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Translational Stroke Research
Published in: Translational Stroke Research 4/2016

01-08-2016 | SI: Challenges and Controversies in Translational Stroke Research

Strain-Related Differences in the Immune Response: Relevance to Human Stroke

Author: Kyra J. Becker

Published in: Translational Stroke Research | Issue 4/2016

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Abstract

There are significant differences in the immune response and in the susceptibility to autoimmune diseases among rodent strains. It would thus be expected that the contribution of the immune response to cerebral ischemic injury would also differ among rodent strains. More importantly, there are significant differences between the immune responses of rodents and humans. All of these factors are likely to impact the successful translation of immunomodulatory therapies from experimental rodent models to patients with stroke.
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Metadata
Title
Strain-Related Differences in the Immune Response: Relevance to Human Stroke
Author
Kyra J. Becker
Publication date
01-08-2016
Publisher
Springer US
Published in
Translational Stroke Research / Issue 4/2016
Print ISSN: 1868-4483
Electronic ISSN: 1868-601X
DOI
https://doi.org/10.1007/s12975-016-0455-9

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