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Nuclear Medicine and Molecular Imaging
Published in: Nuclear Medicine and Molecular Imaging 4/2016

01-12-2016 | Interesting Image

Systemic Immune Response to Vaccination on FDG-PET/CT

Authors: Mark Mingos, Stephanie Howard, Nicholas Giacalone, David Kozono, Heather Jacene

Published in: Nuclear Medicine and Molecular Imaging | Issue 4/2016

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Abstract

A patient with newly diagnosed right lung cancer had transient 18F-fluorodeoxyglucose (FDG)-avid left axillary lymph nodes and intense splenic FDG uptake on positron emission tomography (PET)/computed tomography (CT). History revealed that the patient received a left-sided influenza vaccine 2–3 days before the examination. Although inflammatory FDG uptake in ipsilateral axillary nodes is reported, to our knowledge, this is the first report of visualization of the systemic immune response in the spleen related to the influenza vaccination on FDG-PET/CT. The history, splenic uptake and time course on serial FDG-PET/CT helped to avoid a false-positive interpretation for progressing lung cancer and alteration of the radiation therapy plan.
Literature
1.
Panagiotidis E, Exarhos D, Housianakou I, et al. FDG uptake in axillary lymph nodes after vaccination against pandemic (H1N1). Eur Radiol. 2010;20:1251–3.CrossRefPubMed
2.
Shirone N, Shinkai T, Yamane T, et al. Axillary lymph node accumulation on FDG-PET/CT after influenza vaccination. Ann Nucl Med. 2012;26:248–52.CrossRefPubMed
3.
Thomassen A, Lerberg Nielsen A, Gerke O, et al. Duration of 18 F-FDG avidity in lymph nodes after pandemic H1N1v and seasonal influenza vaccination. Eur J Nucl Med Mol Imaging. 2011;38:894–8.CrossRefPubMed
4.
Williams G, Joyce RM, Parker JA. False-positive axillary lymph node on FDG-PET/CT scan resulting from immunization. Clin Nucl Med. 2006;31:731–2.CrossRefPubMed
5.
Nam HY, Kim SJ, Kim IJ, et al. The clinical implication and prediction of diffuse splenic FDG uptake during cancer surveillance. Clin Nucl Med. 2010;35:759–63.CrossRefPubMed
6.
Salaun PY, Gastinne T, Bodet-Milin C, et al. Analysis of 18 F-FDG PET diffuse bone marrow uptake and splenic uptake in staging of Hodgkin’s lymphoma: a reflection of disease infiltration or just inflammation? Eur J Nucl Med Mol Imaging. 2009;36:1813–21.CrossRefPubMed
7.
Basu S, Baghel NS. Intense FDG uptake in the spleen due to recent granulocyte-macrophage colony-stimulating factor administration: follow-up scan clarifying the situation. J Cancer Res Ther. 2011;7:228–9.CrossRefPubMed
8.
Jacene HA, Ishimori T, Engles JM, et al. Effects of pegfilgrastim on normal biodistribution of 18 F-FDG: preclinical and clinical studies. J Nucl Med. 2006;47:950–6.PubMed
9.
Liu Y. Clinical significance of diffusely increased splenic uptake on FDG-PET. Nucl Med Commun. 2009;30:763–9.CrossRefPubMed
10.
Sugawara Y, Zasadny KR, Kison PV, et al. Splenic fluorodeoxyglucose uptake increased by granulocyte colony-stimulating factor therapy: PET imaging results. J Nucl Med. 1999;40:1456–62.PubMed
11.
Jacene HA, Stearns V, Wahl RL. Lymphadenopathy resulting from acute hepatitis C infection mimicking metastatic breast carcinoma on FDG PET/CT. Clin Nucl Med. 2006;31:379–81.CrossRefPubMed
12.
Thomas DL, Syrbu S, Graham MM. Epstein-Barr virus mimicking lymphoma on FDG-PET/CT. Clin Nucl Med. 2009;34:891–3.CrossRefPubMed
13.
Balink H, Nabers H, Kibbelaar RE. High F-18 FDG uptake in bone marrow by cytokines secreting ectopic mucoepidermoid carcinoma. Clin Nucl Med. 2009;34:823–4.CrossRefPubMed
14.
Morooka M, Kubota K, Murata Y, et al. (18)F-FDG-PET/CT findings of granulocyte colony stimulating factor (G-CSF)-producing lung tumors. Ann Nucl Med. 2008;22:635–9.CrossRefPubMed
Metadata
Title
Systemic Immune Response to Vaccination on FDG-PET/CT
Authors
Mark Mingos
Stephanie Howard
Nicholas Giacalone
David Kozono
Heather Jacene
Publication date
01-12-2016
Publisher
Springer Berlin Heidelberg
Published in
Nuclear Medicine and Molecular Imaging / Issue 4/2016
Print ISSN: 1869-3474
Electronic ISSN: 1869-3482
DOI
https://doi.org/10.1007/s13139-015-0385-6

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