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European Radiology
Published in: European Radiology 5/2010

01-05-2010 | Nuclear Medicine

FDG uptake in axillary lymph nodes after vaccination against pandemic (H1N1)

Authors: Emmanouil Panagiotidis, Demetrios Exarhos, Irene Housianakou, Apostolos Bournazos, Ioannis Datseris

Published in: European Radiology | Issue 5/2010

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Abstract

Objective

To alert the imaging community to potential false positive findings related to current immunization programmes against H1N1 influenza virus.

Methods

We reviewed 10 patients referred for positron emission tomography/computed tomography (PET/CT) who had undergone recent vaccination.

Results

All studies showed 18F-fluorodeoxyglucose (FDG) uptake in the draining axillary lymph nodes close to the vaccination site, while low-dose CT revealed lymph nodes ranged between 0.5 cm and 1.2 cm at the same site.

Conclusion

This potential pitfall in PET/CT should be borne in mind during current vaccination programmes.
Literature
1.
New influenza A/H1N1 virus: global epidemiological situation (2009) Wkly Epidemiol Rec 84:249–257
2.
Ahmed R, Gray D (1996) Immunological memory and protective immunity: understanding their relation. Science 272:54–60CrossRefPubMed
3.
Iyengar S, Chin B, Margolick JB et al (2003) Anatomical loci of HIV-associated immune activation and association with viraemia. Lancet 362:945–950CrossRefPubMed
4.
Williams G, Joyce RM, Parker JA (2006) False-positive axillary lymph node on FDG-PET/CT scan resulting from immunization. Clin Nucl Med 31:731–732CrossRefPubMed
Metadata
Title
FDG uptake in axillary lymph nodes after vaccination against pandemic (H1N1)
Authors
Emmanouil Panagiotidis
Demetrios Exarhos
Irene Housianakou
Apostolos Bournazos
Ioannis Datseris
Publication date
01-05-2010
Publisher
Springer-Verlag
Published in
European Radiology / Issue 5/2010
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-010-1719-5

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