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The journal of nutrition, health & aging

Published in:

01-03-2020

Associations of TNF-Α −308 G>A and TNF-Β 252 A>G with Physical Function and BNP—Rugao Longevity and Ageing Study

Authors: S. Yao, Y. S. Zhu, G. P. Shi, J. H. Guo, Z. D. Wang, X. F. Chu, X. Y. Jiang, Li Jin, Xiao-Feng Wang

Published in: The journal of nutrition, health & aging | Issue 3/2020

Abstract

Objectives

To explore the associations of TNF-α −308 G>A (rs1800629) and TNF-β 252 A>G (rs909253) with physical function and plasma B-type natriuretic peptide (BNP).

Methods

Data of 1747 community-dwelling elders from the ageing arm of the Rugao Longevity and Ageing Study was used. Physical function was measured by handgrip strength, Timed Up and Go (TUG) test and 5-meter walking test (5MWT).

Results

AA genotype of the TNF-α −308 G>A was associated with higher mean time of TUG test and 5MWT (multivariable adjusted β=5.75 and 5.70, respectively, p<0.05), compared with GG genotype. For the TNF-β 252 A>G polymorphism, GG genotype was associated with higher mean time of TUG test and 5MWT (multivariable adjusted β=1.55 and 0.83, respectively, p<0.05) and lower handgrip strength (multivariable adjusted β=−0.69, p<0.05), compared with AA genotype. Further, GG was associated with greater odds of low handgrip strength (OR=1.47, 95% CI=1.06–2.04), low speed of TUG test (OR=1.87, 95% CI=1.20–2.01) and elevated BNP (OR=1.30, 95% CI=1.08–1.84). GG also interacted with elevated BNP to be associated with greater odds of low handgrip strength and 5MWT.

Conclusions

TNF-β 252 A>G was associated with physical function measurements, plasma BNP level, and odds of elevated BNP in an elderly population. TNF-β 252 A>G also interacted with elevated BNP to be associated with greater odds of physical function measurements.

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Title: Associations of TNF-Α −308 G>A and TNF-Β 252 A>G with Physical Function and BNP—Rugao Longevity and Ageing Study
Authors: S. Yao
Y. S. Zhu
G. P. Shi
J. H. Guo
Z. D. Wang
X. F. Chu
X. Y. Jiang
Li Jin
Xiao-Feng Wang
Publication date: 01-03-2020
Publisher: Springer Paris
Published in: The journal of nutrition, health & aging / Issue 3/2020
Print ISSN: 1279-7707
Electronic ISSN: 1760-4788
DOI: https://doi.org/10.1007/s12603-020-1336-1

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Associations of TNF-Α −308 G>A and TNF-Β 252 A>G with Physical Function and BNP—Rugao Longevity and Ageing Study

Abstract

Objectives

Methods

Results

Conclusions

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Abstract

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