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Published in:

01-02-2017

Human cytomegalovirus downregulates SLITRK6 expression through IE2

Authors: Huanan Liao, Haruna Sato, Ryosuke Chiba, Tomoko Kawai, Kazuhiko Nakabayashi, Kenichiro Hata, Hidenori Akutsu, Shigeyoshi Fujiwara, Hiroyuki Nakamura

Published in: Journal of NeuroVirology | Issue 1/2017

Abstract

Congenital human cytomegalovirus (HCMV) infection causes sensorineural hearing loss (SNHL) and other neurological disorders, although the neuropathogenesis of HCMV infection is not well understood. Here, we show that the expression of SLITRK6, one of causative genes for hereditary SNHL, was robustly downregulated by HCMV infection in cultured neural cells. We also show that HCMV-encoded immediate-early 2 (IE2) proteins mediate this downregulation and their carboxy-terminal region, especially amino acid residue Gln⁵⁴⁸, has a critical role. These findings suggest that the downregulation of SLITRK6 expression by IE2 may have a role in HCMV-induced SNHL and other neurological disorders.

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Title: Human cytomegalovirus downregulates SLITRK6 expression through IE2
Authors: Huanan Liao
Haruna Sato
Ryosuke Chiba
Tomoko Kawai
Kazuhiko Nakabayashi
Kenichiro Hata
Hidenori Akutsu
Shigeyoshi Fujiwara
Hiroyuki Nakamura
Publication date: 01-02-2017
Publisher: Springer International Publishing
Published in: Journal of NeuroVirology / Issue 1/2017
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-016-0475-y

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Human cytomegalovirus downregulates SLITRK6 expression through IE2

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