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Cardiovascular Intervention and Therapeutics
Published in: Cardiovascular Intervention and Therapeutics 1/2015

01-01-2015 | Review Article

Histopathology of vascular response to drug-eluting stents: an insight from human autopsy into daily practice

Authors: Masataka Nakano, Renu Virmani

Published in: Cardiovascular Intervention and Therapeutics | Issue 1/2015

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Abstract

Drug-eluting stents (DES) were developed with the primary purpose of inhibiting neointimal overgrowth following percutaneous coronary intervention (PCI). While DES have significantly reduced the rates of restenosis compared with bare metal stent (BMS), they have not completely eliminated it. Moreover, late stent thrombosis (LST), attributed to delayed arterial healing or abnormal vessel responses to DES, have emerged as a major safety concern. Although newer DES or other novel devices are expected to show promising results, the problems in interventional technologies have not been completely resolved. In this review, we will consider the current status of DES in clinical practice and discuss the strengths and limitations of recent advances from the view of histopathology.
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Metadata
Title
Histopathology of vascular response to drug-eluting stents: an insight from human autopsy into daily practice
Authors
Masataka Nakano
Renu Virmani
Publication date
01-01-2015
Publisher
Springer Japan
Published in
Cardiovascular Intervention and Therapeutics / Issue 1/2015
Print ISSN: 1868-4300
Electronic ISSN: 1868-4297
DOI
https://doi.org/10.1007/s12928-014-0281-5

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