Skip to main content
Top
Published in: Current Cardiovascular Imaging Reports 1/2018

Open Access 01-01-2018 | Cardiac Magnetic Resonance (E Nagel and V Puntmann, Section Editors)

Characterizing Cardiac Involvement in Chronic Kidney Disease Using CMR—a Systematic Review

Authors: Kenneth Mangion, Kirsty McDowell, Patrick B. Mark, Elaine Rutherford

Published in: Current Cardiovascular Imaging Reports | Issue 1/2018

Login to get access

Abstract

Purpose of Review

The aim of the review was to identify and describe recent advances (over the last 3 years) in cardiac magnetic resonance (CMR) imaging in patients with chronic kidney disease (CKD). We conducted a literature review in line with current guidelines.

Recent Findings

The authors identified 22 studies. Patients with CKD had left ventricular global and regional dysfunction and adverse remodeling. Stress testing with CMR revealed a reduced stress-response in CKD patients. Native T1 relaxation times (as a surrogate markers of fibrosis) are elevated in CKD patients, proportional to disease duration. Patients with CKD have reduced strain magnitudes and reduced aortic distensibility.

Summary

CMR has diagnostic utility to identify and characterize cardiac involvement in this patient group. A number of papers have described novel findings over the last 3 years, suggesting that CMR has potential to become more widely used in studies in this patient group.
Literature
3.
go back to reference GBD 2013 Mortality and causes of death collaborators. Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet. 2015;385(9963):117–71. GBD 2013 Mortality and causes of death collaborators. Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet. 2015;385(9963):117–71.
5.
go back to reference U.S. Renal Data System. USRDS [Internet]. USRDS 2007 Annual Data Report: Atlas of End-Stage Renal Disease in the United States, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 2007. Available from: https://www.usrds.org/atlas07.aspx. U.S. Renal Data System. USRDS [Internet]. USRDS 2007 Annual Data Report: Atlas of End-Stage Renal Disease in the United States, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 2007. Available from: https://​www.​usrds.​org/​atlas07.​aspx.
6.
go back to reference Chronic Kidney Disease Prognosis Consortium, Matsushita K, van der Velde M, Astor BC, Woodward M, Levey AS, et al. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. Lancet Lond Engl. 2010;375(9731):2073–81.CrossRef Chronic Kidney Disease Prognosis Consortium, Matsushita K, van der Velde M, Astor BC, Woodward M, Levey AS, et al. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. Lancet Lond Engl. 2010;375(9731):2073–81.CrossRef
9.
go back to reference Bellenger NG, Burgess MI, Ray SG, Lahiri A, Coats AJ, Cleland JG, et al. Comparison of left ventricular ejection fraction and volumes in heart failure by echocardiography, radionuclide ventriculography and cardiovascular magnetic resonance; are they interchangeable? Eur Heart J. 2000;21(16):1387–96. https://doi.org/10.1053/euhj.2000.2011. Bellenger NG, Burgess MI, Ray SG, Lahiri A, Coats AJ, Cleland JG, et al. Comparison of left ventricular ejection fraction and volumes in heart failure by echocardiography, radionuclide ventriculography and cardiovascular magnetic resonance; are they interchangeable? Eur Heart J. 2000;21(16):1387–96. https://​doi.​org/​10.​1053/​euhj.​2000.​2011.
10.
go back to reference Grothues F, Smith GC, Moon JCC, Bellenger NG, Collins P, Klein HU, et al. Comparison of interstudy reproducibility of cardiovascular magnetic resonance with two-dimensional echocardiography in normal subjects and in patients with heart failure or left ventricular hypertrophy. Am J Cardiol. 2002;90(1):29–34. https://doi.org/10.1016/S0002-9149(02)02381-0. Grothues F, Smith GC, Moon JCC, Bellenger NG, Collins P, Klein HU, et al. Comparison of interstudy reproducibility of cardiovascular magnetic resonance with two-dimensional echocardiography in normal subjects and in patients with heart failure or left ventricular hypertrophy. Am J Cardiol. 2002;90(1):29–34. https://​doi.​org/​10.​1016/​S0002-9149(02)02381-0.
15.
go back to reference Arnold R, Schwendinger D, Jung S, Pohl M, Jung B, Geiger J, et al. Left ventricular mass and systolic function in children with chronic kidney disease-comparing echocardiography with cardiac magnetic resonance imaging. Pediatr Nephrol Berl Ger. 2016;31(2):255–65. https://doi.org/10.1007/s00467-015-3198-z. Arnold R, Schwendinger D, Jung S, Pohl M, Jung B, Geiger J, et al. Left ventricular mass and systolic function in children with chronic kidney disease-comparing echocardiography with cardiac magnetic resonance imaging. Pediatr Nephrol Berl Ger. 2016;31(2):255–65. https://​doi.​org/​10.​1007/​s00467-015-3198-z.
16.
go back to reference •• Buchanan C, Mohammed A, Cox E, Köhler K, Canaud B, Taal MW, et al. Intradialytic cardiac magnetic resonance imaging to assess cardiovascular responses in a short-term trial of hemodiafiltration and hemodialysis. J Am Soc Nephrol. 2016;ASN.2016060686. Technically and logistically complex study investigating the intra-dialytic myocardial hemodynamic and biomechanical changes. Novel findings . •• Buchanan C, Mohammed A, Cox E, Köhler K, Canaud B, Taal MW, et al. Intradialytic cardiac magnetic resonance imaging to assess cardiovascular responses in a short-term trial of hemodiafiltration and hemodialysis. J Am Soc Nephrol. 2016;ASN.2016060686. Technically and logistically complex study investigating the intra-dialytic myocardial hemodynamic and biomechanical changes. Novel findings .
17.
go back to reference Dundon BK, Torpey DK, Nelson AJ, Wong DTL, Duncan RF, Meredith IT, et al. Beneficial cardiovascular remodeling following arterio-venous fistula ligation post-renal transplantation: a longitudinal magnetic resonance imaging study. Clin Transpl. 2014;28(8):916–25. https://doi.org/10.1111/ctr.12402. Dundon BK, Torpey DK, Nelson AJ, Wong DTL, Duncan RF, Meredith IT, et al. Beneficial cardiovascular remodeling following arterio-venous fistula ligation post-renal transplantation: a longitudinal magnetic resonance imaging study. Clin Transpl. 2014;28(8):916–25. https://​doi.​org/​10.​1111/​ctr.​12402.
19.
go back to reference • Odudu A, Eldehni MT, McCann GP, CW MI. Randomized controlled trial of individualized dialysate cooling for cardiac protection in hemodialysis patients. Clin J Am Soc Nephrol CJASN. 2015;10(8):1408–17. Randomised control trial of CKD patients allocated to usual hemodialysis care versus cooled dialysis. Patients undergoing cooler HD experienced a regression in LV mass and had improved aortic distensibility. CrossRefPubMed • Odudu A, Eldehni MT, McCann GP, CW MI. Randomized controlled trial of individualized dialysate cooling for cardiac protection in hemodialysis patients. Clin J Am Soc Nephrol CJASN. 2015;10(8):1408–17. Randomised control trial of CKD patients allocated to usual hemodialysis care versus cooled dialysis. Patients undergoing cooler HD experienced a regression in LV mass and had improved aortic distensibility. CrossRefPubMed
26.
go back to reference Parnham S, Gleadle JM, Leong D, Grover S, Bradbrook C, Woodman RJ, et al. Myocardial perfusion is impaired in asymptomatic renal and liver transplant recipients: a cardiovascular magnetic resonance study. J Cardiovasc Magn Reson. 2015;17(1):56. https://doi.org/10.1186/s12968-015-0166-5. Parnham S, Gleadle JM, Leong D, Grover S, Bradbrook C, Woodman RJ, et al. Myocardial perfusion is impaired in asymptomatic renal and liver transplant recipients: a cardiovascular magnetic resonance study. J Cardiovasc Magn Reson. 2015;17(1):56. https://​doi.​org/​10.​1186/​s12968-015-0166-5.
28.
29.
go back to reference • Edwards NC, Moody WE, Yuan M, Hayer MK, Ferro CJ, Townend JN, et al. Diffuse interstitial fibrosis and myocardial dysfunction in early chronic kidney disease. Am J Cardiol. 2015;115(9):1311–7. Advanced CMR imaging can identify changes in myocardial tissue in the earliest stages of chronic kidney disease. CrossRefPubMed • Edwards NC, Moody WE, Yuan M, Hayer MK, Ferro CJ, Townend JN, et al. Diffuse interstitial fibrosis and myocardial dysfunction in early chronic kidney disease. Am J Cardiol. 2015;115(9):1311–7. Advanced CMR imaging can identify changes in myocardial tissue in the earliest stages of chronic kidney disease. CrossRefPubMed
30.
go back to reference Gimpel C, Jung BA, Jung S, Brado J, Schwendinger D, Burkhardt B, et al. Magnetic resonance tissue phase mapping demonstrates altered left ventricular diastolic function in children with chronic kidney disease. Pediatr Radiol. 2017;47(2):169–77. https://doi.org/10.1007/s00247-016-3741-5. Gimpel C, Jung BA, Jung S, Brado J, Schwendinger D, Burkhardt B, et al. Magnetic resonance tissue phase mapping demonstrates altered left ventricular diastolic function in children with chronic kidney disease. Pediatr Radiol. 2017;47(2):169–77. https://​doi.​org/​10.​1007/​s00247-016-3741-5.
31.
go back to reference • Graham-Brown MP, March DS, Churchward DR, Stensel DJ, Singh A, Arnold R, et al. Novel cardiac nuclear magnetic resonance method for noninvasive assessment of myocardial fibrosis in hemodialysis patients. Kidney Int. 2016;90(4):835–44. Advanced CMR imaging identifies myocardial tissue changes in chronic kidney disease patients with a longer mean hemodialysis vintage (21 months), compared with healthy volunteers. CrossRefPubMed • Graham-Brown MP, March DS, Churchward DR, Stensel DJ, Singh A, Arnold R, et al. Novel cardiac nuclear magnetic resonance method for noninvasive assessment of myocardial fibrosis in hemodialysis patients. Kidney Int. 2016;90(4):835–44. Advanced CMR imaging identifies myocardial tissue changes in chronic kidney disease patients with a longer mean hemodialysis vintage (21 months), compared with healthy volunteers. CrossRefPubMed
32.
34.
go back to reference • Rutherford E, Talle MA, Mangion K, Bell E, Rauhalammi SM, Roditi G, et al. Defining myocardial tissue abnormalities in end-stage renal failure with cardiac magnetic resonance imaging using native T1 mapping. Kidney Int [Internet]. [cited 2016 Sep 12]; Available from: http://www.sciencedirect.com/science/article/pii/S0085253816302988. Advanced CMR imaging identifies myocardial tissue changes in chronic kidney disease patients with a mean hemodialysis vintage of 6 months, compared with healthy volunteers. • Rutherford E, Talle MA, Mangion K, Bell E, Rauhalammi SM, Roditi G, et al. Defining myocardial tissue abnormalities in end-stage renal failure with cardiac magnetic resonance imaging using native T1 mapping. Kidney Int [Internet]. [cited 2016 Sep 12]; Available from: http://​www.​sciencedirect.​com/​science/​article/​pii/​S008525381630298​8. Advanced CMR imaging identifies myocardial tissue changes in chronic kidney disease patients with a mean hemodialysis vintage of 6 months, compared with healthy volunteers.
35.
go back to reference Tolouian R, Mulla ZD, Diaz J, Aguila J, Ramos-Duran L. Liver and cardiac iron deposition in patients on maintenance hemodialysis by magnetic resonance imaging T2. Iran J Kidney Dis. 2016;10(2):68–74.PubMed Tolouian R, Mulla ZD, Diaz J, Aguila J, Ramos-Duran L. Liver and cardiac iron deposition in patients on maintenance hemodialysis by magnetic resonance imaging T2. Iran J Kidney Dis. 2016;10(2):68–74.PubMed
36.
go back to reference Parfrey PS, Foley RN, Harnett JD, Kent GM, Murray DC, Barre PE. Outcome and risk factors for left ventricular disorders in chronic uraemia. Nephrol Dial Transplant. 1996;11(7):1277–85.CrossRefPubMed Parfrey PS, Foley RN, Harnett JD, Kent GM, Murray DC, Barre PE. Outcome and risk factors for left ventricular disorders in chronic uraemia. Nephrol Dial Transplant. 1996;11(7):1277–85.CrossRefPubMed
39.
go back to reference Badve SV, Palmer SC, Strippoli GFM, Roberts MA, Teixeira-Pinto A, Boudville N, et al. The validity of left ventricular mass as a surrogate end point for all-cause and cardiovascular mortality outcomes in people with CKD: a systematic review and meta-analysis. Am J Kidney Dis. 2016;68(4):554–63. https://doi.org/10.1053/j.ajkd.2016.03.418. Badve SV, Palmer SC, Strippoli GFM, Roberts MA, Teixeira-Pinto A, Boudville N, et al. The validity of left ventricular mass as a surrogate end point for all-cause and cardiovascular mortality outcomes in people with CKD: a systematic review and meta-analysis. Am J Kidney Dis. 2016;68(4):554–63. https://​doi.​org/​10.​1053/​j.​ajkd.​2016.​03.​418.
40.
go back to reference Schulz-Menger J, Bluemke DA, Bremerich J, Flamm SD, Fogel MA, Friedrich MG, et al. Standardized image interpretation and post processing in cardiovascular magnetic resonance: Society for Cardiovascular Magnetic Resonance (SCMR) Board of Trustees Task Force on Standardized Post Processing. J Cardiovasc Magn Reson. 2013;15(1):35. https://doi.org/10.1186/1532-429X-15-35. Schulz-Menger J, Bluemke DA, Bremerich J, Flamm SD, Fogel MA, Friedrich MG, et al. Standardized image interpretation and post processing in cardiovascular magnetic resonance: Society for Cardiovascular Magnetic Resonance (SCMR) Board of Trustees Task Force on Standardized Post Processing. J Cardiovasc Magn Reson. 2013;15(1):35. https://​doi.​org/​10.​1186/​1532-429X-15-35.
42.
46.
go back to reference Mangion K, Corcoran D, Carrick D, Berry C. New perspectives on the role of cardiac magnetic resonance imaging to evaluate myocardial salvage and myocardial hemorrhage after acute reperfused ST-elevation myocardial infarction. Expert Rev Cardiovasc Ther. 2016:1–12. Mangion K, Corcoran D, Carrick D, Berry C. New perspectives on the role of cardiac magnetic resonance imaging to evaluate myocardial salvage and myocardial hemorrhage after acute reperfused ST-elevation myocardial infarction. Expert Rev Cardiovasc Ther. 2016:1–12.
48.
49.
go back to reference KDOQI, National Kidney Foundation. KDOQI clinical practice guidelines and clinical practice recommendations for anemia in chronic kidney disease. Am J Kidney Dis. 2006;47(5 Suppl 3):S11–145. KDOQI, National Kidney Foundation. KDOQI clinical practice guidelines and clinical practice recommendations for anemia in chronic kidney disease. Am J Kidney Dis. 2006;47(5 Suppl 3):S11–145.
54.
go back to reference Hor KN, Baumann R, Pedrizzetti G, Tonti G, Gottliebson WM, Taylor M, et al. Magnetic resonance derived myocardial strain assessment using feature tracking. J Vis Exp. 2011;48:e2356–6. Hor KN, Baumann R, Pedrizzetti G, Tonti G, Gottliebson WM, Taylor M, et al. Magnetic resonance derived myocardial strain assessment using feature tracking. J Vis Exp. 2011;48:e2356–6.
55.
go back to reference Mangion K, Gao H, McComb C, Carrick D, Clerfond G, Zhong X, et al. A novel method for estimating myocardial strain: assessment of deformation tracking against reference magnetic resonance methods in healthy volunteers. Sci Rep. 2016;6(1):38774. https://doi.org/10.1038/srep38774. Mangion K, Gao H, McComb C, Carrick D, Clerfond G, Zhong X, et al. A novel method for estimating myocardial strain: assessment of deformation tracking against reference magnetic resonance methods in healthy volunteers. Sci Rep. 2016;6(1):38774. https://​doi.​org/​10.​1038/​srep38774.
56.
go back to reference Amundsen BH, Helle-Valle T, Edvardsen T, Torp H, Crosby J, Lyseggen E, et al. Noninvasive myocardial strain measurement by speckle tracking echocardiography: validation against sonomicrometry and tagged magnetic resonance imaging. J Am Coll Cardiol. 2006;47(4):789–93. https://doi.org/10.1016/j.jacc.2005.10.040. Amundsen BH, Helle-Valle T, Edvardsen T, Torp H, Crosby J, Lyseggen E, et al. Noninvasive myocardial strain measurement by speckle tracking echocardiography: validation against sonomicrometry and tagged magnetic resonance imaging. J Am Coll Cardiol. 2006;47(4):789–93. https://​doi.​org/​10.​1016/​j.​jacc.​2005.​10.​040.
60.
go back to reference Greenwood JP, Maredia N, Younger JF, Brown JM, Nixon J, Everett CC, et al. Cardiovascular magnetic resonance and single-photon emission computed tomography for diagnosis of coronary heart disease (CE-MARC): a prospective trial. Lancet Lond Engl. 2012;379(9814):453–60. https://doi.org/10.1016/S0140-6736(11)61335-4. Greenwood JP, Maredia N, Younger JF, Brown JM, Nixon J, Everett CC, et al. Cardiovascular magnetic resonance and single-photon emission computed tomography for diagnosis of coronary heart disease (CE-MARC): a prospective trial. Lancet Lond Engl. 2012;379(9814):453–60. https://​doi.​org/​10.​1016/​S0140-6736(11)61335-4.
Metadata
Title
Characterizing Cardiac Involvement in Chronic Kidney Disease Using CMR—a Systematic Review
Authors
Kenneth Mangion
Kirsty McDowell
Patrick B. Mark
Elaine Rutherford
Publication date
01-01-2018
Publisher
Springer US
Published in
Current Cardiovascular Imaging Reports / Issue 1/2018
Print ISSN: 1941-9066
Electronic ISSN: 1941-9074
DOI
https://doi.org/10.1007/s12410-018-9441-9