Association between single nucleotide polymorphisms (SNPs) in the gene of ADP-ribosylation factor-like 15 (ARL15) and type 2 diabetes (T2D) in Korean Chinese population in Yanbian, China

This study aimed to investigate the association between single nucleotide polymorphisms (SNPs) in the gene of ADP-ribosylation factor-like 15 (ARL15) and morbidity of type 2 diabetes (T2D) in Yanbian Korean Chinese population. A total of 651 subjects including 327 subjects with T2D and 324 subjects with normal glucose tolerance (NGT) were involved. Genotypes and alleles of SNPs rs26770, rs4311394, and rs35941 in ARL15 were analyzed. The results indicated: (1) frequency of genotype GG for SNP rs26770 in T2D group was higher than that in NGT group and showing as recessive model (P = 0.045), (2) frequency of combined genotype AG-GG-CC of the three SNPs rs26770, rs4311394, and rs35941 in ARL15 in T2D group was higher than that in NGT group (P = 0.045), (3) Haplotype G A T for the three SNPs showed positive correlation with T2D development (P = 0.007). The following conclusion was drawn: for SNPs rs26770, rs4311394, and rs35941, genotype GG for rs26770, haplotype G A T, and joint genotype AG-GG-CC may be risk factors for T2D development in Korean Chinese population in Yanbian, China.