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Translational Stroke Research
Published in: Translational Stroke Research 6/2016

01-12-2016 | Commentary

Intraventricular Hemorrhage: the Role of Blood Components in Secondary Injury and Hydrocephalus

Authors: Thomas Garton, Richard F. Keep, D. Andrew Wilkinson, Jennifer M. Strahle, Ya Hua, Hugh J. L. Garton, Guohua Xi

Published in: Translational Stroke Research | Issue 6/2016

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Excerpt

Intraventricular hemorrhage (IVH) is characterized by an influx of blood into the ventricles of the brain. It has a highly morbid prognosis and develops in more than 12,000 premature infants every year in the USA [1, 2]. Within the last two decades, about 31 % of successfully resuscitated very preterm infants—born prior to 30-week gestational age—experienced IVH, one third of which were of grade 3 or 4 severity [3]. Furthermore, the incidence of severe IVH has increased over the last 20 years. In addition to the severe neurological deficits associated with the disease, high-grade IVH can lead to post-hemorrhagic hydrocephalus (PHH), with 48 % of patients sustaining grades 3 and 4 IVH developing PHH. When combined, IVH-PHH is a dauntingly critical condition, and one whose pathology is not completely understood. …
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Metadata
Title
Intraventricular Hemorrhage: the Role of Blood Components in Secondary Injury and Hydrocephalus
Authors
Thomas Garton
Richard F. Keep
D. Andrew Wilkinson
Jennifer M. Strahle
Ya Hua
Hugh J. L. Garton
Guohua Xi
Publication date
01-12-2016
Publisher
Springer US
Published in
Translational Stroke Research / Issue 6/2016
Print ISSN: 1868-4483
Electronic ISSN: 1868-601X
DOI
https://doi.org/10.1007/s12975-016-0480-8

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