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Journal of NeuroVirology
Published in: Journal of NeuroVirology 2/2018

01-04-2018 | Review

Doxycycline-inducible and astrocyte-specific HIV-1 Tat transgenic mice (iTat) as an HIV/neuroAIDS model

Authors: Dianne Langford, Byung oh Kim, Wei Zou, Yan Fan, Pejman Rahimain, Ying Liu, Johnny J. He

Published in: Journal of NeuroVirology | Issue 2/2018

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Abstract

HIV-1 Tat is known to be neurotoxic and important for HIV/neuroAIDS pathogenesis. However, the overwhelming majority of the studies involved use of recombinant Tat protein. To understand the contributions of Tat protein to HIV/neuroAIDS and the underlying molecular mechanisms of HIV-1 Tat neurotoxicity in the context of a whole organism and independently of HIV-1 infection, a doxycycline-inducible astrocyte-specific HIV-1 Tat transgenic mouse (iTat) was created. Tat expression in the brains of iTat mice was determined to be in the range of 1–5 ng/ml and led to astrocytosis, loss of neuronal dendrites, and neuroinflammation. iTat mice have allowed us to define the direct effects of Tat on astrocytes and the molecular mechanisms of Tat-induced GFAP expression/astrocytosis, astrocyte-mediated Tat neurotoxicity, Tat-impaired neurogenesis, Tat-induced loss of neuronal integrity, and exosome-associated Tat release and uptake. In this review, we will provide an overview about the creation and characterization of this model and its utilities for our understanding of Tat neurotoxicity and the underlying molecular mechanisms.
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Metadata
Title
Doxycycline-inducible and astrocyte-specific HIV-1 Tat transgenic mice (iTat) as an HIV/neuroAIDS model
Authors
Dianne Langford
Byung oh Kim
Wei Zou
Yan Fan
Pejman Rahimain
Ying Liu
Johnny J. He
Publication date
01-04-2018
Publisher
Springer International Publishing
Published in
Journal of NeuroVirology / Issue 2/2018
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI
https://doi.org/10.1007/s13365-017-0598-9

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