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Published in: Translational Stroke Research 3/2017

01-06-2017 | Commentary

Can Quality Improvement Tools Overcome the Translational Roadblock—the Vital Influence of the Researcher

Author: Serge Marbacher

Published in: Translational Stroke Research | Issue 3/2017

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Excerpt

Both special issues “Challenges and Controversies in Translational Stroke Research, Part 1 and 2” provide an excellent overview of the methodological challenges encountered in the various stages of planning, implementation, and evaluation of preclinical stroke studies. The topics discussed do not apply solely to the field of stroke research, but to many other fields of translational science as well. This collection of articles by highly informed scientists clearly illustrates that a multitude of approaches and measures is needed to address bias in preclinical research in order to increase the translation of knowledge from basic science to clinical practice. …
Literature
1.
go back to reference Boltze J, Wagner DC, Henninger N, Plesnila N, Ayata C. Phase iii preclinical trials in translational stroke research: community response on framework and guidelines. Transl Stroke Res. 2016;7:241–7.CrossRefPubMedPubMedCentral Boltze J, Wagner DC, Henninger N, Plesnila N, Ayata C. Phase iii preclinical trials in translational stroke research: community response on framework and guidelines. Transl Stroke Res. 2016;7:241–7.CrossRefPubMedPubMedCentral
2.
go back to reference Ahnstedt H, McCullough LD, Cipolla MJ. The importance of considering sex differences in translational stroke research. Transl Stroke Res. 2016;7:261–73.CrossRefPubMed Ahnstedt H, McCullough LD, Cipolla MJ. The importance of considering sex differences in translational stroke research. Transl Stroke Res. 2016;7:261–73.CrossRefPubMed
3.
go back to reference Becker KJ. Strain-related differences in the immune response: relevance to human stroke. Transl Stroke Res. 2016;7:303–12.CrossRefPubMed Becker KJ. Strain-related differences in the immune response: relevance to human stroke. Transl Stroke Res. 2016;7:303–12.CrossRefPubMed
4.
go back to reference Kent TA, Mandava P. Embracing biological and methodological variance in a new approach to pre-clinical stroke testing. Transl Stroke Res. 2016;7:274–83.CrossRefPubMed Kent TA, Mandava P. Embracing biological and methodological variance in a new approach to pre-clinical stroke testing. Transl Stroke Res. 2016;7:274–83.CrossRefPubMed
5.
go back to reference Ergul A, Hafez S, Fouda A, Fagan SC. Impact of comorbidities on acute injury and recovery in preclinical stroke research: focus on hypertension and diabetes. Transl Stroke Res. 2016;7:248–60.CrossRefPubMed Ergul A, Hafez S, Fouda A, Fagan SC. Impact of comorbidities on acute injury and recovery in preclinical stroke research: focus on hypertension and diabetes. Transl Stroke Res. 2016;7:248–60.CrossRefPubMed
6.
go back to reference Hoffmann U, Sheng H, Ayata C, Warner DS. Anesthesia in experimental stroke research. Transl Stroke Res. 2016;7:358–67.CrossRefPubMed Hoffmann U, Sheng H, Ayata C, Warner DS. Anesthesia in experimental stroke research. Transl Stroke Res. 2016;7:358–67.CrossRefPubMed
7.
go back to reference Hommel M, Detante O, Favre I, Touze E, Jaillard A. How to measure recovery? Revisiting concepts and methods for stroke studies. Transl Stroke Res. 2016;7:388–94.CrossRefPubMed Hommel M, Detante O, Favre I, Touze E, Jaillard A. How to measure recovery? Revisiting concepts and methods for stroke studies. Transl Stroke Res. 2016;7:388–94.CrossRefPubMed
9.
go back to reference Jolkkonen J, Kwakkel G. Translational hurdles in stroke recovery studies. Transl Stroke Res. 2016;7:331–42.CrossRefPubMed Jolkkonen J, Kwakkel G. Translational hurdles in stroke recovery studies. Transl Stroke Res. 2016;7:331–42.CrossRefPubMed
10.
go back to reference Richter SH, Garner JP, Wurbel H. Environmental standardization: cure or cause of poor reproducibility in animal experiments? Nat Methods. 2009;6:257–61.CrossRefPubMed Richter SH, Garner JP, Wurbel H. Environmental standardization: cure or cause of poor reproducibility in animal experiments? Nat Methods. 2009;6:257–61.CrossRefPubMed
11.
go back to reference Baker D, Lidster K, Sottomayor A, Amor S. Two years later: journals are not yet enforcing the arrive guidelines on reporting standards for pre-clinical animal studies. PLoS Biol. 2014;12:e1001756.CrossRefPubMedPubMedCentral Baker D, Lidster K, Sottomayor A, Amor S. Two years later: journals are not yet enforcing the arrive guidelines on reporting standards for pre-clinical animal studies. PLoS Biol. 2014;12:e1001756.CrossRefPubMedPubMedCentral
12.
go back to reference Reichlin TS, Vogt L, Wurbel H. The researchers’ view of scientific rigor-survey on the conduct and reporting of in vivo research. PLoS One. 2016;11:e0165999.CrossRefPubMedPubMedCentral Reichlin TS, Vogt L, Wurbel H. The researchers’ view of scientific rigor-survey on the conduct and reporting of in vivo research. PLoS One. 2016;11:e0165999.CrossRefPubMedPubMedCentral
13.
go back to reference Stroke Therapy Academic Industry R. Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke. 1999;30:2752–8.CrossRef Stroke Therapy Academic Industry R. Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke. 1999;30:2752–8.CrossRef
14.
go back to reference Saver JL, Albers GW, Dunn B, Johnston KC, Fisher M, Consortium SV. Stroke therapy academic industry roundtable (stair) recommendations for extended window acute stroke therapy trials. Stroke. 2009;40:2594–600.CrossRefPubMedPubMedCentral Saver JL, Albers GW, Dunn B, Johnston KC, Fisher M, Consortium SV. Stroke therapy academic industry roundtable (stair) recommendations for extended window acute stroke therapy trials. Stroke. 2009;40:2594–600.CrossRefPubMedPubMedCentral
15.
go back to reference Stem Cell Therapies as an Emerging Paradigm in Stroke P. Stem cell therapies as an emerging paradigm in stroke (steps): bridging basic and clinical science for cellular and neurogenic factor therapy in treating stroke. Stroke. 2009;40:510–5.CrossRef Stem Cell Therapies as an Emerging Paradigm in Stroke P. Stem cell therapies as an emerging paradigm in stroke (steps): bridging basic and clinical science for cellular and neurogenic factor therapy in treating stroke. Stroke. 2009;40:510–5.CrossRef
16.
go back to reference Savitz SI, Chopp M, Deans R, Carmichael T, Phinney D, Wechsler L, et al. Stem cell therapy as an emerging paradigm for stroke (steps) ii. Stroke. 2011;42:825–9.CrossRefPubMed Savitz SI, Chopp M, Deans R, Carmichael T, Phinney D, Wechsler L, et al. Stem cell therapy as an emerging paradigm for stroke (steps) ii. Stroke. 2011;42:825–9.CrossRefPubMed
17.
go back to reference Lapchak PA, Zhang JH, Noble-Haeusslein LJ. Rigor guidelines: escalating stair and steps for effective translational research. Transl Stroke Res. 2013;4:279–85.CrossRefPubMed Lapchak PA, Zhang JH, Noble-Haeusslein LJ. Rigor guidelines: escalating stair and steps for effective translational research. Transl Stroke Res. 2013;4:279–85.CrossRefPubMed
19.
go back to reference Smith MM, Clarke EC, Little CB. Considerations for the design and execution of protocols for animal research and treatment to improve reproducibility and standardization: “Depart well-prepared and arrive safely”. Osteoarthritis Cartilage. 2016. Smith MM, Clarke EC, Little CB. Considerations for the design and execution of protocols for animal research and treatment to improve reproducibility and standardization: “Depart well-prepared and arrive safely”. Osteoarthritis Cartilage. 2016.
20.
go back to reference Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving bioscience research reporting: the arrive guidelines for reporting animal research. PLoS Biol. 2010;8:e1000412.CrossRefPubMedPubMedCentral Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. Improving bioscience research reporting: the arrive guidelines for reporting animal research. PLoS Biol. 2010;8:e1000412.CrossRefPubMedPubMedCentral
21.
go back to reference Hooijmans CR, Leenaars M, Ritskes-Hoitinga M. A gold standard publication checklist to improve the quality of animal studies, to fully integrate the three rs, and to make systematic reviews more feasible. Altern Lab Anim. 2010;38:167–82.PubMed Hooijmans CR, Leenaars M, Ritskes-Hoitinga M. A gold standard publication checklist to improve the quality of animal studies, to fully integrate the three rs, and to make systematic reviews more feasible. Altern Lab Anim. 2010;38:167–82.PubMed
22.
go back to reference Dirnagl U, Fisher M. International, multicenter randomized preclinical trials in translational stroke research: it’s time to act. J Cereb Blood Flow Metab. 2012;32:933–5.CrossRefPubMedPubMedCentral Dirnagl U, Fisher M. International, multicenter randomized preclinical trials in translational stroke research: it’s time to act. J Cereb Blood Flow Metab. 2012;32:933–5.CrossRefPubMedPubMedCentral
23.
go back to reference Bath PM, Macleod MR, Green AR. Emulating multicentre clinical stroke trials: a new paradigm for studying novel interventions in experimental models of stroke. Int J Stroke. 2009;4:471–9.CrossRefPubMed Bath PM, Macleod MR, Green AR. Emulating multicentre clinical stroke trials: a new paradigm for studying novel interventions in experimental models of stroke. Int J Stroke. 2009;4:471–9.CrossRefPubMed
Metadata
Title
Can Quality Improvement Tools Overcome the Translational Roadblock—the Vital Influence of the Researcher
Author
Serge Marbacher
Publication date
01-06-2017
Publisher
Springer US
Published in
Translational Stroke Research / Issue 3/2017
Print ISSN: 1868-4483
Electronic ISSN: 1868-601X
DOI
https://doi.org/10.1007/s12975-017-0524-8

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