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Current Breast Cancer Reports

Published in:

01-03-2018 | Psycho-Oncology and Supportive Care (E Shinn and C Fagundes, Section Editors)

Obesity, Dietary Factors, Nutrition, and Breast Cancer Risk

Authors: Annina Seiler, Michelle A. Chen, Ryan L. Brown, Christopher P. Fagundes

Published in: Current Breast Cancer Reports | Issue 1/2018

Abstract

Purpose of Review

To synthesize the critical role of obesity-associated inflammation, dietary factors, and nutrition in determining breast cancer risk.

Recent Findings

Obesity-associated inflammation is strongly linked to breast cancer risk and progression, largely via two processes: inflammatory pathways and dysregulated metabolism. Cytokine production in excess adipose tissues creates a chronic inflammatory microenvironment, which favors tumor development. Lifestyle factors, including diet, have long been recognized as important determinants of breast cancer risk and mortality.

Summary

Obesity increases the risk of developing breast cancer in both pre- and postmenopausal women and also negatively affects breast cancer recurrence and survival. Poor dietary habits characterized by the high intake of refined starches, sugar, and both saturated and trans-saturated fats, as well as the low intake of omega-3 fatty acids, natural antioxidants, and fiber, modulate inflammation and, thereby, appear to be linked to increased risk of breast cancer and mortality.

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Title: Obesity, Dietary Factors, Nutrition, and Breast Cancer Risk
Authors: Annina Seiler
Michelle A. Chen
Ryan L. Brown
Christopher P. Fagundes
Publication date: 01-03-2018
Publisher: Springer US
Published in: Current Breast Cancer Reports / Issue 1/2018
Print ISSN: 1943-4588
Electronic ISSN: 1943-4596
DOI: https://doi.org/10.1007/s12609-018-0264-0

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Keynote webinar | Spotlight on antibody–drug conjugates in cancer