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01-06-2019 | Alzheimer's Disease | Short Communication

Vitamin D is not associated with HIV-associated neurocognitive disorder in Rakai, Uganda

Authors: Deanna Saylor, Gertrude Nakigozi, Carlos A. Pardo, Alice Kisakye, Anupama Kumar, Noeline Nakasujja, Kevin R. Robertson, Ronald H. Gray, Maria J. Wawer, Ned Sacktor

Published in: Journal of NeuroVirology | Issue 3/2019

Abstract

We investigated whether vitamin D is associated with HIV-associated neurocognitive disorder (HAND). HIV-infected (HIV+) antiretroviral therapy (ART)-naïve adults in rural Uganda underwent a neurocognitive battery for determination of HAND stage at baseline and after 2 years. Baseline serum 25-hydroxyvitamin D (25OH-D) and serum and cerebrospinal fluids (CSF) vitamin D-binding protein (VDBP) were obtained. Of the 399 participants, 4% (n = 16) were vitamin D deficient (25OH-D < 20 ng/mL). There was no association between 25OH-D, serum or CSF VDBP, and HAND stage at baseline or follow-up. Future studies in a population with higher levels of vitamin D deficiency may be warranted.

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Title: Vitamin D is not associated with HIV-associated neurocognitive disorder in Rakai, Uganda
Authors: Deanna Saylor
Gertrude Nakigozi
Carlos A. Pardo
Alice Kisakye
Anupama Kumar
Noeline Nakasujja
Kevin R. Robertson
Ronald H. Gray
Maria J. Wawer
Ned Sacktor
Publication date: 01-06-2019
Publisher: Springer International Publishing
Keywords: Alzheimer's Disease
Human Immunodeficiency Virus
Vitamin D Deficiency
Alzheimer's Disease
HIV-Associated Dementia
HIV-Associated Dementia
Published in: Journal of NeuroVirology / Issue 3/2019
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-018-00719-6

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Vitamin D is not associated with HIV-associated neurocognitive disorder in Rakai, Uganda

Abstract

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Abstract

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