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01-12-2017 | Editorial

Optimizing quantitative myocardial perfusion by positron emission tomography for guiding CAD management

Author: K. Lance Gould, MD

Published in: Journal of Nuclear Cardiology | Issue 6/2017

Excerpt

In the current issue, Lassen et al.1 studied the effect of respiratory gating on myocardial stress perfusion imaging using positron emission tomography with Rb-82 in 48 patients randomized to adenosine or dipyridamole stress. The dipyridamole group consisted of non-smoking women without a family history of cardiovascular disease and with a mean age of 64 years. The adenosine group consisted primarily of men (86%) at a mean age of 57 years of whom 39% were current smokers and 48% had a family history of cardiovascular disease. …

Lassen ML, Rasmussen T, Christensen TE, Kjaer A, Hasbak P. Respiratory gating in cardiac PET: Effects of adenosine and dipyridamole. J Nucl Cardiol 2016.

Handel RC, et al. ACCF/ASNC/ACR/AHA/ASE/SCCT/SCMR/SNM 2009 appropriate use criteria for cardiac radionuclide imaging: a report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the American Society of Nuclear Cardiology, the American College of Radiology, the American Heart Association, the American Society of Echocardiography, the Society of Cardiovascular Computed Tomography, the Society for Cardiovascular Magnetic Resonance, and the Society of Nuclear Medicine. Circulation. 2009;119:e561–87.CrossRef

De Bruyne B, Fearon WF, Pijls NH, Barbato E, Tonino P, Piroth Z, Jagic N, Mobius-Winckler S, Rioufol G, Witt N, Kala P, MacCarthy P, Engström T, Oldroyd K, Mavromatis K, Manoharan G, Verlee P, Frobert O, Curzen N, Johnson JB, Limacher A, Nüesch E, Jüni P. FAME 2 trial investigators. Fractional flow reserve-guided PCI for stable coronary artery disease. N Engl J Med. 2014;371:1208–17.CrossRefPubMed

van Nunen LX, Zimmermann FM, Tonino PA, et al. Fractional flow reserve versus angiography for guidance of PCI in patients with multivessel coronary artery disease (FAME): 5 year follow up of a randomised controlled trial. Lancet. 2015. doi:10.1016/S01406736(15)000574.PubMed

De Bruyne B, Baudhuin T, Melin JA, Pijls NH, Sys SU, Bol A, Paulus WJ, Heyndrickx GR, Wijns W. Coronary flow reserve calculated from pressure measurements in humans. Validation with positron emission tomography. Circulation. 1994;89:1013–22.CrossRefPubMed

Loghin C, Sdringola S, Gould KL. Common artifacts in PET myocardial perfusion images due to attenuation-emission misregistration: clinical significance, causes and solutions in 1177 patients. J Nucl Med. 2004;45:1029–39.PubMed

Gould KL, Pan T, Loghin C, Johnson N, Guha A, Sdringola S. Frequent diagnostic errors in cardiac PET-CT due to misregistration of ct attenuation and emission PET images: a definitive analysis of causes, consequences and corrections. J Nucl Med. 2007;48:1112–21.CrossRefPubMed

Gould KL, Pan T, Loghin C, Johnson NP, Sdringola. Reducing radiation dose in rest stress cardiac PET-CT by single post stress cine CT for attenuation correction—quantitative validation. J Nucl Med 2008;49:738–45.

Johnson NP, Pan T, Gould KL. Shifted helical CT to optimize cardiac PET-CT co-registration: quantitative improvement and limitations. J Mol Imaging. 2010;9:256–67.

10.

Johnson NP, Gould KL. Partial volume correction incorporating Rb-82 positron range for quantitative myocardial perfusion PET based on systolic-diastolic activity ratios and phantom measurements. J Nucl Cardiol. 2011;18:247–58.CrossRefPubMed

11.

Kitkungvan D, Vejpongsa P, Korrane KP, Sdrigola SS, Gould KL. Clinical utility of enhanced relative activity recovery on systolic myocardial perfusion SPECT—lessons from PET. J Nucl Med. 2015;56:1882–8.CrossRefPubMed

12.

Bacharach SL, Carson RE. In hotblood—quantifying the arterial input function. JACC Cardiovasc Imaging. 2013;6:569–73.CrossRefPubMed

13.

Vasquez AF, Johnson NP, Gould KL. Variation in quantitative myocardial perfusion due to arterial input selection. J Am Card Cardiol CV Imaging. 2013;6:559–68.CrossRef

14.

Johnson NP, Gould KL. Regadenoson versus dipyridamole hyperemia for cardiac positron emission tomography (PET) imaging. J Am Coll Cardiol Imaging. 2015;8:438–47.CrossRef

15.

deKemp RA, Yoshinaga KY, Beanlands RSB. Will 3-dimensional PET-CT enable the routine quantification of myocardial blood flow. J Nucl Cardiol 2007;14:380–97.

16.

Renaud JM, DaSilva JN, Beanlands RSB, deKemp RA. Characterizing the normal range of myocardial blood flow with rubidium-82 and N-13 ammonia PET imaging. J. Nucl Cardiol. 2013;20:578–91.CrossRefPubMed

17.

Yoshida K, Mullani N, Gould KL. Coronary flow and flow reserve by positron emission tomography simplified for clinical application using Rb-82 or N-13 ammonia. J Nucl Med. 1996;37:1701–12.PubMed

18.

Gould KL, Johnson NP, Bateman TM, Beanlands RS, Bengel FM, Bober R, Camici PG, Cerqueira MD, Chow BJW, Di Carli MF, Dorbala S, Gewirtz H, Gropler RJ, Kaufmann PA, Knaapen P, Knuuti J, Merhige ME, Rentrop KP, Ruddy TD, Schelbert HR, Schindler TH, Schwaiger M, Sdringola S, Vitarello J, Williams KA, Gordon D, Dilsizian V, Narula J. Anatomic versus physiologic assessment of coronary artery disease: role of CFR, FFR, and PET imaging in revascularization decision-making. J Am Coll Cardiol. 2013;62:1639–53.CrossRefPubMed

19.

Gould KL, Johnson NP. Quantitative coronary physiology for clinical management: the imaging standard. Curr Cardiol Rep. 2016;18:1–10. doi:10.1007/s11886-015-0684-7.CrossRef

20.

Gould KL, Johnson NP, Kaul S, Kirkeeide RL, Mintz GS, Rentrop KP, Sdringola S, Virmani R, Narula J. Patient selection for elective revascularization to reduce myocardial infarction and mortality: new lessons from randomized trials, coronary physiology, and statistics. Circ Cardiovasc Imaging. 2015;8:e003099. doi:10.1161/CIRCIMAGING.114.003099.CrossRefPubMed

21.

Taqueti VR, Hachamovitch R, Murthy VL, Naya M, Foster CR, Hainer J, Dorbala S, Blankstein R, Di Carli MF, Global coronary flow reserve associates with adverse cardiovascular events independently of luminal angiographic severity, and modifies. The effect of early revascularization. Circulation. 2015;131:19–27.CrossRefPubMed

Title: Optimizing quantitative myocardial perfusion by positron emission tomography for guiding CAD management
Author: K. Lance Gould, MD
Publication date: 01-12-2017
Publisher: Springer US
Published in: Journal of Nuclear Cardiology / Issue 6/2017
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-016-0666-1

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