Skip to main content
Top
Published in: The journal of nutrition, health & aging 5/2020

01-05-2020 | SARS-CoV-2

The New Challenge of Geriatrics: Saving Frail Older People from the SARS-COV-2 Pandemic Infection,

Authors: Francesco Landi, C. Barillaro, A. Bellieni, V. Brandi, A. Carfì, M. D’Angelo, D. Fusco, G. Landi, R. Lo Monaco, A. M. Martone, E. Marzetti, F. Pagano, C. Pais, A. Russo, S. Salini, M. Tosato, A. Tummolo, F. Benvenuto, G. Bramato, L. Catalano, F. Ciciarello, I. Martis, S. Rocchi, E. Rota, A. Salerno, M. Tritto, A. Sgadari, G. Zuccalà, R. Bernabei, Gemelli Against COVID-19 Geriatric Team

Published in: The journal of nutrition, health & aging | Issue 5/2020

Login to get access

Excerpt

In December 2019, a relevant number of patients affected by a mysterious pneumonia has been documented in Wuhan, China (1). Around the end of last year, the causative agent of this unexplained pneumonia has been identified as a new coronavirus. This virus has been “baptized” as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the relative disease has been called as coronavirus disease 2019 (COVID-19) by the World Health Organization. The COVID-19 epidemic is spreading in China and all over the world now as pandemic infection (1). …
Literature
2.
go back to reference Xu J, Zhao S, Teng T, Abdalla AE, Zhu W, Xie L, Wang Y, Guo X. Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARSCoV- 2and SARS-CoV. Viruses. 2020 Feb 22;12(2). pii: E244. doi: https://doi.org/10.3390/v12020244. Xu J, Zhao S, Teng T, Abdalla AE, Zhu W, Xie L, Wang Y, Guo X. Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARSCoV- 2and SARS-CoV. Viruses. 2020 Feb 22;12(2). pii: E244. doi: https://​doi.​org/​10.​3390/​v12020244.
3.
go back to reference Wang C, Horby PW, Hayden FG, Gao GF. A novel coronavirus outbreak of global health concern. Lancet 2020 Feb 15;395(10223):470–473.CrossRef Wang C, Horby PW, Hayden FG, Gao GF. A novel coronavirus outbreak of global health concern. Lancet 2020 Feb 15;395(10223):470–473.CrossRef
4.
go back to reference Xu H, Zhong L, Deng J, Peng J, Dan H, Zeng X, Li T, Chen Q. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci. 2020 Feb 24;12(1):8.CrossRef Xu H, Zhong L, Deng J, Peng J, Dan H, Zeng X, Li T, Chen Q. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci. 2020 Feb 24;12(1):8.CrossRef
5.
go back to reference Guo YR, Cao QD, Hong ZS, Tan YY, Chen SD, Jin HJ, Tan KS, Wang DY, Yan Y. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak — an update on the status. Mil Med Res 2020 Mar 13;7(1):11.CrossRef Guo YR, Cao QD, Hong ZS, Tan YY, Chen SD, Jin HJ, Tan KS, Wang DY, Yan Y. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak — an update on the status. Mil Med Res 2020 Mar 13;7(1):11.CrossRef
6.
go back to reference Ou X, Liu Y, Lei X, Li P, Mi D, Ren L, Guo L, Guo R, Chen T, Hu J, Xiang Z, Mu Z, Chen X, Chen J, Hu K, Jin Q, Wang J, Qian Z. Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV. Nat Commun 2020 Mar 27;11(1):1620.CrossRef Ou X, Liu Y, Lei X, Li P, Mi D, Ren L, Guo L, Guo R, Chen T, Hu J, Xiang Z, Mu Z, Chen X, Chen J, Hu K, Jin Q, Wang J, Qian Z. Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV. Nat Commun 2020 Mar 27;11(1):1620.CrossRef
7.
go back to reference Prem K, Liu Y, Russell TW, Kucharski AJ, Eggo RM, Davies N. The effect of control strategies to reduce social mixing on outcomes of the COVID-19 epidemic in Wuhan, China: a modelling study. Lancet Public Health 2020 Mar 25. pii: S2468-2667(20)30073-6. Prem K, Liu Y, Russell TW, Kucharski AJ, Eggo RM, Davies N. The effect of control strategies to reduce social mixing on outcomes of the COVID-19 epidemic in Wuhan, China: a modelling study. Lancet Public Health 2020 Mar 25. pii: S2468-2667(20)30073-6.
9.
go back to reference Zhang L, Ma L, Sun F, Tang Z, Chan P. A Multicenter Study of Multimorbidity in Older Adult Inpatients in China. J Nutr Health Aging 2020;24(3):269–276.CrossRef Zhang L, Ma L, Sun F, Tang Z, Chan P. A Multicenter Study of Multimorbidity in Older Adult Inpatients in China. J Nutr Health Aging 2020;24(3):269–276.CrossRef
11.
go back to reference Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA 2020 Feb 24. doi: https://doi.org/10.1001/jama.2020.2648. Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA 2020 Feb 24. doi: https://​doi.​org/​10.​1001/​jama.​2020.​2648.
12.
go back to reference Li Q, Guan X, Wu P, et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. N Engl J Med 2020;382(13):1199–1207.CrossRef Li Q, Guan X, Wu P, et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. N Engl J Med 2020;382(13):1199–1207.CrossRef
13.
go back to reference Zou L, Ruan F, Huang M, et al. SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients. N Engl J Med 2020;382(12):1177–1179.CrossRef Zou L, Ruan F, Huang M, et al. SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients. N Engl J Med 2020;382(12):1177–1179.CrossRef
15.
go back to reference Yang W, Cao Q, Qin L et al. Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19):A multi-center study in Wenzhou city, Zhejiang, China. J Infect 2020;80(4):388–393.CrossRef Yang W, Cao Q, Qin L et al. Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19):A multi-center study in Wenzhou city, Zhejiang, China. J Infect 2020;80(4):388–393.CrossRef
17.
go back to reference Wilder-Smith A, Freedman DO. Isolation, quarantine, social distancing and community containment: pivotal role for old-style public health measures in the novel coronavirus (2019-nCoV) outbreak. J Travel Med 2020;27(2). pii: taaa020. doi: https://doi.org/10.1093/jtm/taaa020. Wilder-Smith A, Freedman DO. Isolation, quarantine, social distancing and community containment: pivotal role for old-style public health measures in the novel coronavirus (2019-nCoV) outbreak. J Travel Med 2020;27(2). pii: taaa020. doi: https://​doi.​org/​10.​1093/​jtm/​taaa020.
19.
go back to reference Chan JF, Yuan 2, Kok KH et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 2020;395(10223):514–523.CrossRef Chan JF, Yuan 2, Kok KH et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 2020;395(10223):514–523.CrossRef
22.
go back to reference Holshue ML, DeBolt C, Lindquist S et al. First Case of 2019 Novel Coronavirus in the United States. N Engl J Med 2020;382(10):929–936.CrossRef Holshue ML, DeBolt C, Lindquist S et al. First Case of 2019 Novel Coronavirus in the United States. N Engl J Med 2020;382(10):929–936.CrossRef
23.
go back to reference Gao J, Tian Z, Yang X. Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies. Biosci Trends 2020 Mar 16;14(1):72–73.CrossRef Gao J, Tian Z, Yang X. Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies. Biosci Trends 2020 Mar 16;14(1):72–73.CrossRef
24.
go back to reference Yan Y, Zou Z, Sun Y et al. Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model. Cell Res 2013;23(2):300–2.CrossRef Yan Y, Zou Z, Sun Y et al. Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model. Cell Res 2013;23(2):300–2.CrossRef
28.
go back to reference Morales-Martínez F. Editorial: A Teaching Geriatric Hospital. J Nutr Health Aging 2019;23(1):4–8.CrossRef Morales-Martínez F. Editorial: A Teaching Geriatric Hospital. J Nutr Health Aging 2019;23(1):4–8.CrossRef
29.
go back to reference Pitkälä KH, Martin FC, Maggi S, Jyväkorpi SK, Strandberg TE. Status of Geriatrics in 22 Countries. J Nutr Health Aging 2018;22(5):627–631.CrossRef Pitkälä KH, Martin FC, Maggi S, Jyväkorpi SK, Strandberg TE. Status of Geriatrics in 22 Countries. J Nutr Health Aging 2018;22(5):627–631.CrossRef
30.
go back to reference Sánchez A, Villalba-Mora E, Peinado IS, Rodriguez-Maña L. Integrated Care Program for Older Adults: Analysis and Improvement. J Nutr Health Aging 2017;21(8):867–873.CrossRef Sánchez A, Villalba-Mora E, Peinado IS, Rodriguez-Maña L. Integrated Care Program for Older Adults: Analysis and Improvement. J Nutr Health Aging 2017;21(8):867–873.CrossRef
31.
go back to reference Heymann DL, Shindo N. COVID-19: what is next for public health? Lancet. 2020 Feb 22;395(10224):542–545.CrossRef Heymann DL, Shindo N. COVID-19: what is next for public health? Lancet. 2020 Feb 22;395(10224):542–545.CrossRef
32.
go back to reference Thompson R. Pandemic potential of 2019-nCoV. Lancet Infect Dis. 2020 Mar;20(3):280.CrossRef Thompson R. Pandemic potential of 2019-nCoV. Lancet Infect Dis. 2020 Mar;20(3):280.CrossRef
Metadata
Title
The New Challenge of Geriatrics: Saving Frail Older People from the SARS-COV-2 Pandemic Infection,
Authors
Francesco Landi
C. Barillaro
A. Bellieni
V. Brandi
A. Carfì
M. D’Angelo
D. Fusco
G. Landi
R. Lo Monaco
A. M. Martone
E. Marzetti
F. Pagano
C. Pais
A. Russo
S. Salini
M. Tosato
A. Tummolo
F. Benvenuto
G. Bramato
L. Catalano
F. Ciciarello
I. Martis
S. Rocchi
E. Rota
A. Salerno
M. Tritto
A. Sgadari
G. Zuccalà
R. Bernabei
Gemelli Against COVID-19 Geriatric Team
Publication date
01-05-2020
Publisher
Springer Paris
Published in
The journal of nutrition, health & aging / Issue 5/2020
Print ISSN: 1279-7707
Electronic ISSN: 1760-4788
DOI
https://doi.org/10.1007/s12603-020-1356-x

Other articles of this Issue 5/2020

The journal of nutrition, health & aging 5/2020 Go to the issue