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01-04-2011 | Brief Communication

Viral genome silencing by neuronal sirtuin 1

Authors: Kelly E. Picchione, Arin Bhattacharjee

Published in: Journal of NeuroVirology | Issue 2/2011

Abstract

Neurotropic viruses remain dormant in sensory neurons for years, but upon reactivation, they can produce multiple disease states including pain symptoms. Latent viral DNA is extrachromosomal, maintained as a circular episome bound to histones. Here, we show the regulation of an adenoviral genome by the nicotinamide adenine dinucleotide (NAD⁺)-dependent histone deacetylator Sirt1 in dorsal root ganglion neurons. Pharmacological modulation of Sirt1 and Sirt1 overexpression both affected viral transgene expression. We propose that age or stress-related neuronal NAD⁺ depletion may be a trigger for viral reactivation.

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Title: Viral genome silencing by neuronal sirtuin 1
Authors: Kelly E. Picchione
Arin Bhattacharjee
Publication date: 01-04-2011
Publisher: Springer US
Published in: Journal of NeuroVirology / Issue 2/2011
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-010-0012-3

At a glance: The STEP trials

Springer Medicine

Viral genome silencing by neuronal sirtuin 1

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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