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01-02-2020 | Herpes Virus | Case Report

Ventral striatal and septal area hypermetabolism on FDG-PET in herpes simplex viral encephalitis

Authors: T. Singhal, I. Solomon, F. Akbik, S. Smirnakis, H. Vaitkevicius

Published in: Journal of NeuroVirology | Issue 1/2020

Abstract

A 71-year-old man presented with sudden onset, generalized tonic-clonic seizures and altered mental status. Initial brain magnetic resonance imaging was normal but a brain FDG-PET scan showed hypermetabolism in the left ventral striatum and septal area. Initial cerebrospinal fluid (CSF) examination showed mildly elevated protein but herpes simplex virus (HSV) polymerase chain reaction (PCR) was negative. A repeat CSF examination performed 9 days later showed a positive HSV PCR. Histopathological and immunohistochemical examination of autopsy specimen confirmed the presence of CD45+ lymphocytes and HSV antigen, suggesting the presence of both inflammation and viral infection corresponding to PET abnormality.

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Title: Ventral striatal and septal area hypermetabolism on FDG-PET in herpes simplex viral encephalitis
Authors: T. Singhal
I. Solomon
F. Akbik
S. Smirnakis
H. Vaitkevicius
Publication date: 01-02-2020
Publisher: Springer International Publishing
Keywords: Herpes Virus
Magnetic Resonance Imaging
Magnetic Resonance Imaging
Autopsy
Polymerase Chain Reaction
Encephalitis
Herpes Simplex Encephalitis
Published in: Journal of NeuroVirology / Issue 1/2020
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-019-00779-2

ACC 2024 Congress

Springer Medicine

Ventral striatal and septal area hypermetabolism on FDG-PET in herpes simplex viral encephalitis

Abstract

ACC 2024 Congress

Springer Medicine

Abstract

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