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Published in: Current Pulmonology Reports 1/2017

01-03-2017 | Nutrition in Clinical Care (J Patel, Section Editor)

Interstitial Lung Disease, Body Mass Index, Energy Expenditure and Malnutrition—a Review

Authors: Sylvia Rinaldi, Marco Mura, Janet Madill

Published in: Current Pulmonology Reports | Issue 1/2017

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Abstract

Purpose of Review

Interstitial lung disease (ILD) comprises a spectrum of chronic disorders that cause various degrees of inflammation or fibrosis in the pulmonary interstitium. Although limited, data exists on nutritional concerns in ILD. However, previous research has not fully explored the broad range of potential nutritional concerns in ILD and impacts on outcomes. The purpose of this review was to identify and describe the overall nutritional status and relating concerns within the ILD population.

Recent Findings

Appropriate weight management in this population may positively impact both pre- and post-transplant survival. Additionally, accounting for adequate muscle mass may predict better outcomes than considering body mass index alone. Current research has identified risk of malnutrition related to decreased muscle strength, increased energy expenditure, vitamin D deficiency, and increased risk of osteoporosis and osteopenia.

Summary

Current research is preliminary and further research is necessary to identify established nutritional complications in this population.
Literature
1.
go back to reference Bradley B, Branley HM, Egan JJ, Greaves MS, Hansell DM, Harrison NK, et al. Interstitial lung disease guideline: the British Thoracic Society in collaboration with the Thoracic Society of Australia and New Zealand and the Irish Thoracic Society. Thorax. 2008;63 Suppl 5:v1–58.PubMed Bradley B, Branley HM, Egan JJ, Greaves MS, Hansell DM, Harrison NK, et al. Interstitial lung disease guideline: the British Thoracic Society in collaboration with the Thoracic Society of Australia and New Zealand and the Irish Thoracic Society. Thorax. 2008;63 Suppl 5:v1–58.PubMed
2.
go back to reference Raghu G, Collard HR, Egan JJ, Martinez FJ, Behr J, Brown KK, et al. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med. 2011;183(6):788–824.PubMedPubMedCentral Raghu G, Collard HR, Egan JJ, Martinez FJ, Behr J, Brown KK, et al. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med. 2011;183(6):788–824.PubMedPubMedCentral
3.
go back to reference Travis WD, Costabel U, Hansell DM, King TE, Lynch DA, Nicholson AG, et al. An official American Thoracic Society/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med. 2013;188(6):733–48.CrossRefPubMedPubMedCentral Travis WD, Costabel U, Hansell DM, King TE, Lynch DA, Nicholson AG, et al. An official American Thoracic Society/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med. 2013;188(6):733–48.CrossRefPubMedPubMedCentral
4.
go back to reference Mura M, Porretta MA, Bargagli E, Sergiacomi G, Zompatori M, Sverzellati N, et al. Predicting survival in newly diagnosed idiopathic pulmonary fibrosis: a 3-year prospective study. Eur Respir J. 2012;40(1):101–9.PubMed Mura M, Porretta MA, Bargagli E, Sergiacomi G, Zompatori M, Sverzellati N, et al. Predicting survival in newly diagnosed idiopathic pulmonary fibrosis: a 3-year prospective study. Eur Respir J. 2012;40(1):101–9.PubMed
5.
go back to reference Collard H, King T, Bartelson B, Vourlekis J, Schwarz M. Changes in clinical and physiologic variables predict survival in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2003;168(5):538–42.PubMed Collard H, King T, Bartelson B, Vourlekis J, Schwarz M. Changes in clinical and physiologic variables predict survival in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2003;168(5):538–42.PubMed
6.
go back to reference Richeldi L, Davies HHRHR, Spagnolo P, Luppi F. Corticosteroids for idiopathic pulmonary fibrosis. The Cochrane Collaboration, Richeldi L, editors. Database Syst Rev. 2003;(3):1–13. Richeldi L, Davies HHRHR, Spagnolo P, Luppi F. Corticosteroids for idiopathic pulmonary fibrosis. The Cochrane Collaboration, Richeldi L, editors. Database Syst Rev. 2003;(3):1–13.
7.
go back to reference Spagnolo P, Del Giovane C, Luppi F, Cerri S, Balduzzi S, Walters EH, et al. Non-steroid agents for idiopathic pulmonary fibrosis. The Cochrane Collaboration, editor. Cochrane Database Syst Rev. 2010;(9):1–74. Spagnolo P, Del Giovane C, Luppi F, Cerri S, Balduzzi S, Walters EH, et al. Non-steroid agents for idiopathic pulmonary fibrosis. The Cochrane Collaboration, editor. Cochrane Database Syst Rev. 2010;(9):1–74.
8.
go back to reference Hunninghake GM. A new hope for idiopathic pulmonary fibrosis. N Engl J Med. 2014;370(22):2142–3.PubMed Hunninghake GM. A new hope for idiopathic pulmonary fibrosis. N Engl J Med. 2014;370(22):2142–3.PubMed
9.
go back to reference Richeldi L, du Bois RM, Raghu G, Azuma A, Brown KK, Costabel U, et al. Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. N Engl J Med. 2014;370(22):2071–82.PubMed Richeldi L, du Bois RM, Raghu G, Azuma A, Brown KK, Costabel U, et al. Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. N Engl J Med. 2014;370(22):2071–82.PubMed
10.
go back to reference Crockett AJ, Cranston JM, Antic N. Domiciliary oxygen for interstitial lung disease. The Cochrane Collaboration, Crockett A, editors. Cochrane Database Syst Rev. 2001;(3):CD002883. Crockett AJ, Cranston JM, Antic N. Domiciliary oxygen for interstitial lung disease. The Cochrane Collaboration, Crockett A, editors. Cochrane Database Syst Rev. 2001;(3):CD002883.
11.
go back to reference Holland AE, Hill C. Physical training for interstitial lung disease. The Cochrane Collaboration, Holland AE, editors. Cochrane Database Syst Rev. 2008;(4). Holland AE, Hill C. Physical training for interstitial lung disease. The Cochrane Collaboration, Holland AE, editors. Cochrane Database Syst Rev. 2008;(4).
12.
go back to reference Yusen RD, Christie JD, Edwards LB, Kucheryavaya AY, Benden C, Dipchand AI, et al. The registry of the international society for heart and lung transplantation: thirtieth adult lung and heart-lung transplant report—2013; focus theme: age. J Heart Lung Transplant. 2013;32(10):965–78.PubMed Yusen RD, Christie JD, Edwards LB, Kucheryavaya AY, Benden C, Dipchand AI, et al. The registry of the international society for heart and lung transplantation: thirtieth adult lung and heart-lung transplant report—2013; focus theme: age. J Heart Lung Transplant. 2013;32(10):965–78.PubMed
14.
go back to reference Madill J, Maurer JR, de Hoyos A. A comparison of preoperative and postoperative nutritional states of lung transplant recipients. Transplantation. 1993;56(2):347–50.PubMed Madill J, Maurer JR, de Hoyos A. A comparison of preoperative and postoperative nutritional states of lung transplant recipients. Transplantation. 1993;56(2):347–50.PubMed
15.
go back to reference Madill J, Gutierrez C, Grossman J, Allard J, Chan C, Hutcheon M, et al. Nutritional assessment of the lung transplant patient: body mass index as a predictor of 90-day mortality following transplantation. J Heart Lung Transplant. 2001;20(3):288–96.PubMed Madill J, Gutierrez C, Grossman J, Allard J, Chan C, Hutcheon M, et al. Nutritional assessment of the lung transplant patient: body mass index as a predictor of 90-day mortality following transplantation. J Heart Lung Transplant. 2001;20(3):288–96.PubMed
16.
go back to reference Culver DA, Mazzone PJ, Khandwala F, Blazey HC, Decamp MM, Chapman JT. Discordant utility of ideal body weight and body mass index as predictors of mortality in lung transplant recipients. J Heart Lung Transplant. 2005;24(2):137–44.PubMed Culver DA, Mazzone PJ, Khandwala F, Blazey HC, Decamp MM, Chapman JT. Discordant utility of ideal body weight and body mass index as predictors of mortality in lung transplant recipients. J Heart Lung Transplant. 2005;24(2):137–44.PubMed
17.
go back to reference Gries CJ, Bhadriraju S, Edelman JD, Goss CH, Raghu G, Mulligan MS. Obese patients with idiopathic pulmonary fibrosis have a higher 90-day mortality risk with bilateral lung transplantation. J Heart Lung Transplant. 2015;34(2):241–6.PubMed Gries CJ, Bhadriraju S, Edelman JD, Goss CH, Raghu G, Mulligan MS. Obese patients with idiopathic pulmonary fibrosis have a higher 90-day mortality risk with bilateral lung transplantation. J Heart Lung Transplant. 2015;34(2):241–6.PubMed
18.
go back to reference • Singer JP, Peterson ER, Snyder ME, Katz PP, Golden JA, D’Ovidio F, et al. Body composition and mortality after adult lung transplantation in the United States. Am J Respir Crit Care Med. 2014;190(9):1012–21. This study provides novel insight into the relationship between body composition and outcomes. Previous research mainly focuses on BMI, however, authors have shown that results based on BMI alone do not yield the same results when one accounts for skeletal muscle mass.PubMedPubMedCentral • Singer JP, Peterson ER, Snyder ME, Katz PP, Golden JA, D’Ovidio F, et al. Body composition and mortality after adult lung transplantation in the United States. Am J Respir Crit Care Med. 2014;190(9):1012–21. This study provides novel insight into the relationship between body composition and outcomes. Previous research mainly focuses on BMI, however, authors have shown that results based on BMI alone do not yield the same results when one accounts for skeletal muscle mass.PubMedPubMedCentral
19.
go back to reference Tynan C, Hasse JM. Current nutrition practices in adult lung transplantation. Nutr Clin Pract. 2004;19(6):587–96.PubMed Tynan C, Hasse JM. Current nutrition practices in adult lung transplantation. Nutr Clin Pract. 2004;19(6):587–96.PubMed
20.
go back to reference Alakhras M, Decker PA, Nadrous HF, Collazo-Clavell M, Ryu JH. Body mass index and mortality in patients with idiopathic pulmonary fibrosis. Chest. 2007;131(5):1448–53.PubMed Alakhras M, Decker PA, Nadrous HF, Collazo-Clavell M, Ryu JH. Body mass index and mortality in patients with idiopathic pulmonary fibrosis. Chest. 2007;131(5):1448–53.PubMed
21.
go back to reference Celli B, Cote C, Marin J, Casanova C, Montes de Oca M, Mendez R, et al. The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med. 2004;350(10):1005–12.PubMed Celli B, Cote C, Marin J, Casanova C, Montes de Oca M, Mendez R, et al. The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med. 2004;350(10):1005–12.PubMed
22.
go back to reference Cano N, Raphael J-C, Roth CM, Pichard C, Roth H, Isabelle C, et al. C-reactive protein and body mass index predict outcome in end-stage respiratory failure. Chest. 2004;126(2):540–6.PubMed Cano N, Raphael J-C, Roth CM, Pichard C, Roth H, Isabelle C, et al. C-reactive protein and body mass index predict outcome in end-stage respiratory failure. Chest. 2004;126(2):540–6.PubMed
23.
go back to reference Landbo C, Prescott E, Lange P, Vestbo J, Almdal TP. Prognostic value of nutritional status in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1999;160(6):1856–61.PubMed Landbo C, Prescott E, Lange P, Vestbo J, Almdal TP. Prognostic value of nutritional status in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1999;160(6):1856–61.PubMed
24.
go back to reference Schols AM, Slangen J, Volovics L, Wouters EF. Weight loss is a reversible factor in the prognosis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998;157(6 Pt 1):1791–7.PubMed Schols AM, Slangen J, Volovics L, Wouters EF. Weight loss is a reversible factor in the prognosis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1998;157(6 Pt 1):1791–7.PubMed
25.
go back to reference Chailleux E, Fauriux B, Binet F. Predictors of survival in patients receiving domiciliary oxygen therapy or mechanical ventilation: a 10-year analysis of ANTADIR Observatory. Chest. 1996;109(2):741–9.PubMed Chailleux E, Fauriux B, Binet F. Predictors of survival in patients receiving domiciliary oxygen therapy or mechanical ventilation: a 10-year analysis of ANTADIR Observatory. Chest. 1996;109(2):741–9.PubMed
26.
go back to reference Wilson DO, Rogers RM, Wright EC, Anthonisen NR. Body weight in chronic obstructive pulmonary disease. The National Institutes of Health Intermittent Positive-Pressure Breathing Trial. Am Rev Respir Dis. 1989;139(6):1435–8.PubMed Wilson DO, Rogers RM, Wright EC, Anthonisen NR. Body weight in chronic obstructive pulmonary disease. The National Institutes of Health Intermittent Positive-Pressure Breathing Trial. Am Rev Respir Dis. 1989;139(6):1435–8.PubMed
27.
go back to reference Gonzalez M, Pastore CA, Orlandi SP, Heymsfield SB. Obesity paradox in cancer: new insights provided by body composition. Am J Clin Nutr. 2014;99(5):999–1005.PubMed Gonzalez M, Pastore CA, Orlandi SP, Heymsfield SB. Obesity paradox in cancer: new insights provided by body composition. Am J Clin Nutr. 2014;99(5):999–1005.PubMed
28.
go back to reference • Mendes PO, Wickerson L, Helm DE, Janaudis-ferreira TA, Brooks D, Singer LIG, et al. Skeletal muscle atrophy in advanced interstitial lung disease. 2015;20(6):953–9. This study focuses on physical activity in ILD and provides novel data on physical functionality. Implications from this research is directly related to nutrition as exercise training and rehabiliation may be enhanced by adequate nutrition intake. • Mendes PO, Wickerson L, Helm DE, Janaudis-ferreira TA, Brooks D, Singer LIG, et al. Skeletal muscle atrophy in advanced interstitial lung disease. 2015;20(6):953–9. This study focuses on physical activity in ILD and provides novel data on physical functionality. Implications from this research is directly related to nutrition as exercise training and rehabiliation may be enhanced by adequate nutrition intake.
29.
go back to reference Cawood AL, Elia M, Stratton R. Systematic review and meta-analysis of the effects of high protein oral nutritional supplements. Ageing Res Rev. 2012;11(2):278–96.PubMed Cawood AL, Elia M, Stratton R. Systematic review and meta-analysis of the effects of high protein oral nutritional supplements. Ageing Res Rev. 2012;11(2):278–96.PubMed
30.
go back to reference Slinde F, Grönberg AM, Svantesson U, Hulthén L, Larsson S. Energy expenditure in chronic obstructive pulmonary disease-evaluation of simple measures. Eur J Clin Nutr. 2011;65(12):1309–13.PubMed Slinde F, Grönberg AM, Svantesson U, Hulthén L, Larsson S. Energy expenditure in chronic obstructive pulmonary disease-evaluation of simple measures. Eur J Clin Nutr. 2011;65(12):1309–13.PubMed
31.
go back to reference Nordenson A, Gronberg AM, Hulthen L, Larsson S, Slinde F. A validated disease specific prediction equation for resting metabolic rate in underweight patients with COPD. Int J Chron Obstruct Pulmon Dis. 2010;5:271–6.PubMedPubMedCentral Nordenson A, Gronberg AM, Hulthen L, Larsson S, Slinde F. A validated disease specific prediction equation for resting metabolic rate in underweight patients with COPD. Int J Chron Obstruct Pulmon Dis. 2010;5:271–6.PubMedPubMedCentral
32.
go back to reference Slinde F, Grönberg A, Svantesson U, Hulthén L, Larsson S. Energy expenditure in chronic obstructive pulmonary disease—evaluation of simple measures. Eur J Clin Nutr. 2011;65(12):1309–13.PubMed Slinde F, Grönberg A, Svantesson U, Hulthén L, Larsson S. Energy expenditure in chronic obstructive pulmonary disease—evaluation of simple measures. Eur J Clin Nutr. 2011;65(12):1309–13.PubMed
33.
go back to reference Ryerson CJ, Collard HR, Pantilat SZ. Management of dyspnea in interstitial lung disease. Curr Opin Support Palliat Care. 2010;4(2):69–75.PubMed Ryerson CJ, Collard HR, Pantilat SZ. Management of dyspnea in interstitial lung disease. Curr Opin Support Palliat Care. 2010;4(2):69–75.PubMed
34.
go back to reference Fitting J, Frascarolo P, Jequier E, Leuenberger P. Energy expenditure in interstitial lung disease. Am Rev Respir Dis. 1990;142(3):631–5.PubMed Fitting J, Frascarolo P, Jequier E, Leuenberger P. Energy expenditure in interstitial lung disease. Am Rev Respir Dis. 1990;142(3):631–5.PubMed
35.
go back to reference Norman K, Pichard C, Lochs H, Pirlich M. Prognostic impact of disease-related malnutrition. Clin Nutr. 2008;27(1):5–15.PubMed Norman K, Pichard C, Lochs H, Pirlich M. Prognostic impact of disease-related malnutrition. Clin Nutr. 2008;27(1):5–15.PubMed
36.
go back to reference Detsky A, McLaughlin JR, Baker J. What is subjective global assessment of nutritional status? JPEN. 1987;11(1):8–13. Detsky A, McLaughlin JR, Baker J. What is subjective global assessment of nutritional status? JPEN. 1987;11(1):8–13.
37.
go back to reference Günay E, Kaymaz D, Selçuk NT, Ergün P, Sengül F, Demir N. Effect of nutritional status in individuals with chronic obstructive pulmonary disease undergoing pulmonary rehabilitation. Respirology. 2013;18:1217–22.PubMed Günay E, Kaymaz D, Selçuk NT, Ergün P, Sengül F, Demir N. Effect of nutritional status in individuals with chronic obstructive pulmonary disease undergoing pulmonary rehabilitation. Respirology. 2013;18:1217–22.PubMed
38.
go back to reference Gupta B, Kant S, Mishra R. Subjective global assessment of nutritional status of chronic obstructive pulmonary disease patients on admission. Int J Tuberc Lung Dis. 2010;14(4):500–5.PubMed Gupta B, Kant S, Mishra R. Subjective global assessment of nutritional status of chronic obstructive pulmonary disease patients on admission. Int J Tuberc Lung Dis. 2010;14(4):500–5.PubMed
39.
go back to reference Autore K, Black T, Klesen M, Richards T, Gibson K, Kaminski N, et al. Evaluating nutritional status of patients with idiopathic pulmonary fibrosis: a prospective pilot study using the mini nutrition assessment short from. In: A42 Interstitial Lung Disease: Epidemiology, Evaluation and Pathogenesis. Philadelphia Pennsylvania: American Thoracic Society; 2013. p. A1461–A1461. Autore K, Black T, Klesen M, Richards T, Gibson K, Kaminski N, et al. Evaluating nutritional status of patients with idiopathic pulmonary fibrosis: a prospective pilot study using the mini nutrition assessment short from. In: A42 Interstitial Lung Disease: Epidemiology, Evaluation and Pathogenesis. Philadelphia Pennsylvania: American Thoracic Society; 2013. p. A1461–A1461.
40.
go back to reference Buhr G, Bales CW. Nutritional supplements for older adults: review and recommendations--Part II. J Nutr Elder. 2010;29(1):42–71.PubMed Buhr G, Bales CW. Nutritional supplements for older adults: review and recommendations--Part II. J Nutr Elder. 2010;29(1):42–71.PubMed
41.
go back to reference Buhr G, Bales CW. Nutritional supplements for older adults: review and recommendations—part I. J Nutr Elder. 2009;28(1):5–29.PubMed Buhr G, Bales CW. Nutritional supplements for older adults: review and recommendations—part I. J Nutr Elder. 2009;28(1):5–29.PubMed
42.
go back to reference McCaddon A. Vitamin B12 in neurology and ageing; clinical and genetic aspects. Biochimie. 2013;95(5):1066–76.PubMed McCaddon A. Vitamin B12 in neurology and ageing; clinical and genetic aspects. Biochimie. 2013;95(5):1066–76.PubMed
43.
go back to reference Arai T, Inoue Y, Sasaki Y, Tachibana K, Nakao K, Sugimoto C, et al. Predictors of the clinical effects of pirfenidone on idiopathic pulmonary fibrosis. Respir Investig. 2014;52:136–43.PubMed Arai T, Inoue Y, Sasaki Y, Tachibana K, Nakao K, Sugimoto C, et al. Predictors of the clinical effects of pirfenidone on idiopathic pulmonary fibrosis. Respir Investig. 2014;52:136–43.PubMed
44.
go back to reference de Groot L. Nutritional issues for older adults: addressing degenerative ageing with long-term studies. Proc Nutr Soc. 2016;75(2):169–73.PubMed de Groot L. Nutritional issues for older adults: addressing degenerative ageing with long-term studies. Proc Nutr Soc. 2016;75(2):169–73.PubMed
45.
go back to reference Lems WF, Van Veen GJ, Gerrits MI, Jacobs JW, Houben HH, Van Rijn HJ, et al. Effect of low-dose prednisone (with calcium and calcitriol supplementation) on calcium and bone metabolism in healthy volunteers. Br J Rheumatol. 1998;37(1):27–33.PubMed Lems WF, Van Veen GJ, Gerrits MI, Jacobs JW, Houben HH, Van Rijn HJ, et al. Effect of low-dose prednisone (with calcium and calcitriol supplementation) on calcium and bone metabolism in healthy volunteers. Br J Rheumatol. 1998;37(1):27–33.PubMed
46.
go back to reference Finklea JD, Grossmann RE, Tangpricha V. Vitamin D and chronic lung disease: a review of molecular mechanisms and clinical studies. Adv Nutr. 2011;2(3):244–53.PubMedPubMedCentral Finklea JD, Grossmann RE, Tangpricha V. Vitamin D and chronic lung disease: a review of molecular mechanisms and clinical studies. Adv Nutr. 2011;2(3):244–53.PubMedPubMedCentral
47.
go back to reference Hagaman J, Panos R, McCormack F, Thakar C, Wikenheiser-Brokamp K, Shipley R, et al. Vitamin D deficiency and reduced lung function in connective tissue-associated interstitial lung diseases. 2011;139(2):353–60. Hagaman J, Panos R, McCormack F, Thakar C, Wikenheiser-Brokamp K, Shipley R, et al. Vitamin D deficiency and reduced lung function in connective tissue-associated interstitial lung diseases. 2011;139(2):353–60.
48.
go back to reference Mascitelli L, Pezzetta F, Goldstein MR, Waschki B, Kirsten A. Vitamin D and mortality from pulmonary fibrosis a positive end-expiratory pressure effect. Chest. 2010;137(2):495–6.PubMed Mascitelli L, Pezzetta F, Goldstein MR, Waschki B, Kirsten A. Vitamin D and mortality from pulmonary fibrosis a positive end-expiratory pressure effect. Chest. 2010;137(2):495–6.PubMed
49.
go back to reference Olson A, Swigris J, Raghu G, Brown KK. Seasonal variation: mortality from pulmonary fibrosis is greatest in the winter. Chest. 2009;136(1):16–22.PubMed Olson A, Swigris J, Raghu G, Brown KK. Seasonal variation: mortality from pulmonary fibrosis is greatest in the winter. Chest. 2009;136(1):16–22.PubMed
50.
go back to reference Ramirez A, Wongtrakool C, Welch T, Steinmeyer A, Zugel U, Roman J. Vitamin D inhibition of pro-fibrotic effects of transforming growth factor beta1 in lung fibroblasts and epithelial cells. J Steroid Biochem Mol Biol. 2010;118(3):142–50.PubMed Ramirez A, Wongtrakool C, Welch T, Steinmeyer A, Zugel U, Roman J. Vitamin D inhibition of pro-fibrotic effects of transforming growth factor beta1 in lung fibroblasts and epithelial cells. J Steroid Biochem Mol Biol. 2010;118(3):142–50.PubMed
51.
go back to reference •• Alhamad EH, Nadama R. Bone mineral density in patients with interstitial lung disease. Sarcoidosis Vasc Diffuse Lung Dis. 2015;32:151–9. This study identified osteoporosis and ostepenia and a clinically signicant portion of their sample. Authors found that increasing age, UIP diagnosis, higher partial pressure of carbon dioxide, hypertension and diabetes.PubMed •• Alhamad EH, Nadama R. Bone mineral density in patients with interstitial lung disease. Sarcoidosis Vasc Diffuse Lung Dis. 2015;32:151–9. This study identified osteoporosis and ostepenia and a clinically signicant portion of their sample. Authors found that increasing age, UIP diagnosis, higher partial pressure of carbon dioxide, hypertension and diabetes.PubMed
Metadata
Title
Interstitial Lung Disease, Body Mass Index, Energy Expenditure and Malnutrition—a Review
Authors
Sylvia Rinaldi
Marco Mura
Janet Madill
Publication date
01-03-2017
Publisher
Springer US
Published in
Current Pulmonology Reports / Issue 1/2017
Electronic ISSN: 2199-2428
DOI
https://doi.org/10.1007/s13665-017-0168-x

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