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01-12-2013

Neurocognitive impairment in HIV-1 clade C- versus B-infected individuals in Southern Brazil

Authors: Sergio Monteiro de Almeida, Clea Elisa Ribeiro, Ana Paula de Pereira, Jayraan Badiee, Mariana Cherner, Davey Smith, Ingrid Maich, Sonia Mara Raboni, Indianara Rotta, Francisco Jaime Barbosa, Robert K. Heaton, Anya Umlauf, Ronald J. Ellis

Published in: Journal of NeuroVirology | Issue 6/2013

Abstract

HIV-1 clade C isolates show reduced Tat protein chemoattractant activity compared with clade B. This might influence neuropathogenesis by altering trafficking of monocytes into the CNS. A previous study suggested low rates of HIV-associated dementia in clade C-infected individuals. The present study evaluated neurocognitive impairment rates in clade B- and C-infected individuals from the same local population. HIV+ and HIV− participants were recruited from the same geographic region in Southern Brazil. We evaluated neuropsychological (NP) impairment using a screening instrument (the International HIV Dementia Scale (IHDS)), as well as a Brazilian Portuguese adaptation of a comprehensive battery that has demonstrated sensitivity to HIV-associated neurocognitive disorders (HAND) internationally. NP performance in controls was used to generate T scores and impairment ratings by the global deficit score (GDS) method. Clade assignments were ascertained by sequencing pol and env. Blood and cerebrospinal fluid were collected from all HIV+ participants. HIV+ and HIV− participants were comparable on demographic characteristics. HIV+ participants overall were more likely to be impaired than HIV− by the IHDS and the GDS. Clade B- and C-infected individuals were demographically similar and did not differ significantly in rates of impairment. The prevalence of pleocytosis, a marker of intrathecal cellular chemotaxis, also did not differ between clade B and C infections. Clade B and C HIV-infected individuals from the same geographic region, when ascertained using comparable methods, did not differ in their rates of neurocognitive impairment, and there was no evidence of differences in CNS chemotaxis.

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Title: Neurocognitive impairment in HIV-1 clade C- versus B-infected individuals in Southern Brazil
Authors: Sergio Monteiro de Almeida
Clea Elisa Ribeiro
Ana Paula de Pereira
Jayraan Badiee
Mariana Cherner
Davey Smith
Ingrid Maich
Sonia Mara Raboni
Indianara Rotta
Francisco Jaime Barbosa
Robert K. Heaton
Anya Umlauf
Ronald J. Ellis
Publication date: 01-12-2013
Publisher: Springer US
Published in: Journal of NeuroVirology / Issue 6/2013
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-013-0215-5

At a glance: The STEP trials

Springer Medicine

Neurocognitive impairment in HIV-1 clade C- versus B-infected individuals in Southern Brazil

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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