic JM, Manore MM, Rankin JW, Smith BK. American College of Sports Medicine. American College of Sports Medicine Position Stand. Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults. Med Sci Sports Exerc. 2009;41(2):459–71.CrossRefPubMed
30.
go back to reference Church TS, Martin CK, Thompson AM, Earnest CP, Mikus CR, Blair SN. Changes in weight, waist circumference and compensatory responses with different doses of exercise among sedentary, overweight postmenopausal women. PLoS One. 2009;4(2):e4515.CrossRefPubMedPubMedCentral Church TS, Martin CK, Thompson AM, Earnest CP, Mikus CR, Blair SN. Changes in weight, waist circumference and compensatory responses with different doses of exercise among sedentary, overweight postmenopausal women. PLoS One. 2009;4(2):e4515.CrossRefPubMedPubMedCentral
31.
go back to reference Miller CT, Fraser SF, Levinger I, Straznicky NE, Dixon JB, Reynolds J, et al. The effects of exercise training in addition to energy restriction on functional capacities and body composition in obese adults during weight loss: a systematic review. PLoS One. 2013;8(11):e81692.CrossRefPubMedPubMedCentral Miller CT, Fraser SF, Levinger I, Straznicky NE, Dixon JB, Reynolds J, et al. The effects of exercise training in addition to energy restriction on functional capacities and body composition in obese adults during weight loss: a systematic review. PLoS One. 2013;8(11):e81692.CrossRefPubMedPubMedCentral
32.
go back to reference Hill JO, Thompson H, Wyatt H. Weight maintenance: what’s missing? J Am Diet Assoc. 2005;105(5 Suppl 1):S63–6.CrossRefPubMed Hill JO, Thompson H, Wyatt H. Weight maintenance: what’s missing? J Am Diet Assoc. 2005;105(5 Suppl 1):S63–6.CrossRefPubMed
33.
go back to reference Steffens D, Maher CG, Pereira LS, Stevens ML, Oliveira VC, Chapple M, et al. Prevention of low back pain: a systematic review and meta-analysis. JAMA Intern Med. 2016;176(2):199–208.CrossRefPubMed Steffens D, Maher CG, Pereira LS, Stevens ML, Oliveira VC, Chapple M, et al. Prevention of low back pain: a systematic review and meta-analysis. JAMA Intern Med. 2016;176(2):199–208.CrossRefPubMed
34.
go back to reference Myers J, Kaykha A, George S, Abella J, Zaheer N, Lear S, et al. Fitness versus physical activity patterns in predicting mortality in men. Am J Med. 2004;117(12):912–8.CrossRefPubMed Myers J, Kaykha A, George S, Abella J, Zaheer N, Lear S, et al. Fitness versus physical activity patterns in predicting mortality in men. Am J Med. 2004;117(12):912–8.CrossRefPubMed
35.
go back to reference Warburton DE, Gledhill N, Quinney A. Musculoskeletal fitness and health. Can J Appl Physiol. 2001;26(2):217–37.CrossRefPubMed Warburton DE, Gledhill N, Quinney A. Musculoskeletal fitness and health. Can J Appl Physiol. 2001;26(2):217–37.CrossRefPubMed
36.•
go back to reference Buckley JP, Hedge A, Yates T, Copeland RJ, Loosemore M, Hamer M, et al. The sedentary office: an expert statement on the growing case for change towards better health and productivity. Br J Sports Med. 2015;49(21):1357–62. Expert consensus on techniques to combat increased periods of sitting and inactivity in the modern workplace. Buckley JP, Hedge A, Yates T, Copeland RJ, Loosemore M, Hamer M, et al. The sedentary office: an expert statement on the growing case for change towards better health and productivity. Br J Sports Med. 2015;49(21):1357–62. Expert consensus on techniques to combat increased periods of sitting and inactivity in the modern workplace.
37.
go back to reference Tremblay MS, Esliger DW, Tremblay A, Colley R. Incidental movement, lifestyle-embedded activity and sleep: new frontiers in physical activity assessment. Can J Public Health. 2007;98 Suppl 2:S208–17.PubMed Tremblay MS, Esliger DW, Tremblay A, Colley R. Incidental movement, lifestyle-embedded activity and sleep: new frontiers in physical activity assessment. Can J Public Health. 2007;98 Suppl 2:S208–17.PubMed
38.
39.
40.
go back to reference Bouchard C, Tremblay A. Genetic influences on the response of body fat and fat distribution to positive and negative energy balances in human identical twins. J Nutr. 1997;127(5 Suppl):943S–7S.PubMed Bouchard C, Tremblay A. Genetic influences on the response of body fat and fat distribution to positive and negative energy balances in human identical twins. J Nutr. 1997;127(5 Suppl):943S–7S.PubMed
41.
go back to reference Hill JO, Wyatt HR, Reed GW, Peters JC. Obesity and the environment: where do we go from here? Science. 2003;299(5608):853–5.CrossRefPubMed Hill JO, Wyatt HR, Reed GW, Peters JC. Obesity and the environment: where do we go from here? Science. 2003;299(5608):853–5.CrossRefPubMed
42.
go back to reference Campbell L, Wallman K, Green D. The effects of intermittent exercise on physiological outcomes in an obese population: continuous versus interval walking. J Sports Sci Med. 2010;9(1):24–30.PubMed Campbell L, Wallman K, Green D. The effects of intermittent exercise on physiological outcomes in an obese population: continuous versus interval walking. J Sports Sci Med. 2010;9(1):24–30.PubMed
43.
go back to reference Fisher G, Brown AW, Bohan Brown MM, Alcorn A, Noles C, Winwood L, et al. High intensity interval- vs moderate intensity-training for improving cardiometabolic health in overweight or obese males: a randomized controlled trial. PLoS One. 2015;10(10):e0138853.CrossRefPubMedPubMedCentral Fisher G, Brown AW, Bohan Brown MM, Alcorn A, Noles C, Winwood L, et al. High intensity interval- vs moderate intensity-training for improving cardiometabolic health in overweight or obese males: a randomized controlled trial. PLoS One. 2015;10(10):e0138853.CrossRefPubMedPubMedCentral
44.
go back to reference Tudor-Locke C, Bassett Jr DR. How many steps/day are enough? Preliminary pedometer indices for public health. Sports Med. 2004;34(1):1–8.CrossRefPubMed Tudor-Locke C, Bassett Jr DR. How many steps/day are enough? Preliminary pedometer indices for public health. Sports Med. 2004;34(1):1–8.CrossRefPubMed
45.
go back to reference Morris PE, Goad A, Thompson C, Taylor K, Harry B, Passmore L, et al. Early intensive care unit mobility therapy in the treatment of acute respiratory failure. Crit Care Med. 2008;36(8):2238–43.CrossRefPubMed Morris PE, Goad A, Thompson C, Taylor K, Harry B, Passmore L, et al. Early intensive care unit mobility therapy in the treatment of acute respiratory failure. Crit Care Med. 2008;36(8):2238–43.CrossRefPubMed
46.
go back to reference Schweickert WD, Pohlman MC, Pohlman AS, Nigos C, Pawlik AJ, Esbrook CL, et al. Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet. 2009;373(9678):1874–82.CrossRefPubMed Schweickert WD, Pohlman MC, Pohlman AS, Nigos C, Pawlik AJ, Esbrook CL, et al. Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet. 2009;373(9678):1874–82.CrossRefPubMed
47.
go back to reference Paffenbarger Jr RS, Hyde RT, Wing AL, Hsieh CC. Physical activity, all-cause mortality, and longevity of college alumni. N Engl J Med. 1986;314(10):605–13.CrossRefPubMed Paffenbarger Jr RS, Hyde RT, Wing AL, Hsieh CC. Physical activity, all-cause mortality, and longevity of college alumni. N Engl J Med. 1986;314(10):605–13.CrossRefPubMed
48.
go back to reference Lynch J, Helmrich SP, Lakka TA, Kaplan GA, Cohen RD, Salonen R, et al. Moderately intense physical activities and high levels of cardiorespiratory fitness reduce the risk of non-insulin-dependent diabetes mellitus in middle-aged men. Arch Intern Med. 1996;156(12):1307–14.CrossRefPubMed Lynch J, Helmrich SP, Lakka TA, Kaplan GA, Cohen RD, Salonen R, et al. Moderately intense physical activities and high levels of cardiorespiratory fitness reduce the risk of non-insulin-dependent diabetes mellitus in middle-aged men. Arch Intern Med. 1996;156(12):1307–14.CrossRefPubMed
49.
go back to reference U.S. Department of Health and Human Services. Healthy People 2010: Understanding and improving health. 2nd ed. Washington DC: US Government Printing Office; 2000. U.S. Department of Health and Human Services. Healthy People 2010: Understanding and improving health. 2nd ed. Washington DC: US Government Printing Office; 2000.
50.
go back to reference Balady GJ, Weiner DA. Exercise testing for sports and the exercise prescription. Cardiol Clin. 1987;5(2):183–96.PubMed Balady GJ, Weiner DA. Exercise testing for sports and the exercise prescription. Cardiol Clin. 1987;5(2):183–96.PubMed
Metadata
Title
The Health Benefits of Exercise and Physical Activity
Authors
Keith R. Miller
Stephen A. McClave
Melina B. Jampolis
Ryan T. Hurt
Kristine Krueger
Sarah Landes
Bryan Collier
Publication date
01-09-2016
Publisher
Springer US
Published in
Current Nutrition Reports / Issue 3/2016
Electronic ISSN: 2161-3311
DOI
https://doi.org/10.1007/s13668-016-0175-5

Other articles of this Issue 3/2016

Current Nutrition Reports 3/2016 Go to the issue

Gastroenterology, Critical Care, and Lifestyle Medicine (SA McClave, Section Editor)

Principles of Healthful Eating

Gastroenterology, Critical Care, and Lifestyle Medicine (SA McClave, Section Editor)

Indirect Calorimetry: Is it Required to Maximize Patient Outcome from Nutrition Therapy?

Gastroenterology, Critical Care, and Lifestyle Medicine (SA McClave, Section Editor)

Universal Small Bore Connectors (ENFit) for Enteral Access: Implications for Clinical Practice

Gastroenterology, Critical Care, and Lifestyle Medicine (SA McClave, Section Editor)

Comparative Measures of Lean Body Tissues in the Clinical Setting