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01-02-2017 | Short Communication

HIV and decreased risk of multiple sclerosis: role of low CD4+ lymphocyte count and male prevalence

Authors: Tatiana Koudriavtseva, Domenico Plantone, Chiara Mandoj, Diana Giannarelli, Alessandra Latini, Manuela Colafigli, Elisabetta Trento, Paola Cordiali-Fei, Fulvia Pimpinelli

Published in: Journal of NeuroVirology | Issue 1/2017

Abstract

In this retrospective case-control study, we compared the number of circulating lymphocyte subsets among 31 healthy controls, 18 naïve and 40 antiretroviral-treated HIV patients, 28 untreated and 18 treated relapsing-remitting multiple sclerosis (MS) patients. Lymphocyte subsets were no different between untreated MS patients and controls. Untreated and treated MS had a lower CD8+ count and a higher CD4+ number compared to untreated and treated HIV patients except similar CD4+ number between treated MS and HIV patients. CD4/CD8 ratio was lower in female HIV non-responders and in relapsing MS women compared, respectively, to female HIV responders and remitting MS women, and there were no differences in men.

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Title: HIV and decreased risk of multiple sclerosis: role of low CD4+ lymphocyte count and male prevalence
Authors: Tatiana Koudriavtseva
Domenico Plantone
Chiara Mandoj
Diana Giannarelli
Alessandra Latini
Manuela Colafigli
Elisabetta Trento
Paola Cordiali-Fei
Fulvia Pimpinelli
Publication date: 01-02-2017
Publisher: Springer International Publishing
Published in: Journal of NeuroVirology / Issue 1/2017
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-016-0471-2

At a glance: The STEP trials

Springer Medicine

HIV and decreased risk of multiple sclerosis: role of low CD4+ lymphocyte count and male prevalence

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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