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Breast Cancer Research
Published in: Breast Cancer Research 1/2016

Open Access 01-12-2016 | Research article

Adolescent fiber intake and mammographic breast density in premenopausal women

Authors: Lusine Yaghjyan, Gabriela L. Ghita, Bernard Rosner, Maryam Farvid, Kimberly A. Bertrand, Rulla M. Tamimi

Published in: Breast Cancer Research | Issue 1/2016

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Abstract

Background

To date, there is limited and inconsistent epidemiologic evidence for associations of adolescent diet with mammographic breast density, a strong and consistent predictor of breast cancer. We investigated the association of adolescent fiber intake with mammographic density in premenopausal women.

Methods

This study included 743 cancer-free premenopausal women (mean age, 44.9 years) within the Nurses’ Health Study II cohort. Percent breast density, absolute dense and non-dense areas were measured from digitized film mammograms using a computer-assisted thresholding technique. Adolescent and adult diet were assessed with a food frequency questionnaire; energy-adjusted nutrient intakes were estimated for each food item. Information regarding breast cancer risk factors was obtained from baseline or biennial questionnaires closest to the mammogram date. We used generalized linear regression to quantify associations between quartiles of adolescent fiber intake and each of the breast density measures, adjusted for potential confounders. Associations were examined separately for total fiber intake; fiber from fruits, vegetables, legumes, and cereal; and food sources of fiber (fruits, vegetables, and nuts).

Results

In multivariable analyses, total fiber intake during adolescence was not associated with percent breast density (p for trend = 0.64), absolute dense area (p for trend = 0.80), or non-dense area (p for trend = 0.75). Similarly, neither consumption of fiber from fruits, vegetables, legumes, or cereal nor specific sources of fiber intake (fruits, vegetables, or nuts) during adolescence were associated with any of the mammographic density phenotypes.

Conclusions

Our findings do not support the hypothesis that adolescent fiber intake is associated with premenopausal mammographic breast density.
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Metadata
Title
Adolescent fiber intake and mammographic breast density in premenopausal women
Authors
Lusine Yaghjyan
Gabriela L. Ghita
Bernard Rosner
Maryam Farvid
Kimberly A. Bertrand
Rulla M. Tamimi
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 1/2016
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/s13058-016-0747-8

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