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Journal of Nuclear Cardiology
Published in: Journal of Nuclear Cardiology 2/2019

01-04-2019 | Editorial

Landmark analysis: A primer

Author: Charity J. Morgan, PhD

Published in: Journal of Nuclear Cardiology | Issue 2/2019

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Excerpt

In the survival analysis setting, landmark analysis refers to the practice of designating a time point occurring during the follow-up period (known as the landmark time) and analyzing only those subjects who have survived until the landmark time.1 A comprehensive overview of the landmark analysis method and its use has been provided by Dafni.2 To understand why landmark analysis is sometimes necessary, consider the following hypothetical example. …
Literature
1.
Anderson JR, Cain KC, Gelber RD. Analysis of survival by tumor response. J Clin Oncol 1983;1:710-9.CrossRef
2.
Dafni U. Landmark analysis at the 25-year landmark point. Circ Cardiovasc Qual Outcomes 2011;4:363-71.CrossRefPubMed
3.
Buyse M, Piedbois P. On the relationship between response to treatment and survival time. Stat Med 1996;15:2797-812.CrossRefPubMed
4.
Gleiss A, Oberbauer R, Heinze G. An unjustified benefit: Immortal time bias in the analysis of time-dependent events. Transpl Int 2018;31:125-30.CrossRefPubMed
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Cox DR. Regression models and life-tables. J R Stat Soc Ser B 1972;34:187-220.
6.
Fisher LD, Lin DY. Time-dependent covariates in the Cox proportional-hazards regression model. Annu Rev Public Health 1999;20:145-57.CrossRefPubMed
Metadata
Title
Landmark analysis: A primer
Author
Charity J. Morgan, PhD
Publication date
01-04-2019
Publisher
Springer International Publishing
Published in
Journal of Nuclear Cardiology / Issue 2/2019
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI
https://doi.org/10.1007/s12350-019-01624-z

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