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Published in: Current Cardiovascular Imaging Reports 5/2015

01-05-2015 | Intravascular Imaging (I.-K. Jang, Section Editor)

An Integrated Backscatter Ultrasound Technique for Coronary Plaque Imaging

Author: Masanori Kawasaki

Published in: Current Cardiovascular Imaging Reports | Issue 5/2015

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Abstract

The instability of atherosclerotic coronary plaques is related to their histological composition and the thickness of their fibrous caps. Therefore, recognition of the tissue characteristics of coronary plaques is important to understand and prevent coronary artery disease. Recently, an ultrasound integrated backscatter (IB) technique has been developed. Ultrasound signals have unique characteristics of reflection. That is, the ultrasound IB power ratio is a function of the difference in acoustic characteristic impedance between the medium and target tissue, and the acoustic characteristic impedance is determined by the density of tissue multiplied by the speed of sound. This principle allows for tissue characterization of coronary plaques for the risk stratification in patients with coronary artery disease. Two- and three-dimensional IB color-coded maps for the evaluation of tissue components can be constructed to detect four major components: fibrous, dense fibrosis, lipid pool, and calcification. Many studies have shown the reliability and usefulness of the IB technique.
Literature
1.
go back to reference Virmani R, Kolodgie FD, Burke AP, et al. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20:1262–75.CrossRefPubMed Virmani R, Kolodgie FD, Burke AP, et al. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20:1262–75.CrossRefPubMed
2.
go back to reference Gronholdt ML, Nordestgaard BG, Schroeder TV, et al. Ultrasonic echolucent carotid plaques predict future strokes. Circulation. 2001;104:68–73.CrossRefPubMed Gronholdt ML, Nordestgaard BG, Schroeder TV, et al. Ultrasonic echolucent carotid plaques predict future strokes. Circulation. 2001;104:68–73.CrossRefPubMed
4.
go back to reference Horie T, Sekiguchi M, Hirosawa K. Coronary thrombosis in pathogenesis of acute myocardial infarction. Histopathological study of coronary arteries in 108 necropsied cases using serial section. Br Heart J. 1978;40:153–61.CrossRefPubMedCentralPubMed Horie T, Sekiguchi M, Hirosawa K. Coronary thrombosis in pathogenesis of acute myocardial infarction. Histopathological study of coronary arteries in 108 necropsied cases using serial section. Br Heart J. 1978;40:153–61.CrossRefPubMedCentralPubMed
5.
go back to reference Mizuno K, Satomura K, Miyamoto A, et al. Angioscopic evaluation of coronary artery thrombi in acute coronary syndromes. N Engl J Med. 1992;326:287–91.CrossRefPubMed Mizuno K, Satomura K, Miyamoto A, et al. Angioscopic evaluation of coronary artery thrombi in acute coronary syndromes. N Engl J Med. 1992;326:287–91.CrossRefPubMed
6.
go back to reference Kawasaki M, Takatsu H, Noda T, et al. Non-invasive tissue characterization of human atherosclerotic lesions in carotid and femoral arteries by ultrasound integrated backscatter: comparison between histology and integrated backscatter images before and after death. J Am Coll Cardiol. 2001;38:486–92.CrossRefPubMed Kawasaki M, Takatsu H, Noda T, et al. Non-invasive tissue characterization of human atherosclerotic lesions in carotid and femoral arteries by ultrasound integrated backscatter: comparison between histology and integrated backscatter images before and after death. J Am Coll Cardiol. 2001;38:486–92.CrossRefPubMed
7.
go back to reference Kawasaki M, Hattori A, Ishihara Y, et al. Tissue characterization of coronary plaques and assessment of thickness of fibrous cap using integrated backscatter intravascular ultrasound. Comparison with histology and optical coherence tomography. Circ J. 2010;74:2641–8.CrossRefPubMed Kawasaki M, Hattori A, Ishihara Y, et al. Tissue characterization of coronary plaques and assessment of thickness of fibrous cap using integrated backscatter intravascular ultrasound. Comparison with histology and optical coherence tomography. Circ J. 2010;74:2641–8.CrossRefPubMed
8.
go back to reference Okubo M, Kawasaki M, Ishihara Y, et al. Tissue characterization of coronary plaques: comparison of integrated backscatter intravascular ultrasound with virtual histology intravascular ultrasound. Circ J. 2008;72:1631–9.CrossRefPubMed Okubo M, Kawasaki M, Ishihara Y, et al. Tissue characterization of coronary plaques: comparison of integrated backscatter intravascular ultrasound with virtual histology intravascular ultrasound. Circ J. 2008;72:1631–9.CrossRefPubMed
9.
go back to reference Tearney GJ, Regar E, Akasaka T, et al. Consensus standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies: a report from the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation. International Working Group for Intravascular Optical Coherence Tomography (IWG-IVOCT). J Am Coll Cardiol. 2012;59:1058–72.CrossRefPubMed Tearney GJ, Regar E, Akasaka T, et al. Consensus standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies: a report from the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation. International Working Group for Intravascular Optical Coherence Tomography (IWG-IVOCT). J Am Coll Cardiol. 2012;59:1058–72.CrossRefPubMed
10.
go back to reference Jang IK, Tearney GJ, MacNeill B, et al. In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography. Circulation. 2005;111:1551–5.CrossRefPubMedCentralPubMed Jang IK, Tearney GJ, MacNeill B, et al. In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography. Circulation. 2005;111:1551–5.CrossRefPubMedCentralPubMed
11.
go back to reference Naghavi M, Libby P, Falk E, et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part I. Circulation. 2003;108:1664–72.CrossRefPubMed Naghavi M, Libby P, Falk E, et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part I. Circulation. 2003;108:1664–72.CrossRefPubMed
12.
go back to reference Nair A, Kuban BD, Tuzcu EM, et al. Coronary plaque classification with intravascular ultrasound radiofrequency data analysis. Circulation. 2002;106:2200–6.CrossRefPubMed Nair A, Kuban BD, Tuzcu EM, et al. Coronary plaque classification with intravascular ultrasound radiofrequency data analysis. Circulation. 2002;106:2200–6.CrossRefPubMed
13.••
go back to reference Hiro T. Three stars of the constellation of color intravascular ultrasound in the space of tissue characterization of coronary plaque. J Cardiol. 2013;61:186–7. Important review of three commercially available systems for coronary tissue characterization.CrossRefPubMed Hiro T. Three stars of the constellation of color intravascular ultrasound in the space of tissue characterization of coronary plaque. J Cardiol. 2013;61:186–7. Important review of three commercially available systems for coronary tissue characterization.CrossRefPubMed
14.
go back to reference Sano K, Kawasaki M, Ishihara Y, et al. Assessment of vulnerable plaques causing acute coronary syndrome using integrated backscatter intravascular ultrasound. J Am Coll Cardiol. 2006;47:734–41.CrossRefPubMed Sano K, Kawasaki M, Ishihara Y, et al. Assessment of vulnerable plaques causing acute coronary syndrome using integrated backscatter intravascular ultrasound. J Am Coll Cardiol. 2006;47:734–41.CrossRefPubMed
15.
go back to reference Amano T, Matsubara T, Uetani T, et al. Lipid-rich plaques predict non-target-lesion ischemic events in patients undergoing percutaneous coronary intervention. Circ J. 2011;75:157–66.CrossRefPubMed Amano T, Matsubara T, Uetani T, et al. Lipid-rich plaques predict non-target-lesion ischemic events in patients undergoing percutaneous coronary intervention. Circ J. 2011;75:157–66.CrossRefPubMed
16.
go back to reference Glagov S, Weisenberg E, Zarins CK, et al. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med. 1987;316:1371–5.CrossRefPubMed Glagov S, Weisenberg E, Zarins CK, et al. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med. 1987;316:1371–5.CrossRefPubMed
17.
go back to reference Takiuchi S, Rakugi H, Honda K, et al. Quantitative ultrasonic tissue characterization can identify high-risk atherosclerotic alteration in human carotid arteries. Circulation. 2000;102:766–70.CrossRefPubMed Takiuchi S, Rakugi H, Honda K, et al. Quantitative ultrasonic tissue characterization can identify high-risk atherosclerotic alteration in human carotid arteries. Circulation. 2000;102:766–70.CrossRefPubMed
18.
go back to reference Uetani T, Amano T, Ando H, et al. The correlation between lipid volume in the target lesion, measured by integrated backscatter intravascular ultrasound, and post-procedural myocardial infarction in patients with elective stent implantation. Eur Heart J. 2008;29:1714–20.CrossRefPubMed Uetani T, Amano T, Ando H, et al. The correlation between lipid volume in the target lesion, measured by integrated backscatter intravascular ultrasound, and post-procedural myocardial infarction in patients with elective stent implantation. Eur Heart J. 2008;29:1714–20.CrossRefPubMed
19.
go back to reference Taylor AJ, Kent SM, Flaherty PJ, et al. ARBITER: arterial biology for the investigation of the treatment effects of reducing cholesterol. A randomized trial comparing the effects of atorvastatin and pravastatin on carotid intima medial thickness. Circulation. 2002;106:2055–60.CrossRefPubMed Taylor AJ, Kent SM, Flaherty PJ, et al. ARBITER: arterial biology for the investigation of the treatment effects of reducing cholesterol. A randomized trial comparing the effects of atorvastatin and pravastatin on carotid intima medial thickness. Circulation. 2002;106:2055–60.CrossRefPubMed
20.
go back to reference Long-Term Investigation with Pravastatin in Ischemic Disease (LIPID) Study Group: Prevention of cardiovascular events and death with pravastatin in patient with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med. 1998;339:1349–57. Long-Term Investigation with Pravastatin in Ischemic Disease (LIPID) Study Group: Prevention of cardiovascular events and death with pravastatin in patient with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med. 1998;339:1349–57.
21.
go back to reference Kawasaki M, Sano K, Okubo M, et al. Volumetric quantitative analysis of tissue characteristics of coronary plaques after statin therapy using three dimensional integrated backscatter intravascular ultrasound. J Am Coll Cardiol. 2005;45:1946–53.CrossRefPubMed Kawasaki M, Sano K, Okubo M, et al. Volumetric quantitative analysis of tissue characteristics of coronary plaques after statin therapy using three dimensional integrated backscatter intravascular ultrasound. J Am Coll Cardiol. 2005;45:1946–53.CrossRefPubMed
22.
go back to reference Otagiri K, Tsutsui H, Kumazaki S, et al. Early intervention with rosuvastatin decreases the lipid components of the plaque in acute coronary syndrome: analysis using integrated backscatter IVUS (ELAN study). Circ J. 2011;75:633–41.CrossRefPubMed Otagiri K, Tsutsui H, Kumazaki S, et al. Early intervention with rosuvastatin decreases the lipid components of the plaque in acute coronary syndrome: analysis using integrated backscatter IVUS (ELAN study). Circ J. 2011;75:633–41.CrossRefPubMed
23.
go back to reference Kawasaki M. An integrated backscatter ultrasound technique for the detection of coronary and carotid atherosclerotic lesions. Sensors. 2015;15:979–94.CrossRefPubMedCentralPubMed Kawasaki M. An integrated backscatter ultrasound technique for the detection of coronary and carotid atherosclerotic lesions. Sensors. 2015;15:979–94.CrossRefPubMedCentralPubMed
24.
go back to reference Sathyanarayana S, Carlier S, Li W, et al. Characterisation of atherosclerotic plaque by spectral similarity of radiofrequency intravascular ultrasound signals. EuroIntervention. 2009;5:133–9.CrossRefPubMed Sathyanarayana S, Carlier S, Li W, et al. Characterisation of atherosclerotic plaque by spectral similarity of radiofrequency intravascular ultrasound signals. EuroIntervention. 2009;5:133–9.CrossRefPubMed
25.••
go back to reference Yamada R, Okura H, Kume T, et al. A comparison between 40 MHz intravascular ultrasound iMap imaging system and integrated backscatter intravascular ultrasound. J Cardiol. 2013;61:149–54. Interesting comparison between IB-IVUS and iMAP.CrossRefPubMed Yamada R, Okura H, Kume T, et al. A comparison between 40 MHz intravascular ultrasound iMap imaging system and integrated backscatter intravascular ultrasound. J Cardiol. 2013;61:149–54. Interesting comparison between IB-IVUS and iMAP.CrossRefPubMed
26.
go back to reference Murashige A, Hiro T, Fujii T, et al. Detection of lipid-laden atherosclerotic plaque by wavelet analysis of radio-frequency intravascular ultrasound signals: in vitro validation and preliminary in vivo application. J Am Coll Cardiol. 2005;45:1954–60.CrossRefPubMed Murashige A, Hiro T, Fujii T, et al. Detection of lipid-laden atherosclerotic plaque by wavelet analysis of radio-frequency intravascular ultrasound signals: in vitro validation and preliminary in vivo application. J Am Coll Cardiol. 2005;45:1954–60.CrossRefPubMed
27.
go back to reference Daubechies I, Grossmann A. An integral transform related to quantization. J Mat Phys. 1980;21:2080–90.CrossRef Daubechies I, Grossmann A. An integral transform related to quantization. J Mat Phys. 1980;21:2080–90.CrossRef
28.
go back to reference Li X, Wu W, Chung Y, et al. Novel PMN-PT free standing film for high frequency (80 MHz) intravascular ultrasonic imaging. IEEE Trans Ultrason Ferroelectr Freq Control. 2011;58:2281–8.CrossRefPubMedCentralPubMed Li X, Wu W, Chung Y, et al. Novel PMN-PT free standing film for high frequency (80 MHz) intravascular ultrasonic imaging. IEEE Trans Ultrason Ferroelectr Freq Control. 2011;58:2281–8.CrossRefPubMedCentralPubMed
29.
go back to reference Li X, Li J, Jing J, et al. Integrated IVUS-OCT imaging for atherosclerotic plaque characterization. IEEE J Sel Top Quantum Electron. 2014;20:7100108.PubMedCentralPubMed Li X, Li J, Jing J, et al. Integrated IVUS-OCT imaging for atherosclerotic plaque characterization. IEEE J Sel Top Quantum Electron. 2014;20:7100108.PubMedCentralPubMed
30.••
go back to reference Yamaki T, Kawasaki M, Jang IK, et al. Comparison between integrated backscatter intravascular ultrasound and 64-slice multi-detector row computed tomography for tissue characterization and volumetric assessment of coronary plaques. Cardiovasc Ultrasound. 2012;10:33. Interesting comparison between IB-IVUS and multi-detector row computed tomography.CrossRefPubMedCentralPubMed Yamaki T, Kawasaki M, Jang IK, et al. Comparison between integrated backscatter intravascular ultrasound and 64-slice multi-detector row computed tomography for tissue characterization and volumetric assessment of coronary plaques. Cardiovasc Ultrasound. 2012;10:33. Interesting comparison between IB-IVUS and multi-detector row computed tomography.CrossRefPubMedCentralPubMed
31.
go back to reference Lockwood GR, Ryan LK, Hunt JW, et al. Measurement of the ultrasound properties of vascular tissue and blood from 35-65 Mhz. Ultrasound Med Biol. 1991;17:653–66.CrossRefPubMed Lockwood GR, Ryan LK, Hunt JW, et al. Measurement of the ultrasound properties of vascular tissue and blood from 35-65 Mhz. Ultrasound Med Biol. 1991;17:653–66.CrossRefPubMed
32.
go back to reference Siegel RJ, Swan K, Edwalds G, et al. Limitations of postmorterm assessment of human coronary artery size and luminal narrowing: differential effects of tissue fixation and processing on vessel with different degrees of atherosclerosis. J Am Coll Cardiol. 1985;5:342–6.CrossRefPubMed Siegel RJ, Swan K, Edwalds G, et al. Limitations of postmorterm assessment of human coronary artery size and luminal narrowing: differential effects of tissue fixation and processing on vessel with different degrees of atherosclerosis. J Am Coll Cardiol. 1985;5:342–6.CrossRefPubMed
33.
go back to reference Picano E, Landini L, Distante A, et al. Different degreed of atherosclerosis detected by backscattered ultrasound: an in vitro study on fixed human aortic walls. J Clin Ultrasound. 1983;11:375–9.CrossRefPubMed Picano E, Landini L, Distante A, et al. Different degreed of atherosclerosis detected by backscattered ultrasound: an in vitro study on fixed human aortic walls. J Clin Ultrasound. 1983;11:375–9.CrossRefPubMed
34.
go back to reference Okubo M, Kawasaki M, Ishihara Y, et al. Development of integrated backscatter intravascular ultrasound for tissue characterization of coronary plaques. Ultrasound Med Biol. 2008;34:655–63.CrossRefPubMed Okubo M, Kawasaki M, Ishihara Y, et al. Development of integrated backscatter intravascular ultrasound for tissue characterization of coronary plaques. Ultrasound Med Biol. 2008;34:655–63.CrossRefPubMed
35.
go back to reference Kume T, Okura H, Kawamoto T, et al. Assessment of the histological characteristics of coronary arterial plaque with severe calcification. Circ J. 2007;71:643–7.CrossRefPubMed Kume T, Okura H, Kawamoto T, et al. Assessment of the histological characteristics of coronary arterial plaque with severe calcification. Circ J. 2007;71:643–7.CrossRefPubMed
36.
go back to reference Picano E, Landini L, Distante A, et al. Angle dependence of ultrasonic backscatter in arterial tissues: a study in vitro. Circulation. 1985;72:572–6.CrossRefPubMed Picano E, Landini L, Distante A, et al. Angle dependence of ultrasonic backscatter in arterial tissues: a study in vitro. Circulation. 1985;72:572–6.CrossRefPubMed
37.
go back to reference Courtney BK, Robertson AL, Maehara A, et al. Effect of transducer position on backscattered intensity in coronary arteries. Ultrasound Med Biol. 2002;28:81–91.CrossRefPubMed Courtney BK, Robertson AL, Maehara A, et al. Effect of transducer position on backscattered intensity in coronary arteries. Ultrasound Med Biol. 2002;28:81–91.CrossRefPubMed
38.
go back to reference Mintz GS, Nissen SE, Anderson WD, et al. American College of Cardiology clinical expert consensus document on standards for acquisition, measurement and reporting of intravascular ultrasound studies (IVUS). A report of the American College of Cardiology task force on clinical expert consensus documents developed in collaboration with the European Society of Cardiology endorsed by the Society of Cardiac Angiography and Interventions. J Am Coll Cardiol. 2001;37:1478–92.CrossRefPubMed Mintz GS, Nissen SE, Anderson WD, et al. American College of Cardiology clinical expert consensus document on standards for acquisition, measurement and reporting of intravascular ultrasound studies (IVUS). A report of the American College of Cardiology task force on clinical expert consensus documents developed in collaboration with the European Society of Cardiology endorsed by the Society of Cardiac Angiography and Interventions. J Am Coll Cardiol. 2001;37:1478–92.CrossRefPubMed
Metadata
Title
An Integrated Backscatter Ultrasound Technique for Coronary Plaque Imaging
Author
Masanori Kawasaki
Publication date
01-05-2015
Publisher
Springer US
Published in
Current Cardiovascular Imaging Reports / Issue 5/2015
Print ISSN: 1941-9066
Electronic ISSN: 1941-9074
DOI
https://doi.org/10.1007/s12410-015-9333-1

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