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01-10-2017 | Editorial

Microvascular function, is there a link to myocardial viability: Is this another piece to the puzzle?

Authors: Fernanda Erthal, MD, Natasha Aleksova, MD, Aun Yeong Chong, MD, Robert A. de Kemp, PhD, Rob S. B. Beanlands, MD, FRCPC

Published in: Journal of Nuclear Cardiology | Issue 5/2017

Excerpt

“It’s always the small pieces that make the big picture”—Unknown author

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Fukuoka Y., Nakano A., Tama N., et al. Impaired myocardial microcirculation in the flow-glucose metabolism mismatch regions in revascularized acute myocardial infarction. J Nucl Cardiol. 2016. doi:10.1007/s12350-016-0526-z.PubMed

Pries AR, Badimon L, Bugiardini R, et al. Coronary vascular regulation, remodelling, and collateralization: Mechanisms and clinical implications on behalf of the working group on coronary pathophysiology and microcirculation. Eur Heart J. 2015;36:3134-46. doi:10.1093/eurheartj/ehv100.CrossRefPubMed

Gould KL, Johnson NP, Bateman TM, et al. Anatomic versus physiologic assessment of coronary artery disease. Role of coronary flow reserve, fractional flow reserve, and positron emission tomography imaging in revascularization decision-making. J Am Coll Cardiol. 2013;62:1639-53. doi:10.1016/j.jacc.2013.07.076.CrossRefPubMed

Juneau D, Erthal F, Ohira H, et al. Clinical PET myocardial perfusion imaging and flow quantification. Cardiol Clin. 2016;34:69-85. doi:10.1016/j.ccl.2015.07.013.CrossRefPubMed

Ziadi MC, Dekemp RA, Williams KA, et al. Impaired myocardial flow reserve on rubidium-82 positron emission tomography imaging predicts adverse outcomes in patients assessed for myocardial ischemia. J Am Coll Cardiol. 2011;58:740-8. doi:10.1016/j.jacc.2011.01.065.CrossRefPubMed

Herzog BA, Husmann L, Valenta I, et al. Long-term prognostic value of 13N-ammonia myocardial perfusion positron emission tomography added value of coronary flow reserve. J Am Coll Cardiol. 2009;54:150-6. doi:10.1016/j.jacc.2009.02.069.CrossRefPubMed

Murthy VL, Naya M, Foster CR, et al. Improved cardiac risk assessment with noninvasive measures of coronary flow reserve. Circulation. 2011;124:2215-24. doi:10.1161/CIRCULATIONAHA.111.050427.CrossRefPubMedPubMedCentral

Pries AR, Reglin B. Coronary microcirculatory pathophysiology: Can we afford it to remain a black box? Eur Heart J. 2016;. doi:10.1093/eurheartj/ehv760.PubMedCentral

Majmudar MD, Murthy VL, Shah RV, et al. Quantification of coronary flow reserve in patients with ischaemic and non-ischaemic cardiomyopathy and its association with clinical outcomes. Eur Heart J Cardiovasc Imaging. 2015;16:900-9. doi:10.1093/ehjci/jev012.CrossRefPubMedPubMedCentral

10.

Cecchi F, Olivotto I, Gistri R, Lorenzoni R, Chiriatti G, Camici PG. Coronary microvascular dysfunction and prognosis in hypertrophic cardiomyopathy. N Engl J Med. 2003;349:1027-35. doi:10.1056/NEJMoa025050.CrossRefPubMed

11.

Neglia D, Michelassi C, Trivieri MG, et al. Prognostic role of myocardial blood flow impairment in idiopathic left ventricular dysfunction. Circulation. 2002;105:186-93.CrossRefPubMed

12.

van den Heuvel AF, van Veldhuisen DJ, van der Wall EE, et al. Regional myocardial blood flow reserve impairment and metabolic changes suggesting myocardial ischemia in patients with idiopathic dilated cardiomyopathy. J Am Coll Cardiol. 2000;35:19-28.CrossRefPubMed

13.

Fallavollita JA, Malm BJ, Canty JM. Hibernating myocardium retains metabolic and contractile reserve despite regional reductions in flow, function, and oxygen consumption at rest. Circ Res. 2003;92:48-55.CrossRefPubMed

14.

Herrero P, Markham J, Myears DW, Weinheimer CJ, Bergmann SR. Measurement of myocardial blood flow with positron emission tomography: Correction for count spillover and partial volume effects. Math Comput Model. 1988;11:807-12. doi:10.1016/0895-7177(88)90605-X.CrossRef

15.

Masci PG, Bogaert J. Post myocardial infarction of the left ventricle: The course ahead seen by cardiac MRI. Cardiovasc Diagn Ther. 2012;2:113-27. doi:10.3978/j.issn.2223-3652.2012.04.06.PubMedPubMedCentral

16.

Cuculi F, De Maria GL, Meier P, et al. Impact of microvascular obstruction on the assessment of coronary flow reserve, index of microcirculatory resistance, and fractional flow reserve after ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2014;64:1894-904. doi:10.1016/j.jacc.2014.07.987.CrossRefPubMed

17.

Beygui F, Le Feuvre C, Helft G, Maunoury C, Metzger JP. Myocardial viability, coronary flow reserve, and in-hospital predictors of late recovery of contractility following successful primary stenting for acute myocardial infarction. Heart Br Card Soc. 2003;89:179-83.CrossRef

18.

Montisci R, Chen L, Ruscazio M, et al. Non-invasive coronary flow reserve is correlated with microvascular integrity and myocardial viability after primary angioplasty in acute myocardial infarction. Heart Br Card Soc. 2006;92:1113-8. doi:10.1136/hrt.2005.078246.CrossRef

19.

Suryapranata H, Zijlstra F, MacLeod DC, van den Brand M, de Feyter PJ, Serruys PW. Predictive value of reactive hyperemic response on reperfusion on recovery of regional myocardial function after coronary angioplasty in acute myocardial infarction. Circulation. 1994;89:1109-17.CrossRefPubMed

20.

Lepper W, Hoffmann R, Kamp O, et al. Assessment of myocardial reperfusion by intravenous myocardial contrast echocardiography and coronary flow reserve after primary percutaneous transluminal coronary angioplasty [correction of angiography] in patients with acute myocardial infarction. Circulation. 2000;101:2368-74.CrossRefPubMed

21.

Ghosh N, Rimoldi OE, Beanlands RSB, Camici PG. Assessment of myocardial ischaemia and viability: Role of positron emission tomography. Eur Heart J. 2010;31:2984-95. doi:10.1093/eurheartj/ehq361.CrossRefPubMed

22.

Braunwald E, Kloner RA. The stunned myocardium: Prolonged, postischemic ventricular dysfunction. Circulation. 1982;66:1146-9. doi:10.1161/01.CIR.66.6.1146.CrossRefPubMed

23.

Ambrosio G, Betocchi S, Pace L, et al. Prolonged impairment of regional contractile function after resolution of exercise-induced angina evidence of myocardial stunning in patients with coronary artery disease. Circulation. 1996;94:2455-64. doi:10.1161/01.CIR.94.10.2455.CrossRefPubMed

24.

Barnes E, Hall RJC, Dutka DP, Camici PG. Absolute blood flow and oxygen consumption in stunned myocardium in patients with coronary artery disease. J Am Coll Cardiol. 2002;39:420-7.CrossRefPubMed

25.

Schinkel AFL, Bax JJ, Poldermans D, Elhendy A, Ferrari R, Rahimtoola SH. Hibernating myocardium: Diagnosis and patient outcomes. Curr Probl Cardiol. 2007;32:375-410. doi:10.1016/j.cpcardiol.2007.04.001.CrossRefPubMed

26.

Tillisch J, Brunken R, Marshall R, et al. Reversibility of cardiac wall-motion abnormalities predicted by positron tomography. N Engl J Med. 1986;314:884-8. doi:10.1056/NEJM198604033141405.CrossRefPubMed

27.

Beanlands RSB, Nichol G, Huszti E, et al. F-18-fluorodeoxyglucose positron emission tomography imaging-assisted management of patients with severe left ventricular dysfunction and suspected coronary disease: A randomized, controlled trial (PARR-2). J Am Coll Cardiol. 2007;50:2002-12. doi:10.1016/j.jacc.2007.09.006.CrossRefPubMed

28.

D’Egidio G, Nichol G, Williams KA, et al. Increasing benefit from revascularization is associated with increasing amounts of myocardial hibernation: A substudy of the PARR-2 trial. JACC Cardiovasc Imaging. 2009;2:1060-8. doi:10.1016/j.jcmg.2009.02.017.CrossRefPubMed

29.

Di Carli MF, Davidson M, Little R, et al. Value of metabolic imaging with positron emission tomography for evaluating prognosis in patients with coronary artery disease and left ventricular dysfunction. Am J Cardiol. 1994;73:527-33.CrossRefPubMed

30.

Allman KC, Shaw LJ, Hachamovitch R, Udelson JE. Myocardial viability testing and impact of revascularization on prognosis in patients with coronary artery disease and left ventricular dysfunction: A meta-analysis. J Am Coll Cardiol. 2002;39:1151-8.CrossRefPubMed

31.

Anselm DD, Anselm AH, Renaud J, et al. Altered myocardial glucose utilization and the reverse mismatch pattern on rubidium-82 perfusion/F-18-FDG PET during the sub-acute phase following reperfusion of acute anterior myocardial infarction. J Nucl Cardiol Off Publ Am Soc Nucl Cardiol. 2011;18:657-67. doi:10.1007/s12350-011-9389-5.CrossRef

32.

Thompson K, Saab G, Birnie D, et al. Is septal glucose metabolism altered in patients with left bundle branch block and ischemic cardiomyopathy? J Nucl Med Off Publ Soc Nucl Med. 2006;47:1763-8.

33.

Di Carli MF, Asgarzadie F, Schelbert HR, et al. Quantitative relation between myocardial viability and improvement in heart failure symptoms after revascularization in patients with ischemic cardiomyopathy. Circulation. 1995;92:3436-44.CrossRefPubMed

34.

Abraham A, Nichol G, Williams KA, et al. 18F-FDG PET imaging of myocardial viability in an experienced center with access to 18F-FDG and integration with clinical management teams: The Ottawa-FIVE substudy of the PARR 2 trial. J Nucl Med Off Publ Soc Nucl Med. 2010;51:567-74. doi:10.2967/jnumed.109.065938.

35.

Bonow RO, Maurer G, Lee KL, et al. Myocardial viability and survival in ischemic left ventricular dysfunction. N Engl J Med. 2011;364(17):1617-25. doi:10.1056/NEJMoa1100358.CrossRefPubMedPubMedCentral

36.

Mielniczuk LM, Beanlands RS. Does imaging-guided selection of patients with ischemic heart failure for high risk revascularization improve identification of those with the highest clinical benefit?: Imaging-guided selection of patients with ischemic heart failure for high-risk revascularization improves identification of those with the highest clinical benefit. Circ Cardiovasc Imaging. 2012;5:262-70. doi:10.1161/CIRCIMAGING.111.964668 discussion 270.CrossRefPubMed

37.

McArdle B, Shukla T, Bernick J, et al. Long term follow-up of outcomes with F-18-fluorodeoxyglucose positron emission tomography imaging-assisted management of patients with severe left ventricular dysfunction secondary to coronary disease. Circulation. 2014;130:A13207.

38.

Prato FS, Butler J, Sykes J, et al. Can the inflammatory response be evaluated using 18F-FDG within zones of microvascular obstruction after myocardial infarction? J Nucl Med Off Publ Soc Nucl Med. 2015;56:299-304. doi:10.2967/jnumed.114.147835.

39.

Lautamäki R, Schuleri KH, Sasano T, et al. Integration of infarct size, tissue perfusion, and metabolism by hybrid cardiac positron emission tomography/computed tomography: Evaluation in a porcine model of myocardial infarction. Circ Cardiovasc Imaging. 2009;2:299-305. doi:10.1161/CIRCIMAGING.108.846253.CrossRefPubMed

40.

Birnie D, de Kemp RA, Tang AS, et al. Reduced septal glucose metabolism predicts response to cardiac resynchronization therapy. J Nucl Cardiol Off Publ Am Soc Nucl Cardiol. 2012;19(1):73-83. doi:10.1007/s12350-011-9483-8.CrossRef

Title: Microvascular function, is there a link to myocardial viability: Is this another piece to the puzzle?
Authors: Fernanda Erthal, MD
Natasha Aleksova, MD
Aun Yeong Chong, MD
Robert A. de Kemp, PhD
Rob S. B. Beanlands, MD, FRCPC
Publication date: 01-10-2017
Publisher: Springer US
Published in: Journal of Nuclear Cardiology / Issue 5/2017
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-016-0575-3

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