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Published in: Journal of Nuclear Cardiology 4/2021

01-08-2021 | Systemic Lupus Erythematosus | IMAGES THAT TEACH

A positive PYP scan: Thinking beyond amyloid

Authors: Shaden Khalaf, MD, Najah Khan, MD, Mouaz Al-Mallah, MD, Mahwash Kassi, MD, Dipan Shah, MD

Published in: Journal of Nuclear Cardiology | Issue 4/2021

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Excerpt

Hydroxychloroquine (HCQ), a medication prescribed for rheumatologic disorders, has life-threatening cardiac side effects, including QT prolongation, advanced AV block, and fatal cardiomyopathies, requiring discontinuation. HCQ cardiomyopathy can result in a false positive 99mTechnetium pyrophosphate (99mTc-PYP)s scan,1,2 and is a diagnosis of exclusion. In non-ischemic cardiomyopathy (NICM) of unclear etiology, it is crucial to evaluate drug-induced cardiomyopathy. …
Literature
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go back to reference Chang ICY, Bois JP, Bois MC, Maleszewski JJ, Johnson GB, Grogan M. Hydroxychloroquine-mediated cardiotoxicity with a false-positive 99m technetium–labeled pyrophosphate scan for transthyretin-related cardiac amyloidosis. Circulation 2018;11:e007059 Chang ICY, Bois JP, Bois MC, Maleszewski JJ, Johnson GB, Grogan M. Hydroxychloroquine-mediated cardiotoxicity with a false-positive 99m technetium–labeled pyrophosphate scan for transthyretin-related cardiac amyloidosis. Circulation 2018;11:e007059
2.
go back to reference Rochlani Y, Khan MH, Behram M, Fuisz A, Cooper H, Gass A. Hydroxychloroquine (Plaquenil) cardiotoxicity: An uncommon complication of a common medication. JACC 2018;71(11 Supplement):A2395CrossRef Rochlani Y, Khan MH, Behram M, Fuisz A, Cooper H, Gass A. Hydroxychloroquine (Plaquenil) cardiotoxicity: An uncommon complication of a common medication. JACC 2018;71(11 Supplement):A2395CrossRef
Metadata
Title
A positive PYP scan: Thinking beyond amyloid
Authors
Shaden Khalaf, MD
Najah Khan, MD
Mouaz Al-Mallah, MD
Mahwash Kassi, MD
Dipan Shah, MD
Publication date
01-08-2021
Publisher
Springer International Publishing
Published in
Journal of Nuclear Cardiology / Issue 4/2021
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI
https://doi.org/10.1007/s12350-020-02149-6

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