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01-12-2016

Suicide risk and prevalence of major depressive disorder (MDD) among individuals infected with HIV-1 subtype C versus B in Southern Brazil

Authors: Sergio Monteiro de Almeida, Francisco Jaime Barbosa, Rujvi Kamat, Ana Paula de Pereira, Sonia Mara Raboni, Indianara Rotta, Clea Elisa Ribeiro, Mariana Cherner, Ronald J. Ellis, Joseph Hampton Atkinson, HNRC Group

Published in: Journal of NeuroVirology | Issue 6/2016

Abstract

Major depressive disorder (MDD) is among the most prevalent neuropsychiatric disorders associated with HIV infection; however, its risks and neurobiologic correlates in diverse cultures are poorly understood. This study aimed to examine the frequency of MDD among HIV+ participants in southern Brazil. We hypothesized that the frequency and severity of MDD would be higher among individuals with HIV+ compared with HIV− and higher in HIV subtype B compared with C. Individuals with HIV (n = 39) as well as seronegative controls (n = 22) were enrolled in a cross-sectional, prospective, observational study. Current and lifetime history of MDD was diagnosed by MINI-Plus; symptom severity was assessed by Beck Depression Inventory-II (BDI-II). Current and past episodes of MDD were significantly more frequent in the HIV+ versus HIV− group: current MDD, 15 (38.5 %) vs. 0 (0 %), p = 0.0004; past MDD, 24 (61.5 %) vs. 3 (13.6 %), p = 0.0004. The median BDI-II score in the HIV+ group was significantly higher than that in the HIV− (13 (8–27.5) vs. 2.5 (1–5.5); p < 0.0001). Current suicide risk, defined as during the last month, was found in 18 % of participants in the HIV-positive and none in the HIV-negative group. Neither current MDD frequency (8 (57.1 %) vs. 6 (40 %), p = 0.47) nor BDI-II score differed across subtypes B and C. HIV+ group may be more likely to experience current MDD than HIV−. This was the first study to compare the frequency and severity of MDD in HIV subtypes B and C; we found no difference between HIV subtypes B and C.

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Title: Suicide risk and prevalence of major depressive disorder (MDD) among individuals infected with HIV-1 subtype C versus B in Southern Brazil
Authors: Sergio Monteiro de Almeida
Francisco Jaime Barbosa
Rujvi Kamat
Ana Paula de Pereira
Sonia Mara Raboni
Indianara Rotta
Clea Elisa Ribeiro
Mariana Cherner
Ronald J. Ellis
Joseph Hampton Atkinson
HNRC Group
Publication date: 01-12-2016
Publisher: Springer International Publishing
Published in: Journal of NeuroVirology / Issue 6/2016
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-016-0454-3

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Suicide risk and prevalence of major depressive disorder (MDD) among individuals infected with HIV-1 subtype C versus B in Southern Brazil

Abstract

Keynote webinar | Spotlight on sleep in brain health

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Abstract

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