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Dermatology and Therapy
Published in: Dermatology and Therapy 4/2017

Open Access 01-12-2017 | Case Report

Acute Localized Exanthematous Pustulosis (ALEP): Review of Literature with Report of Case Caused by Amoxicillin-Clavulanic Acid

Authors: Alessia Villani, Antonello Baldo, Gaia De Fata Salvatores, Vincenzo Desiato, Fabio Ayala, Carlo Donadio

Published in: Dermatology and Therapy | Issue 4/2017

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Abstract

Acute localized exanthematous pustulosis (ALEP) is a localized form of acute generalized exanthematous pustulosis, characterized by acute onset of multiple nonfollicular, pinhead-sized, sterile pustules following drug administration. Antibiotics, especially β-lactams and macrolides, have been implicated in the majority of cases, although eruption after nonsteroidal antiinflammatory drugs and many other medications has also been reported. Skin reaction arises quickly within a few hours, resolving rapidly within a few days without treatment, and it is usually accompanied by fever and neutrophilic leukocytosis. We report herein all cases of ALEP described in literature, adding the case of a 35-year-old woman admitted to our hospital with outbreak of erythematous pustules on her face, neck, and chest after amoxicillin–clavulanic acid treatment.
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Metadata
Title
Acute Localized Exanthematous Pustulosis (ALEP): Review of Literature with Report of Case Caused by Amoxicillin-Clavulanic Acid
Authors
Alessia Villani
Antonello Baldo
Gaia De Fata Salvatores
Vincenzo Desiato
Fabio Ayala
Carlo Donadio
Publication date
01-12-2017
Publisher
Springer Healthcare
Published in
Dermatology and Therapy / Issue 4/2017
Print ISSN: 2193-8210
Electronic ISSN: 2190-9172
DOI
https://doi.org/10.1007/s13555-017-0206-1

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