Published in:
01-10-2018 | Original Article
Association of PAX4 gene R192H polymorphisms in Chinese Han type 2 diabetes
Authors:
Fei Leng, Yan Ling, Gulibositan Aji, Fang Li, Jiachao Chen, Yu Luo, Jing Zhang, Ke Hu, Ziyun Cheng, Zhiqiang Lu
Published in:
International Journal of Diabetes in Developing Countries
|
Issue 4/2018
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Abstract
The purpose of this study was to explore whether PAX4 gene R192H polymorphism plays a role in type 2 diabetes in Chinese Han population, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technology to detect R192H polymorphism in exon 5 of PAX4 gene in 410 cases of patients with type 2 diabetes and 95 cases of non-diabetic controls from January 2014 to January 2015. There are no significant differences in the genotypes or allele frequencies between type 2 diabetes mellitus (T2DM) and non-diabetic controls about PAX4 R192H polymorphism. Similarly, no statistical differences were observed in the T2DM and non-diabetic controls when adjusting for gender stratification and age stratification. The comparisons on the subjects in clinical characteristics including blood glucose, glycated hemoglobin, cholesterol, triglycerides, high-density lipoprotein cholesterol, and systolic blood pressure showed no difference between carriers with the GA and AA genotype except diastolic blood pressure (p value = 0.038). PAX4 gene exon 5 R192H polymorphism was not associated with type 2 diabetes in Chinese Han population.