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01-05-2009 | Original Article

Comprehensive analysis of microRNA expression patterns in renal biopsies of lupus nephritis patients

Authors: Yong Dai, Weiguo Sui, Huijuan Lan, Qiang Yan, He Huang, YuanShuai Huang

Published in: Rheumatology International | Issue 7/2009

Abstract

MicroRNAs (miRNAs) are noncoding RNA molecules of 21–24 nt that regulate the expression of target genes in a post-transcriptional manner. Evidence indicates that miRNAs play essential roles in embryogenesis, cell differentiation, and pathogenesis of human diseases. This study describes a comparison between the miRNA profile of kidney biopsies from lupus nephritis (LN) patients and the controls, to develop further understanding of the pathogenesis of LN. Kidney biopsies were taken from five LN patients detected LN Class II and three normal controls. The miRNA microarray chip analysis identified 66 miRNAs differentially expressed in LN. The chip results were confirmed by QRT-PCR. This work indicates that miRNAs are potential diagnosis biomarkers and probable factors involved in the pathogenesis of LN.

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Title: Comprehensive analysis of microRNA expression patterns in renal biopsies of lupus nephritis patients
Authors: Yong Dai
Weiguo Sui
Huijuan Lan
Qiang Yan
He Huang
YuanShuai Huang
Publication date: 01-05-2009
Publisher: Springer-Verlag
Published in: Rheumatology International / Issue 7/2009
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-008-0758-6

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