Top

Published in:

01-08-2020 | Subarachnoid Hemorrhage | Case Report

Intracranial hemorrhage complicating anticoagulant prophylactic therapy in three hospitalized COVID-19 patients

Authors: Muhammad Usman Ghani, Mukesh Kumar, Usman Ghani, Fnu Sonia, Syed Ali Abbas

Published in: Journal of NeuroVirology | Issue 4/2020

Abstract

SARS-CoV2 has led to a global pandemic affecting almost 3 million people in almost over 3 months. Various clinical presentations have been reported so far and no definite therapy is established. Anticoagulation is recommended by several experts to address the potential prothrombotic complications from COVID-19, but its safety and regimen need further clinical trials and safety and efficacy profile. Here, we present three cases of intracranial hemorrhage in three critically ill patients with COVID-19 and discuss their course in relation to various regimens of anticoagulation used.

Algahtani H, Subahi A, Shirah B (2016) Neurological complications of Middle East respiratory syndrome coronavirus: a report of two cases and review of the literature. Case Rep Neurol Med 2016:1–6

Al-Hameed FM (2017) Spontaneous intracranial hemorrhage in a patient with Middle East respiratory syndrome coronavirus. Saudi Medi J 38(2):196–200CrossRef

Desforges M, Le Coupanec A, Dubeau P, Bourgouin A, Lajoie L, Dubé M, Talbot PJ (2020) Human coronaviruses and other respiratory viruses: underestimated opportunistic pathogens of the central nervous system? Viruses 12(1):14CrossRef

Helms J, Tacquard C, Severac F, Leonard-Lorant I, Ohana M, Delabranche X, Merdji H, Clere-Jehl R, Schenck M, Fagot Gandet F, Fafi-Kremer S (2020) High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study. Intensive Care Med 4:1–0

Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, Chang J, Hong C, Zhou Y, Wang D, Miao X (2020) Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol 1;77(6):683–90

Tang N, Bai H, Chen X, Gong J, Li D, Sun Z (2020) Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. J Thromb Haemost 18(5):1094–1099CrossRef

Thachil J, Tang N, Gando S, Falanga A, Cattaneo M, Levi M, Clark C, Iba T (2020) ISTH interim guidance on recognition and management of coagulopathy in COVID-19. J Thromb Haemost 18(5):1023–1026CrossRef

Vu D, Ruggiero M, Choi WS, Masri D, Flyer M, Shyknevsky I, Stein EG (2020) Three unsuspected CT diagnoses of COVID-19. Emerg Radiol 13:1–4

Title: Intracranial hemorrhage complicating anticoagulant prophylactic therapy in three hospitalized COVID-19 patients
Authors: Muhammad Usman Ghani
Mukesh Kumar
Usman Ghani
Fnu Sonia
Syed Ali Abbas
Publication date: 01-08-2020
Publisher: Springer International Publishing
Keywords: Subarachnoid Hemorrhage
Computed Tomography
Computed Tomography
Brain Death
Anticoagulant
Subarachnoid Hemorrhage
COVID-19
Cerebral Edema
Published in: Journal of NeuroVirology / Issue 4/2020
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-020-00869-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Intracranial hemorrhage complicating anticoagulant prophylactic therapy in three hospitalized COVID-19 patients

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 4/2020

Comparison of tick-borne encephalitis between children and adults—analysis of 669 patients

Extracranial ectasia and embolic infarcts in HIV: two case reports and a clinical decision-making algorithm

West Nile virus neuroinvasive disease associated with rituximab therapy

Neurocognitive impairment and gray matter volume reduction in HIV-infected patients

Correction to: A candidate gene study of intermediate histopathological phenotypes in HIV-associated neurocognitive disorders

Miller Fisher syndrome diagnosis and treatment in a patient with SARS-CoV-2