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01-06-2016 | Review Article

Is zinc an intra-islet regulator of glucagon secretion?

Authors: Hisamitsu Ishihara, Claes B. Wollheim

Published in: Diabetology International | Issue 2/2016

Abstract

More than a decade ago, zinc was suggested to have a role as an intra-islet regulator of glucagon secretion. Several lines of experimental evidence have since provided support for this hypothesis, though contradictory observations have also been reported. Meanwhile, Slc30A/ZnT8, a zinc transporter expressed in insulin and glucagon secretory granules, was identified. Furthermore, genome wide association analyses revealed it to be a candidate causative gene for type 2 diabetes mellitus. Recent progress in gene manipulation in animals yielded considerable information on the role of zinc in islet cells. In this mini-review, data pertaining the roles played by zinc in islet hormone secretion are summarized and discussed.

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Title: Is zinc an intra-islet regulator of glucagon secretion?
Authors: Hisamitsu Ishihara
Claes B. Wollheim
Publication date: 01-06-2016
Publisher: Springer Japan
Published in: Diabetology International / Issue 2/2016
Print ISSN: 2190-1678
Electronic ISSN: 2190-1686
DOI: https://doi.org/10.1007/s13340-016-0259-x

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