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Journal of Nuclear Cardiology
Published in: Journal of Nuclear Cardiology 1/2022

01-02-2022 | ORIGINAL ARTICLE

Regadenoson versus dipyridamole: Evaluation of stress myocardial blood flow response on a CZT-SPECT camera

Authors: Quentin Brana, Frédérique Thibault, MD, Maxime Courtehoux, MD, Gilles Metrard, MD, Maria Joao Ribeiro, MD, PhD, Denis Angoulvant, MD, PhD, Matthieu Bailly, MD

Published in: Journal of Nuclear Cardiology | Issue 1/2022

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Abstract

Background

Regadenoson is a selective adenosine receptor agonist. It is currently unclear if the level of hyperemia differs between stress agents. We compared Myocardial Blood Flow (MBF) and Myocardial Flow Reserve (MFR) response on CZT-SPECT Myocardial Perfusion Imaging (MPI) to evaluate if dipyridamole and regadenoson could induce the same level of hyperemia.

Methods

228 patients with dynamic CZT-SPECT MPI were retrospectively analyzed (66 patients stressed with regadenoson and 162 with dipyridamole) in terms of MBF and MFR. To rule out confounding factors, two groups of 41 patients were matched for clinical characteristics in a sub-analysis, excluding high cardiovascular risk patients.

Results

Overall stress MBF was higher in regadenoson patients (1.71 ± 0.73 vs. 1.44 ± 0.55 mL·min−1·g−1 for regadenoson and dipyridamole, respectively, p < .05). However, when confounding factors were ruled out, stress MBF (1.57 ± 0.56 vs. 1.61 ± 0.62 mL·min−1·g−1 for dipyridamole and regadenoson, respectively, p = .88) and MFR (2.62 ± 0.77 vs. 2.46 ± 0.76 for dipyridamole and regadenoson, respectively, p = .40) were not different between regadenoson and dipyridamole.

Conclusions

Our results suggest that dipyridamole and regadenoson induce equivalent hyperemia in dynamic SPECT with similar stress MBF and MFR in comparable patients.
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Metadata
Title
Regadenoson versus dipyridamole: Evaluation of stress myocardial blood flow response on a CZT-SPECT camera
Authors
Quentin Brana
Frédérique Thibault, MD
Maxime Courtehoux, MD
Gilles Metrard, MD
Maria Joao Ribeiro, MD, PhD
Denis Angoulvant, MD, PhD
Matthieu Bailly, MD
Publication date
01-02-2022
Publisher
Springer International Publishing
Published in
Journal of Nuclear Cardiology / Issue 1/2022
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI
https://doi.org/10.1007/s12350-020-02271-5

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