Published in:
01-04-2011
Marked relationship between matrix metalloproteinase 7 and brain atrophy in HIV infection
Authors:
Ann B. Ragin, Ying Wu, Renee Ochs, Hongyan Du, Leon G. Epstein, Katherine Conant, Justin C. McArthur
Published in:
Journal of NeuroVirology
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Issue 2/2011
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Abstract
Circulating levels of matrix metalloproteinases (MMP-1 and 7) have been found to correlate with the severity of brain injury in HIV-infected subjects. This study used high-resolution neuroanatomic imaging and automated segmentation algorithms to clarify this relationship. Both metalloproteinases were significantly correlated with increased cerebrospinal fluid volume fraction. Comprehensive brain volumetric analysis revealed a more marked relationship with atrophy for MMP-7, which was significantly correlated with neural injury in multiple brain regions and nearly all ventricular measurements. MMP-7 was also correlated with measures of virologic and cognitive status.